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Arsenic Exposure through Drinking Water Is Associated with Longer Telomeres in Peripheral Blood

Li, Huiqi LU ; Engström, Karin LU ; Vahter, Marie and Broberg Palmgren, Karin LU (2012) In Chemical Research in Toxicology 25(11). p.2333-2339
Abstract
Inorganic arsenic is a strong carcinogen, possibly by interaction with the telomere length. The aim of the study was to evaluate how chronic arsenic exposure from drinking water as well as the arsenic metabolism efficiency affect the individual telomere length and the expression of telomere-related genes. Two hundred two women with a wide range in exposure to arsenic via drinking water (3.5-200 mu g/L) were recruited. Concentrations of arsenic metabolites in urine [inorganic arsenic (iAs), methylarsonic acid (MMA), and dimethylarsinic acid (DMA)] were measured. The relative telomere length in blood was measured by quantitative real-time polymerase chain reaction. Genotyping (N = 172) for eight SNPs in AS3MT and gene expression of... (More)
Inorganic arsenic is a strong carcinogen, possibly by interaction with the telomere length. The aim of the study was to evaluate how chronic arsenic exposure from drinking water as well as the arsenic metabolism efficiency affect the individual telomere length and the expression of telomere-related genes. Two hundred two women with a wide range in exposure to arsenic via drinking water (3.5-200 mu g/L) were recruited. Concentrations of arsenic metabolites in urine [inorganic arsenic (iAs), methylarsonic acid (MMA), and dimethylarsinic acid (DMA)] were measured. The relative telomere length in blood was measured by quantitative real-time polymerase chain reaction. Genotyping (N = 172) for eight SNPs in AS3MT and gene expression of telomere-related genes (in blood; N = 90) were performed. Urinary arsenic (sum of metabolites) was positively associated with telomere length (beta = 0.65 x 10(-4), 95% CI = 0.031 x 10(-4)-1.3 x 10(-4), adjusted for age and BMI). Individuals with above median fractions of iAs and MMA showed significantly longer telomeres by increasing urinary arsenic (beta = 1.0 x 10(-4), 95% CI = 0.21 x 10(-4)-1.8 x 10(-4) at high % iAs; beta = 0.88 x 10(-4) 95% CI = 0.12 x 10(-4)-1.6 x 10(-4) at high % MMA) than those below the median (p = 0.80 and 0.44, respectively). Similarly, carriers of the slow and more toxic metabolizing AS3MT haplotype showed stronger positive associations between arsenic exposure and telomere length, as compared to noncarriers (interaction urinary arsenic and haplotype p = 0.025). Urinary arsenic was positively correlated with the expression of telomerase reverse transcriptase (TERT, Spearman r = 0.22, p = 0.037), but no association was found between TERT expression and telomere length. Arsenic in drinking water influences the telomere length, and this may be a mechanism for its carcinogenicity. A faster and less toxic arsenic metabolism diminishes arsenic-related telomere elongation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemical Research in Toxicology
volume
25
issue
11
pages
2333 - 2339
publisher
The American Chemical Society
external identifiers
  • wos:000311173800006
  • scopus:84869459434
ISSN
1520-5010
DOI
10.1021/tx300222t
language
English
LU publication?
yes
id
460e1664-3252-4920-80b3-9a5fe47d0ee3 (old id 3388298)
date added to LUP
2013-02-01 07:03:44
date last changed
2017-11-19 03:20:32
@article{460e1664-3252-4920-80b3-9a5fe47d0ee3,
  abstract     = {Inorganic arsenic is a strong carcinogen, possibly by interaction with the telomere length. The aim of the study was to evaluate how chronic arsenic exposure from drinking water as well as the arsenic metabolism efficiency affect the individual telomere length and the expression of telomere-related genes. Two hundred two women with a wide range in exposure to arsenic via drinking water (3.5-200 mu g/L) were recruited. Concentrations of arsenic metabolites in urine [inorganic arsenic (iAs), methylarsonic acid (MMA), and dimethylarsinic acid (DMA)] were measured. The relative telomere length in blood was measured by quantitative real-time polymerase chain reaction. Genotyping (N = 172) for eight SNPs in AS3MT and gene expression of telomere-related genes (in blood; N = 90) were performed. Urinary arsenic (sum of metabolites) was positively associated with telomere length (beta = 0.65 x 10(-4), 95% CI = 0.031 x 10(-4)-1.3 x 10(-4), adjusted for age and BMI). Individuals with above median fractions of iAs and MMA showed significantly longer telomeres by increasing urinary arsenic (beta = 1.0 x 10(-4), 95% CI = 0.21 x 10(-4)-1.8 x 10(-4) at high % iAs; beta = 0.88 x 10(-4) 95% CI = 0.12 x 10(-4)-1.6 x 10(-4) at high % MMA) than those below the median (p = 0.80 and 0.44, respectively). Similarly, carriers of the slow and more toxic metabolizing AS3MT haplotype showed stronger positive associations between arsenic exposure and telomere length, as compared to noncarriers (interaction urinary arsenic and haplotype p = 0.025). Urinary arsenic was positively correlated with the expression of telomerase reverse transcriptase (TERT, Spearman r = 0.22, p = 0.037), but no association was found between TERT expression and telomere length. Arsenic in drinking water influences the telomere length, and this may be a mechanism for its carcinogenicity. A faster and less toxic arsenic metabolism diminishes arsenic-related telomere elongation.},
  author       = {Li, Huiqi and Engström, Karin and Vahter, Marie and Broberg Palmgren, Karin},
  issn         = {1520-5010},
  language     = {eng},
  number       = {11},
  pages        = {2333--2339},
  publisher    = {The American Chemical Society},
  series       = {Chemical Research in Toxicology},
  title        = {Arsenic Exposure through Drinking Water Is Associated with Longer Telomeres in Peripheral Blood},
  url          = {http://dx.doi.org/10.1021/tx300222t},
  volume       = {25},
  year         = {2012},
}