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Effects of CO2 anaesthesia on central nervous system activity in swine

Martoft, L; Lomholt, L; Kolthoff, C; Rodriguez, BE; Jensen, EW; Jorgensen, PF; Pedersen, HD and Forslid, Anders LU (2002) In Laboratory Animals 36(2). p.115-126
Abstract
The objective of the study was to examine the changes in central nervous system (CNS) activity and physical behaviour during induction and awakening from CO2 anaesthesia. Two studies, each using pigs immersed into 90% CO2 gas for a period of 60s were performed. In study 1, we monitored middle latency auditory evoked potentials (changes in latencies, amplitudes and a depth of anaesthesia index), electroencephalographic parameters (delta, theta, alpha and beta electroencephalographic power and 95% spectral edge frequency) and heart rate; and in study 2, we monitored body movements and arterial and venous partial pressure of CO2 and O-2. No behavioural signs of distress were observed during the early part of the induction. The swine exhibited... (More)
The objective of the study was to examine the changes in central nervous system (CNS) activity and physical behaviour during induction and awakening from CO2 anaesthesia. Two studies, each using pigs immersed into 90% CO2 gas for a period of 60s were performed. In study 1, we monitored middle latency auditory evoked potentials (changes in latencies, amplitudes and a depth of anaesthesia index), electroencephalographic parameters (delta, theta, alpha and beta electroencephalographic power and 95% spectral edge frequency) and heart rate; and in study 2, we monitored body movements and arterial and venous partial pressure of CO2 and O-2. No behavioural signs of distress were observed during the early part of the induction. The swine exhibited muscular activity from 13-30s after induction-start as well as during awakening from anaesthesia, possibly because of a transitory weaker suppression of the brain stem than of the cortex. The CNS and blood gas parameters started to change from the very start of induction. The CNS suppression lasted only approximately one minute after the end of the induction period. The two studies indicated a good temporal relationship between changes in amplitude, depth of anaesthesia index, spectral edge frequency, and arterial P-CO2 during the induction period. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
carbon dioxide, depth, burst suppression, SEF, beta, alpha, theta, delta, EEG, auditory evoked potentials, CNS, MLAEP, P-CO2, P-O2 excitation, pig
in
Laboratory Animals
volume
36
issue
2
pages
115 - 126
publisher
Royal Society of Medicine Press
external identifiers
  • pmid:11943075
  • wos:000174939800002
  • scopus:0036010536
ISSN
0023-6772
language
English
LU publication?
yes
id
519ea596-f0a0-4155-a4b4-db902ffbcb6d (old id 340214)
alternative location
http://www.ingentaconnect.com/content/rsm/lab/2002/00000036/00000002/art00002
date added to LUP
2007-11-02 11:12:32
date last changed
2017-09-17 08:03:00
@article{519ea596-f0a0-4155-a4b4-db902ffbcb6d,
  abstract     = {The objective of the study was to examine the changes in central nervous system (CNS) activity and physical behaviour during induction and awakening from CO2 anaesthesia. Two studies, each using pigs immersed into 90% CO2 gas for a period of 60s were performed. In study 1, we monitored middle latency auditory evoked potentials (changes in latencies, amplitudes and a depth of anaesthesia index), electroencephalographic parameters (delta, theta, alpha and beta electroencephalographic power and 95% spectral edge frequency) and heart rate; and in study 2, we monitored body movements and arterial and venous partial pressure of CO2 and O-2. No behavioural signs of distress were observed during the early part of the induction. The swine exhibited muscular activity from 13-30s after induction-start as well as during awakening from anaesthesia, possibly because of a transitory weaker suppression of the brain stem than of the cortex. The CNS and blood gas parameters started to change from the very start of induction. The CNS suppression lasted only approximately one minute after the end of the induction period. The two studies indicated a good temporal relationship between changes in amplitude, depth of anaesthesia index, spectral edge frequency, and arterial P-CO2 during the induction period.},
  author       = {Martoft, L and Lomholt, L and Kolthoff, C and Rodriguez, BE and Jensen, EW and Jorgensen, PF and Pedersen, HD and Forslid, Anders},
  issn         = {0023-6772},
  keyword      = {carbon dioxide,depth,burst suppression,SEF,beta,alpha,theta,delta,EEG,auditory evoked potentials,CNS,MLAEP,P-CO2,P-O2 excitation,pig},
  language     = {eng},
  number       = {2},
  pages        = {115--126},
  publisher    = {Royal Society of Medicine Press},
  series       = {Laboratory Animals},
  title        = {Effects of CO2 anaesthesia on central nervous system activity in swine},
  volume       = {36},
  year         = {2002},
}