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Early amniocentesis and congenital foot deformities

Nikkilä, Annamari LU ; Valentin, Lil LU ; Thelin, A and Jorgensen, C (2002) In Fetal Diagnosis and Therapy 17(3). p.129-132
Abstract
Objective: Several studies have shown an increased risk of congenital foot derformities after early amniocentesis. These studies have comprised amniocenteses performed before 13 completed gestational weeks. In this study, the risk of foot deformities after amniocentesis performed at 12-14 completed gestational weeks was determined. Methods: 3,469 genetic amniocenteses in singleton pregnancies performed before 15 completed gestational weeks were studied. The intention was to perform the amniocenteses at 12-14 weeks of gestation, but 32 amniocenteses were performed at the gestational age 11 weeks + 5 days or 11 weeks + 6 days. The pregnancies were followed up with regard to fetal loss and leakage of amniotic fluid. After birth, newborns with... (More)
Objective: Several studies have shown an increased risk of congenital foot derformities after early amniocentesis. These studies have comprised amniocenteses performed before 13 completed gestational weeks. In this study, the risk of foot deformities after amniocentesis performed at 12-14 completed gestational weeks was determined. Methods: 3,469 genetic amniocenteses in singleton pregnancies performed before 15 completed gestational weeks were studied. The intention was to perform the amniocenteses at 12-14 weeks of gestation, but 32 amniocenteses were performed at the gestational age 11 weeks + 5 days or 11 weeks + 6 days. The pregnancies were followed up with regard to fetal loss and leakage of amniotic fluid. After birth, newborns with a diagnosis of foot deformity were identified from the Swedish Medical Birth Registry. The observed number of foot deformities was then compared with the expected number which was calculated stratified for delivery hospital, year of birth, and maternal age. Results: The observed number of foot deformities was significantly higher than the expected: exact odds ratio 1.74 (exact 95% confidence interval 1.06-2.69). The rate of spontaneous abortions after the procedure was 1.8%, and the rate of leakage of amniotic fluid was 1.9%. There was a significant trend for all complications to decrease with increasing gestational age at amniocentesis. Conclusion: Women undergoing amniocentesis at 11 + 5 to 14 + 6 gestational weeks have an increased risk of giving birth to a child with a congenital foot deformity. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
early amniocentesis, congenital foot deformities, talipes
in
Fetal Diagnosis and Therapy
volume
17
issue
3
pages
129 - 132
publisher
Karger
external identifiers
  • wos:000175254800001
  • scopus:0036206209
ISSN
1015-3837
language
English
LU publication?
yes
id
53f9cce8-86e6-4771-823c-2169cb00db1f (old id 339615)
alternative location
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ProduktNr=224239&Ausgabe=227539&ArtikelNr=48024&filename=48024.pdf
date added to LUP
2007-11-02 13:25:11
date last changed
2017-01-01 04:44:41
@article{53f9cce8-86e6-4771-823c-2169cb00db1f,
  abstract     = {Objective: Several studies have shown an increased risk of congenital foot derformities after early amniocentesis. These studies have comprised amniocenteses performed before 13 completed gestational weeks. In this study, the risk of foot deformities after amniocentesis performed at 12-14 completed gestational weeks was determined. Methods: 3,469 genetic amniocenteses in singleton pregnancies performed before 15 completed gestational weeks were studied. The intention was to perform the amniocenteses at 12-14 weeks of gestation, but 32 amniocenteses were performed at the gestational age 11 weeks + 5 days or 11 weeks + 6 days. The pregnancies were followed up with regard to fetal loss and leakage of amniotic fluid. After birth, newborns with a diagnosis of foot deformity were identified from the Swedish Medical Birth Registry. The observed number of foot deformities was then compared with the expected number which was calculated stratified for delivery hospital, year of birth, and maternal age. Results: The observed number of foot deformities was significantly higher than the expected: exact odds ratio 1.74 (exact 95% confidence interval 1.06-2.69). The rate of spontaneous abortions after the procedure was 1.8%, and the rate of leakage of amniotic fluid was 1.9%. There was a significant trend for all complications to decrease with increasing gestational age at amniocentesis. Conclusion: Women undergoing amniocentesis at 11 + 5 to 14 + 6 gestational weeks have an increased risk of giving birth to a child with a congenital foot deformity.},
  author       = {Nikkilä, Annamari and Valentin, Lil and Thelin, A and Jorgensen, C},
  issn         = {1015-3837},
  keyword      = {early amniocentesis,congenital foot deformities,talipes},
  language     = {eng},
  number       = {3},
  pages        = {129--132},
  publisher    = {Karger},
  series       = {Fetal Diagnosis and Therapy},
  title        = {Early amniocentesis and congenital foot deformities},
  volume       = {17},
  year         = {2002},
}