Lack of Methylation in the Upstream Region of Human Papillomavirus Type 6 from Aerodigestive Tract Papillomas
(2012) In Journal of Virology 86(24). p.13790-13794- Abstract
- Methylation of the high-risk human papillomavirus type 16 (HPV16) upstream regulatory region (URR) has been described, but whether methylation is present among low-risk HPVs is unknown. The methylation status of the HPV6 URR was analyzed in papillomas from the upper aerodigestive tract of six adult patients. All CpGs in the URR were unmethylated, from both basal/intermediate and superficial cells, suggesting that methylation is not involved in the regulation of transcription from the HPV6 URR, regardless of epithelial differentiation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3379474
- author
- Ure, Agustin LU and Forslund, Ola LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Virology
- volume
- 86
- issue
- 24
- pages
- 13790 - 13794
- publisher
- American Society for Microbiology
- external identifiers
-
- wos:000311299600063
- pmid:23035223
- scopus:84870686257
- pmid:23035223
- ISSN
- 1098-5514
- DOI
- 10.1128/JVI.01938-12
- language
- English
- LU publication?
- yes
- id
- 13e2646a-2d13-4326-9f85-6c844c4da391 (old id 3379474)
- date added to LUP
- 2016-04-01 13:35:14
- date last changed
- 2022-01-27 19:58:36
@article{13e2646a-2d13-4326-9f85-6c844c4da391, abstract = {{Methylation of the high-risk human papillomavirus type 16 (HPV16) upstream regulatory region (URR) has been described, but whether methylation is present among low-risk HPVs is unknown. The methylation status of the HPV6 URR was analyzed in papillomas from the upper aerodigestive tract of six adult patients. All CpGs in the URR were unmethylated, from both basal/intermediate and superficial cells, suggesting that methylation is not involved in the regulation of transcription from the HPV6 URR, regardless of epithelial differentiation.}}, author = {{Ure, Agustin and Forslund, Ola}}, issn = {{1098-5514}}, language = {{eng}}, number = {{24}}, pages = {{13790--13794}}, publisher = {{American Society for Microbiology}}, series = {{Journal of Virology}}, title = {{Lack of Methylation in the Upstream Region of Human Papillomavirus Type 6 from Aerodigestive Tract Papillomas}}, url = {{http://dx.doi.org/10.1128/JVI.01938-12}}, doi = {{10.1128/JVI.01938-12}}, volume = {{86}}, year = {{2012}}, }