Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.
(2013) In The Lancet Respiratory Medicine 1(9). p.714-727- Abstract
- Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bronchodilator and anti-inflammatory drug.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4291379
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Lancet Respiratory Medicine
- volume
- 1
- issue
- 9
- pages
- 714 - 727
- publisher
- Elsevier
- external identifiers
-
- pmid:24429275
- wos:000342691000020
- scopus:84887115924
- ISSN
- 2213-2600
- DOI
- 10.1016/S2213-2600(13)70187-5
- language
- English
- LU publication?
- yes
- id
- 33b40e8f-608d-4097-84a8-36f3bd11be2c (old id 4291379)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24429275?dopt=Abstract
- date added to LUP
- 2016-04-01 14:07:22
- date last changed
- 2022-03-29 19:12:47
@article{33b40e8f-608d-4097-84a8-36f3bd11be2c, abstract = {{Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bronchodilator and anti-inflammatory drug.}}, author = {{Franciosi, Lui G and Diamant, Zuzana and Banner, Katharine H and Zuiker, Rob and Morelli, Nicoletta and Kamerling, Ingrid M C and de Kam, Marieke L and Burggraaf, Jacobus and Cohen, Adam F and Cazzola, Mario and Calzetta, Luigino and Singh, Dave and Spina, Domenico and Walker, Michael J A and Page, Clive P}}, issn = {{2213-2600}}, language = {{eng}}, number = {{9}}, pages = {{714--727}}, publisher = {{Elsevier}}, series = {{The Lancet Respiratory Medicine}}, title = {{Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.}}, url = {{http://dx.doi.org/10.1016/S2213-2600(13)70187-5}}, doi = {{10.1016/S2213-2600(13)70187-5}}, volume = {{1}}, year = {{2013}}, }