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Lack of Methylation in the Upstream Region of Human Papillomavirus Type 6 from Aerodigestive Tract Papillomas

Ure, Agustin LU and Forslund, Ola LU (2012) In Journal of Virology 86(24). p.13790-13794
Abstract
Methylation of the high-risk human papillomavirus type 16 (HPV16) upstream regulatory region (URR) has been described, but whether methylation is present among low-risk HPVs is unknown. The methylation status of the HPV6 URR was analyzed in papillomas from the upper aerodigestive tract of six adult patients. All CpGs in the URR were unmethylated, from both basal/intermediate and superficial cells, suggesting that methylation is not involved in the regulation of transcription from the HPV6 URR, regardless of epithelial differentiation.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Virology
volume
86
issue
24
pages
13790 - 13794
publisher
American Society for Microbiology
external identifiers
  • wos:000311299600063
  • pmid:23035223
  • scopus:84870686257
ISSN
1098-5514
DOI
10.1128/JVI.01938-12
language
English
LU publication?
yes
id
13e2646a-2d13-4326-9f85-6c844c4da391 (old id 3379474)
date added to LUP
2013-02-01 07:02:50
date last changed
2017-10-29 03:52:31
@article{13e2646a-2d13-4326-9f85-6c844c4da391,
  abstract     = {Methylation of the high-risk human papillomavirus type 16 (HPV16) upstream regulatory region (URR) has been described, but whether methylation is present among low-risk HPVs is unknown. The methylation status of the HPV6 URR was analyzed in papillomas from the upper aerodigestive tract of six adult patients. All CpGs in the URR were unmethylated, from both basal/intermediate and superficial cells, suggesting that methylation is not involved in the regulation of transcription from the HPV6 URR, regardless of epithelial differentiation.},
  author       = {Ure, Agustin and Forslund, Ola},
  issn         = {1098-5514},
  language     = {eng},
  number       = {24},
  pages        = {13790--13794},
  publisher    = {American Society for Microbiology},
  series       = {Journal of Virology},
  title        = {Lack of Methylation in the Upstream Region of Human Papillomavirus Type 6 from Aerodigestive Tract Papillomas},
  url          = {http://dx.doi.org/10.1128/JVI.01938-12},
  volume       = {86},
  year         = {2012},
}