Can birth weight predict offspring’s lung function in adult age? Evidence from two Swedish birth cohorts
Sakic, Aleksandra LU ; Ekström, Magnus LU
; Sharma, Shantanu
LU
and Nilsson, Peter M.
LU
(2022)
In Respiratory Research
23(1).
- Abstract
Background: Associations between birth weight (BW) and adult lung function have been inconsistent and limited to early adulthood. We aimed to study this association in two population-based cohorts and explore if BW, adjusted for gestational age, predicts adult lung function. We also tested adult lung function impairment according to the mis-match hypothesis—small babies growing big as adults. Methods: We included 3495 individuals (aged 46.4 ± 5.4 years) from the Malmo Preventive Project (MPP), Sweden, born between 1921 and 1949, and 1401 young to middle-aged individuals (aged 28.6 ± 6.7 years) from the Malmo Offspring Study (MOS) with complete data on BW and gestational age. Adult lung function (forced vital capacity [FVC], forced... (More)
Background: Associations between birth weight (BW) and adult lung function have been inconsistent and limited to early adulthood. We aimed to study this association in two population-based cohorts and explore if BW, adjusted for gestational age, predicts adult lung function. We also tested adult lung function impairment according to the mis-match hypothesis—small babies growing big as adults. Methods: We included 3495 individuals (aged 46.4 ± 5.4 years) from the Malmo Preventive Project (MPP), Sweden, born between 1921 and 1949, and 1401 young to middle-aged individuals (aged 28.6 ± 6.7 years) from the Malmo Offspring Study (MOS) with complete data on BW and gestational age. Adult lung function (forced vital capacity [FVC], forced expiratory volume in one second [FEV1] and the FEV1/FVC-ratio) were analysed as level of impairment (z-score), using multiple linear and logistic regressions. Results: BW (z-score) did not predict adult lung function in MPP, whereas BW was a significant (p = 0.003) predictor of FEV1 following full adjustment in MOS. For every additional unit increase in BW, children were 0.77 (95% CI 0.65–0.92) times less likely to have impaired adult lung function (FEV1). Moreover, adults born with lower BW (< 3510 g) showed improved lung function (FEV1 and FEV1/FVC in MOS and MPP, respectively) if they achieved higher adult body weight. Conclusions: Adults born with lower birth weight, adjusted for gestational age, are more likely to have impaired lung function, seen in a younger birth cohort. Postnatal growth pattern may, however, compensate for low birth weight and contribute to better adult lung function.
(Less)
- author
- Sakic, Aleksandra
LU
; Ekström, Magnus
LU
; Sharma, Shantanu
LU
and Nilsson, Peter M.
LU
- organization
- publishing date
- 2022-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Birth weight, Cohort, Epidemiology, Gestational age, Lung function
- in
- Respiratory Research
- volume
- 23
- issue
- 1
- article number
- 348
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85144238011
- pmid:36522741
- ISSN
- 1465-9921
- DOI
- 10.1186/s12931-022-02269-2
- language
- English
- LU publication?
- yes
- id
- 33eeccef-1ab3-480f-b47f-d7b56bc89609
- date added to LUP
- 2023-01-10 15:31:58
- date last changed
- 2024-04-18 10:06:27
@article{33eeccef-1ab3-480f-b47f-d7b56bc89609,
abstract = {{<p>Background: Associations between birth weight (BW) and adult lung function have been inconsistent and limited to early adulthood. We aimed to study this association in two population-based cohorts and explore if BW, adjusted for gestational age, predicts adult lung function. We also tested adult lung function impairment according to the mis-match hypothesis—small babies growing big as adults. Methods: We included 3495 individuals (aged 46.4 ± 5.4 years) from the Malmo Preventive Project (MPP), Sweden, born between 1921 and 1949, and 1401 young to middle-aged individuals (aged 28.6 ± 6.7 years) from the Malmo Offspring Study (MOS) with complete data on BW and gestational age. Adult lung function (forced vital capacity [FVC], forced expiratory volume in one second [FEV1] and the FEV1/FVC-ratio) were analysed as level of impairment (z-score), using multiple linear and logistic regressions. Results: BW (z-score) did not predict adult lung function in MPP, whereas BW was a significant (p = 0.003) predictor of FEV1 following full adjustment in MOS. For every additional unit increase in BW, children were 0.77 (95% CI 0.65–0.92) times less likely to have impaired adult lung function (FEV1). Moreover, adults born with lower BW (< 3510 g) showed improved lung function (FEV1 and FEV1/FVC in MOS and MPP, respectively) if they achieved higher adult body weight. Conclusions: Adults born with lower birth weight, adjusted for gestational age, are more likely to have impaired lung function, seen in a younger birth cohort. Postnatal growth pattern may, however, compensate for low birth weight and contribute to better adult lung function.</p>}},
author = {{Sakic, Aleksandra and Ekström, Magnus and Sharma, Shantanu and Nilsson, Peter M.}},
issn = {{1465-9921}},
keywords = {{Birth weight; Cohort; Epidemiology; Gestational age; Lung function}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Respiratory Research}},
title = {{Can birth weight predict offspring’s lung function in adult age? Evidence from two Swedish birth cohorts}},
url = {{http://dx.doi.org/10.1186/s12931-022-02269-2}},
doi = {{10.1186/s12931-022-02269-2}},
volume = {{23}},
year = {{2022}},
}