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The association between radiographic severity and pre-operative function in patients undergoing primary knee replacement for osteoarthritis

Dowsey, Michelle M.; Dieppe, Paul; Lohmander, Stefan LU ; Castle, David; Liew, Danny and Choong, Peter F. M. (2012) In Knee 19(6). p.860-865
Abstract
Objective: To determine the association between radiographic osteoarthritis (OA) and pre-operative function in patients undergoing primary knee replacement. Methods: Single centre study examining pre-operative outcomes in a consecutive series of 525 patients who underwent primary knee replacement for OA between January 2006 and December 2007. Pre-operative data included: demographics, American Society of Anaesthesiologists (ASA) status and OA in the contralateral knee. The International Knee Society (IKS) rating and Short Form-12 (SF-12) were recorded for each patient. Pre-operative radiographs were read by a single observer for Kellgren and Lawrence (K&L) grading and Osteoarthritis Research Society International (OARSI) atlas... (More)
Objective: To determine the association between radiographic osteoarthritis (OA) and pre-operative function in patients undergoing primary knee replacement. Methods: Single centre study examining pre-operative outcomes in a consecutive series of 525 patients who underwent primary knee replacement for OA between January 2006 and December 2007. Pre-operative data included: demographics, American Society of Anaesthesiologists (ASA) status and OA in the contralateral knee. The International Knee Society (IKS) rating and Short Form-12 (SF-12) were recorded for each patient. Pre-operative radiographs were read by a single observer for Kellgren and Lawrence (K&L) grading and Osteoarthritis Research Society International (OARSI) atlas features. Multiple linear regression was used to assess the strength of associations between radiographic OA severity and function, adjusting for clinically relevant variables. Results: Lateral tibiofemoral osteophyte grade was an independent predictor of pre-operative function as determined by the functional sub-scale of the IKS in patients undergoing primary knee replacement (coefficient = 2.58, p = 0.033). No associations were evident between pre-operative function and modified K&L, joint space narrowing, Ahlback attrition and coronal plane deformity. Other statistically significant predictors of poorer pre-operative function included: advancing age, female gender, knee pain and poorer SF-12 mental component summary scores which including osteophyte grade accounted for 24.6% of the variation in functional scores, (r = 0.496). Conclusion: Osteophytes in the lateral compartment of the knee were associated with pre-operative function in patients with advanced knee OA. Further studies are required which examine individual radiographic features specifically in patients with advanced knee OA to determine their relationship to pre-operative pain and function. (C) 2012 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Osteoarthritis, Total knee replacement, Radiographic OA severity, Pre-operative function
in
Knee
volume
19
issue
6
pages
860 - 865
publisher
Elsevier
external identifiers
  • wos:000311329300024
  • scopus:84868212557
ISSN
1873-5800
DOI
10.1016/j.knee.2012.02.007
language
English
LU publication?
yes
id
d8034ce4-689f-4d62-9144-428366cd1335 (old id 3379478)
date added to LUP
2013-02-01 07:02:45
date last changed
2017-07-02 03:20:47
@article{d8034ce4-689f-4d62-9144-428366cd1335,
  abstract     = {Objective: To determine the association between radiographic osteoarthritis (OA) and pre-operative function in patients undergoing primary knee replacement. Methods: Single centre study examining pre-operative outcomes in a consecutive series of 525 patients who underwent primary knee replacement for OA between January 2006 and December 2007. Pre-operative data included: demographics, American Society of Anaesthesiologists (ASA) status and OA in the contralateral knee. The International Knee Society (IKS) rating and Short Form-12 (SF-12) were recorded for each patient. Pre-operative radiographs were read by a single observer for Kellgren and Lawrence (K&L) grading and Osteoarthritis Research Society International (OARSI) atlas features. Multiple linear regression was used to assess the strength of associations between radiographic OA severity and function, adjusting for clinically relevant variables. Results: Lateral tibiofemoral osteophyte grade was an independent predictor of pre-operative function as determined by the functional sub-scale of the IKS in patients undergoing primary knee replacement (coefficient = 2.58, p = 0.033). No associations were evident between pre-operative function and modified K&L, joint space narrowing, Ahlback attrition and coronal plane deformity. Other statistically significant predictors of poorer pre-operative function included: advancing age, female gender, knee pain and poorer SF-12 mental component summary scores which including osteophyte grade accounted for 24.6% of the variation in functional scores, (r = 0.496). Conclusion: Osteophytes in the lateral compartment of the knee were associated with pre-operative function in patients with advanced knee OA. Further studies are required which examine individual radiographic features specifically in patients with advanced knee OA to determine their relationship to pre-operative pain and function. (C) 2012 Elsevier B.V. All rights reserved.},
  author       = {Dowsey, Michelle M. and Dieppe, Paul and Lohmander, Stefan and Castle, David and Liew, Danny and Choong, Peter F. M.},
  issn         = {1873-5800},
  keyword      = {Osteoarthritis,Total knee replacement,Radiographic OA severity,Pre-operative function},
  language     = {eng},
  number       = {6},
  pages        = {860--865},
  publisher    = {Elsevier},
  series       = {Knee},
  title        = {The association between radiographic severity and pre-operative function in patients undergoing primary knee replacement for osteoarthritis},
  url          = {http://dx.doi.org/10.1016/j.knee.2012.02.007},
  volume       = {19},
  year         = {2012},
}