Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood
(2008) In Pediatric Pulmonology 43(6). p.75-567- Abstract
Mycoplasma (M.) pneumoniae has been associated with exacerbation of symptoms in asthmatic school children and adults; and an etiological role in asthma has been suggested. The purpose of this study was to investigate whether infection with M. pneumoniae in early childhood has a long-term influence on lung function and bronchial responsiveness. In a retrospective, clinical cohort-study children younger than 5 years-of-age when PCR-tested for M. pneumoniae were enrolled. Sixty-five children with clinical symptoms suggesting infection with M. pneumoniae during an epidemic season completed a clinical follow-up examination including lung function testing (28 PCR-positive and 37 PCR-negative). In addition to the PCR-test for M. pneumoniae all... (More)
Mycoplasma (M.) pneumoniae has been associated with exacerbation of symptoms in asthmatic school children and adults; and an etiological role in asthma has been suggested. The purpose of this study was to investigate whether infection with M. pneumoniae in early childhood has a long-term influence on lung function and bronchial responsiveness. In a retrospective, clinical cohort-study children younger than 5 years-of-age when PCR-tested for M. pneumoniae were enrolled. Sixty-five children with clinical symptoms suggesting infection with M. pneumoniae during an epidemic season completed a clinical follow-up examination including lung function testing (28 PCR-positive and 37 PCR-negative). In addition to the PCR-test for M. pneumoniae all respiratory tract specimens were additionally tested for other atypical bacteria and for viruses by PCR. Lung function was measured as specific airway resistance by whole-body plethysmography and bronchial hyperresponsiveness was assessed by cold, dry air hyperventilation. Neither baseline lung function nor bronchial response to cold dry air hyperventilation differed between M. pneumoniae-positive and -negative children: mean baseline lung function were 1.17 versus 1.21 (kPa sec), P = 0.45; and mean change in specific resistance was 13% versus 9%, P = 0.42. In conclusion, M. pneumoniae infection in early childhood was not associated with long-term effects on lung function and bronchial hyperresponsiveness 2 years after infection.
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- author
- Kjaer, Birgitte B ; Jensen, Jørgen S ; Nielsen, Kim G ; Fomsgaard, Anders ; Böttiger, Blenda LU ; Dohn, Birthe and Bisgaard, Hans
- publishing date
- 2008-06
- type
- Contribution to journal
- publication status
- published
- keywords
- Airway Resistance, Bronchial Hyperreactivity/diagnosis, Bronchial Provocation Tests, Child, Preschool, Cohort Studies, Female, Humans, Infant, Male, Mycoplasma Infections/complications, Mycoplasma pneumoniae/isolation & purification, Plethysmography, Whole Body, Polymerase Chain Reaction, Retrospective Studies
- in
- Pediatric Pulmonology
- volume
- 43
- issue
- 6
- pages
- 75 - 567
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:18435477
- scopus:44949217570
- ISSN
- 8755-6863
- DOI
- 10.1002/ppul.20813
- language
- English
- LU publication?
- no
- id
- 33c52471-3dc3-44d5-af52-3da5ab291afb
- date added to LUP
- 2019-05-02 14:22:53
- date last changed
- 2025-01-09 07:09:51
@article{33c52471-3dc3-44d5-af52-3da5ab291afb,
abstract = {{<p>Mycoplasma (M.) pneumoniae has been associated with exacerbation of symptoms in asthmatic school children and adults; and an etiological role in asthma has been suggested. The purpose of this study was to investigate whether infection with M. pneumoniae in early childhood has a long-term influence on lung function and bronchial responsiveness. In a retrospective, clinical cohort-study children younger than 5 years-of-age when PCR-tested for M. pneumoniae were enrolled. Sixty-five children with clinical symptoms suggesting infection with M. pneumoniae during an epidemic season completed a clinical follow-up examination including lung function testing (28 PCR-positive and 37 PCR-negative). In addition to the PCR-test for M. pneumoniae all respiratory tract specimens were additionally tested for other atypical bacteria and for viruses by PCR. Lung function was measured as specific airway resistance by whole-body plethysmography and bronchial hyperresponsiveness was assessed by cold, dry air hyperventilation. Neither baseline lung function nor bronchial response to cold dry air hyperventilation differed between M. pneumoniae-positive and -negative children: mean baseline lung function were 1.17 versus 1.21 (kPa sec), P = 0.45; and mean change in specific resistance was 13% versus 9%, P = 0.42. In conclusion, M. pneumoniae infection in early childhood was not associated with long-term effects on lung function and bronchial hyperresponsiveness 2 years after infection.</p>}},
author = {{Kjaer, Birgitte B and Jensen, Jørgen S and Nielsen, Kim G and Fomsgaard, Anders and Böttiger, Blenda and Dohn, Birthe and Bisgaard, Hans}},
issn = {{8755-6863}},
keywords = {{Airway Resistance; Bronchial Hyperreactivity/diagnosis; Bronchial Provocation Tests; Child, Preschool; Cohort Studies; Female; Humans; Infant; Male; Mycoplasma Infections/complications; Mycoplasma pneumoniae/isolation & purification; Plethysmography, Whole Body; Polymerase Chain Reaction; Retrospective Studies}},
language = {{eng}},
number = {{6}},
pages = {{75--567}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Pediatric Pulmonology}},
title = {{Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood}},
url = {{http://dx.doi.org/10.1002/ppul.20813}},
doi = {{10.1002/ppul.20813}},
volume = {{43}},
year = {{2008}},
}