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A facile method for preparing molecularly imprinted polymer spheres using spherical silica templates

Yilmaz, Ecevit LU ; Ramstrom, O; Moller, P; Sanchez, D and Mosbach, Klaus LU (2002) In Journal of Materials Chemistry 12(5). p.1577-1581
Abstract
A novel and facile preparation method for spherical molecularly imprinted polymer (MIP) beads is presented. Two types of beads were synthesized and investigated: (i) silica-MIP composites were obtained by filling spherical, porous C-4-coated silica beads with print molecule and monomers followed by polymerisation; (ii) spherical molecularly imprinted polymer beads were acquired mirroring the silica particles in size, shape and pore structure by removing the silica matrix from the silica-MIP composites. With regard to their chromatographic properties and yield of the materials both types of particle were more advantageous compared to irregularly shaped traditional MIPs. Also the work-up time to obtain imprinted spherical particles is... (More)
A novel and facile preparation method for spherical molecularly imprinted polymer (MIP) beads is presented. Two types of beads were synthesized and investigated: (i) silica-MIP composites were obtained by filling spherical, porous C-4-coated silica beads with print molecule and monomers followed by polymerisation; (ii) spherical molecularly imprinted polymer beads were acquired mirroring the silica particles in size, shape and pore structure by removing the silica matrix from the silica-MIP composites. With regard to their chromatographic properties and yield of the materials both types of particle were more advantageous compared to irregularly shaped traditional MIPs. Also the work-up time to obtain imprinted spherical particles is greatly reduced compared to traditional methods using polymer monoliths, which have to be ground, sieved and sedimented. Generally, the described method may open new possibilities for synthesis of novel types of imprinted polymer formats such as membranes, bulk polymers, films or in-situ columns using appropriate support or sacrificial materials. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Materials Chemistry
volume
12
issue
5
pages
1577 - 1581
publisher
Royal Society of Chemistry
external identifiers
  • wos:000175143000062
  • scopus:0036097274
ISSN
1364-5501
DOI
10.1039/b109262f
language
English
LU publication?
yes
id
d6e392ab-72d9-4488-9465-b69d9fd975f6 (old id 339921)
date added to LUP
2007-11-16 15:04:26
date last changed
2017-08-27 03:47:15
@article{d6e392ab-72d9-4488-9465-b69d9fd975f6,
  abstract     = {A novel and facile preparation method for spherical molecularly imprinted polymer (MIP) beads is presented. Two types of beads were synthesized and investigated: (i) silica-MIP composites were obtained by filling spherical, porous C-4-coated silica beads with print molecule and monomers followed by polymerisation; (ii) spherical molecularly imprinted polymer beads were acquired mirroring the silica particles in size, shape and pore structure by removing the silica matrix from the silica-MIP composites. With regard to their chromatographic properties and yield of the materials both types of particle were more advantageous compared to irregularly shaped traditional MIPs. Also the work-up time to obtain imprinted spherical particles is greatly reduced compared to traditional methods using polymer monoliths, which have to be ground, sieved and sedimented. Generally, the described method may open new possibilities for synthesis of novel types of imprinted polymer formats such as membranes, bulk polymers, films or in-situ columns using appropriate support or sacrificial materials.},
  author       = {Yilmaz, Ecevit and Ramstrom, O and Moller, P and Sanchez, D and Mosbach, Klaus},
  issn         = {1364-5501},
  language     = {eng},
  number       = {5},
  pages        = {1577--1581},
  publisher    = {Royal Society of Chemistry},
  series       = {Journal of Materials Chemistry},
  title        = {A facile method for preparing molecularly imprinted polymer spheres using spherical silica templates},
  url          = {http://dx.doi.org/10.1039/b109262f},
  volume       = {12},
  year         = {2002},
}