Advanced

An evolutionary analysis of the aetiology and pathogenesis of juvenile-onset myopia

Cordain, L; Eaton, SB; Miller, JB; Lindeberg, Staffan LU and Jensen, C (2002) In Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00 80(2). p.125-135
Abstract
The available evidence suggests that both genes and environment play a crucial role in the development of juvenile-onset myopia. When the human visual system is examined from an evolutionary perspective, it becomes apparent that humans, living in the original environmental niche for which our species is genetically adapted (as hunter-gatherers), are either slightly hypermetropic or emmetropic and rarely develop myopia. Myopia occurs when novel environmental conditions associated with modern civilization are introduced into the hunter-gatherer lifestyle. The excessive near work of reading is most frequently cited as the main environmental stressor underlying the development of myopia. In this review we point out how a previously... (More)
The available evidence suggests that both genes and environment play a crucial role in the development of juvenile-onset myopia. When the human visual system is examined from an evolutionary perspective, it becomes apparent that humans, living in the original environmental niche for which our species is genetically adapted (as hunter-gatherers), are either slightly hypermetropic or emmetropic and rarely develop myopia. Myopia occurs when novel environmental conditions associated with modern civilization are introduced into the hunter-gatherer lifestyle. The excessive near work of reading is most frequently cited as the main environmental stressor underlying the development of myopia. In this review we point out how a previously unrecognized diet-related malady (chronic hyperinsulinaemia) may play a key role in the pathogenesis of juvenile-onset myopia because of its interaction with hormonal regulation of vitreal chamber growth. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
insulin like growth, factor binding protein 3 (IGFBP-3), insulin like growth factor I (IGF-1), gatherers, hunter, retinoid X receptors (RXR), retinoic acid receptors (RAR), retinoic acid (RA), insulin resistance, myopia, form deprivation
in
Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00
volume
80
issue
2
pages
125 - 135
publisher
Wiley-Blackwell
external identifiers
  • wos:000175092800003
  • pmid:11952477
  • scopus:0036124111
ISSN
1395-3907
DOI
10.1034/j.1600-0420.2002.800203.x
language
English
LU publication?
yes
id
37ededc9-1665-4cdb-964c-17c09ef8fd12 (old id 340143)
date added to LUP
2007-08-02 14:42:18
date last changed
2017-11-19 04:05:34
@article{37ededc9-1665-4cdb-964c-17c09ef8fd12,
  abstract     = {The available evidence suggests that both genes and environment play a crucial role in the development of juvenile-onset myopia. When the human visual system is examined from an evolutionary perspective, it becomes apparent that humans, living in the original environmental niche for which our species is genetically adapted (as hunter-gatherers), are either slightly hypermetropic or emmetropic and rarely develop myopia. Myopia occurs when novel environmental conditions associated with modern civilization are introduced into the hunter-gatherer lifestyle. The excessive near work of reading is most frequently cited as the main environmental stressor underlying the development of myopia. In this review we point out how a previously unrecognized diet-related malady (chronic hyperinsulinaemia) may play a key role in the pathogenesis of juvenile-onset myopia because of its interaction with hormonal regulation of vitreal chamber growth.},
  author       = {Cordain, L and Eaton, SB and Miller, JB and Lindeberg, Staffan and Jensen, C},
  issn         = {1395-3907},
  keyword      = {insulin like growth,factor binding protein 3 (IGFBP-3),insulin like growth factor I (IGF-1),gatherers,hunter,retinoid X receptors (RXR),retinoic acid receptors (RAR),retinoic acid (RA),insulin resistance,myopia,form deprivation},
  language     = {eng},
  number       = {2},
  pages        = {125--135},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00},
  title        = {An evolutionary analysis of the aetiology and pathogenesis of juvenile-onset myopia},
  url          = {http://dx.doi.org/10.1034/j.1600-0420.2002.800203.x},
  volume       = {80},
  year         = {2002},
}