An evolutionary analysis of the aetiology and pathogenesis of juvenile-onset myopia
(2002) In Acta Ophthalmologica Scandinavica 80(2). p.125-135- Abstract
- The available evidence suggests that both genes and environment play a crucial role in the development of juvenile-onset myopia. When the human visual system is examined from an evolutionary perspective, it becomes apparent that humans, living in the original environmental niche for which our species is genetically adapted (as hunter-gatherers), are either slightly hypermetropic or emmetropic and rarely develop myopia. Myopia occurs when novel environmental conditions associated with modern civilization are introduced into the hunter-gatherer lifestyle. The excessive near work of reading is most frequently cited as the main environmental stressor underlying the development of myopia. In this review we point out how a previously... (More)
- The available evidence suggests that both genes and environment play a crucial role in the development of juvenile-onset myopia. When the human visual system is examined from an evolutionary perspective, it becomes apparent that humans, living in the original environmental niche for which our species is genetically adapted (as hunter-gatherers), are either slightly hypermetropic or emmetropic and rarely develop myopia. Myopia occurs when novel environmental conditions associated with modern civilization are introduced into the hunter-gatherer lifestyle. The excessive near work of reading is most frequently cited as the main environmental stressor underlying the development of myopia. In this review we point out how a previously unrecognized diet-related malady (chronic hyperinsulinaemia) may play a key role in the pathogenesis of juvenile-onset myopia because of its interaction with hormonal regulation of vitreal chamber growth. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/340143
- author
- Cordain, L ; Eaton, SB ; Miller, JB ; Lindeberg, Staffan LU and Jensen, C
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- insulin like growth, factor binding protein 3 (IGFBP-3), insulin like growth factor I (IGF-1), gatherers, hunter, retinoid X receptors (RXR), retinoic acid receptors (RAR), retinoic acid (RA), insulin resistance, myopia, form deprivation
- in
- Acta Ophthalmologica Scandinavica
- volume
- 80
- issue
- 2
- pages
- 125 - 135
- publisher
- Wiley
- external identifiers
-
- wos:000175092800003
- pmid:11952477
- scopus:0036124111
- ISSN
- 1395-3907
- DOI
- 10.1034/j.1600-0420.2002.800203.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Community Medicine (013241810), Psychiatry/Primary Care/Public Health (013240500)
- id
- 37ededc9-1665-4cdb-964c-17c09ef8fd12 (old id 340143)
- date added to LUP
- 2016-04-01 15:44:38
- date last changed
- 2022-05-08 05:10:01
@article{37ededc9-1665-4cdb-964c-17c09ef8fd12,
abstract = {{The available evidence suggests that both genes and environment play a crucial role in the development of juvenile-onset myopia. When the human visual system is examined from an evolutionary perspective, it becomes apparent that humans, living in the original environmental niche for which our species is genetically adapted (as hunter-gatherers), are either slightly hypermetropic or emmetropic and rarely develop myopia. Myopia occurs when novel environmental conditions associated with modern civilization are introduced into the hunter-gatherer lifestyle. The excessive near work of reading is most frequently cited as the main environmental stressor underlying the development of myopia. In this review we point out how a previously unrecognized diet-related malady (chronic hyperinsulinaemia) may play a key role in the pathogenesis of juvenile-onset myopia because of its interaction with hormonal regulation of vitreal chamber growth.}},
author = {{Cordain, L and Eaton, SB and Miller, JB and Lindeberg, Staffan and Jensen, C}},
issn = {{1395-3907}},
keywords = {{insulin like growth; factor binding protein 3 (IGFBP-3); insulin like growth factor I (IGF-1); gatherers; hunter; retinoid X receptors (RXR); retinoic acid receptors (RAR); retinoic acid (RA); insulin resistance; myopia; form deprivation}},
language = {{eng}},
number = {{2}},
pages = {{125--135}},
publisher = {{Wiley}},
series = {{Acta Ophthalmologica Scandinavica}},
title = {{An evolutionary analysis of the aetiology and pathogenesis of juvenile-onset myopia}},
url = {{http://dx.doi.org/10.1034/j.1600-0420.2002.800203.x}},
doi = {{10.1034/j.1600-0420.2002.800203.x}},
volume = {{80}},
year = {{2002}},
}