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Building authentic midbrain dopaminergic neurons from stem cells - lessons from development

Kirkeby, Agnete LU and Parmar, Malin LU (2012) In Translational Neuroscience 3(4). p.314-319
Abstract
The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Stem cells, Dopaminergic neurons, Differentiation, Development
in
Translational Neuroscience
volume
3
issue
4
pages
314 - 319
publisher
Versita
external identifiers
  • wos:000311519900002
  • scopus:84871421869
ISSN
2081-6936
DOI
10.2478/s13380-012-0041-x
language
English
LU publication?
yes
id
42be4248-6481-4c60-87d7-bf8b34f29e26 (old id 3379547)
date added to LUP
2013-02-01 06:55:56
date last changed
2017-01-01 03:36:22
@article{42be4248-6481-4c60-87d7-bf8b34f29e26,
  abstract     = {The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.},
  author       = {Kirkeby, Agnete and Parmar, Malin},
  issn         = {2081-6936},
  keyword      = {Stem cells,Dopaminergic neurons,Differentiation,Development},
  language     = {eng},
  number       = {4},
  pages        = {314--319},
  publisher    = {Versita},
  series       = {Translational Neuroscience},
  title        = {Building authentic midbrain dopaminergic neurons from stem cells - lessons from development},
  url          = {http://dx.doi.org/10.2478/s13380-012-0041-x},
  volume       = {3},
  year         = {2012},
}