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Effects of oxymetazoline on the ventilation of paranasal sinuses in healthy subjects

Paulsson, B; Lindberg, Sven LU and Ohlin, P (2002) In American Journal of Rhinology 16(2). p.125-129
Abstract
Background: Impairment of sinus ostial function is considered an important factor in the pathophysiology of sinus disease. The use of the decongestants such as alpha2-agonists is thought to improve sinus ostial function. Previous studies have shown an effect of alpha2-agonists on maxillary sinus ostial function only when administered in nasal bellows, but not as a nasal spray or nasal drops. The effect of decongestants on ventilation of the frontal and posterior ethmoidal and sphenoidal sinuses has not been studied to date. Methods: In this study, the 133-xenon washout method was used to determine ventilation for all paranasal sinuses before and after administration of oxymetazoline as nasal drops in eight subjects and from nasal bellows... (More)
Background: Impairment of sinus ostial function is considered an important factor in the pathophysiology of sinus disease. The use of the decongestants such as alpha2-agonists is thought to improve sinus ostial function. Previous studies have shown an effect of alpha2-agonists on maxillary sinus ostial function only when administered in nasal bellows, but not as a nasal spray or nasal drops. The effect of decongestants on ventilation of the frontal and posterior ethmoidal and sphenoidal sinuses has not been studied to date. Methods: In this study, the 133-xenon washout method was used to determine ventilation for all paranasal sinuses before and after administration of oxymetazoline as nasal drops in eight subjects and from nasal bellows in nine healthy subjects. Results: No significant effect of oxymetazoline on sinus ventilation was seen in either group. Conclusions: The results indicate that alpha2-agonists do not have any effect on sinus ventilation in healthy subjects. However, one cannot exclude that decongestants improve sinus ventilation in patients suffering from sinus disease and this requires further studies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Rhinology
volume
16
issue
2
pages
125 - 129
publisher
OceanSide Publications, Inc
external identifiers
  • wos:000175432500010
  • scopus:0035999868
ISSN
1050-6586
language
English
LU publication?
yes
id
2de4e4d4-e0da-438b-b4b0-f775996a3222 (old id 338457)
alternative location
http://www.ingentaconnect.com/content/ocean/ajr/2002/00000016/00000002/art00010
date added to LUP
2007-11-08 12:27:10
date last changed
2017-01-01 05:12:28
@article{2de4e4d4-e0da-438b-b4b0-f775996a3222,
  abstract     = {Background: Impairment of sinus ostial function is considered an important factor in the pathophysiology of sinus disease. The use of the decongestants such as alpha2-agonists is thought to improve sinus ostial function. Previous studies have shown an effect of alpha2-agonists on maxillary sinus ostial function only when administered in nasal bellows, but not as a nasal spray or nasal drops. The effect of decongestants on ventilation of the frontal and posterior ethmoidal and sphenoidal sinuses has not been studied to date. Methods: In this study, the 133-xenon washout method was used to determine ventilation for all paranasal sinuses before and after administration of oxymetazoline as nasal drops in eight subjects and from nasal bellows in nine healthy subjects. Results: No significant effect of oxymetazoline on sinus ventilation was seen in either group. Conclusions: The results indicate that alpha2-agonists do not have any effect on sinus ventilation in healthy subjects. However, one cannot exclude that decongestants improve sinus ventilation in patients suffering from sinus disease and this requires further studies.},
  author       = {Paulsson, B and Lindberg, Sven and Ohlin, P},
  issn         = {1050-6586},
  language     = {eng},
  number       = {2},
  pages        = {125--129},
  publisher    = {OceanSide Publications, Inc},
  series       = {American Journal of Rhinology},
  title        = {Effects of oxymetazoline on the ventilation of paranasal sinuses in healthy subjects},
  volume       = {16},
  year         = {2002},
}