Suicide-attempters having immunoglobulin G with affinity for doparnine in cerebrospinal fluid
(2002) In European Neuropsychopharmacology 12(2). p.153-158- Abstract
- Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (DA) in cerebrospinal fluid (CSF) using ELISA. In CSF from 49 suicide attempters the titer of DA-IgG was significantly higher (P<0.001) than in CSF obtained from control subjects undergoing neurological investigation, The results in the present study indicate that an autoimmune mechanism may be involved in the dopaminergic neurotransmitter... (More)
- Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (DA) in cerebrospinal fluid (CSF) using ELISA. In CSF from 49 suicide attempters the titer of DA-IgG was significantly higher (P<0.001) than in CSF obtained from control subjects undergoing neurological investigation, The results in the present study indicate that an autoimmune mechanism may be involved in the dopaminergic neurotransmitter system and may be of pathophysiological importance in psychiatric disorders connected to an attempt of suicide, (C) 2002 Published by Elsevier Science BV/ECNP. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/340831
- author
- Bergquist, J ; Träskman Bendz, Lil LU ; Lindström, Mats LU and Ekman, R
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- suicide-attempters, cerebrospinal fluids, dopamine, IgG-antibodies, psychiatric disorders, autoimmunity
- in
- European Neuropsychopharmacology
- volume
- 12
- issue
- 2
- pages
- 153 - 158
- publisher
- Elsevier
- external identifiers
-
- wos:000174872300010
- pmid:11872333
- scopus:0036180159
- ISSN
- 1873-7862
- DOI
- 10.1016/S0924-977X(02)00002-0
- language
- English
- LU publication?
- yes
- id
- a6fdd3c5-c003-456e-a2c5-a582a13fd6a6 (old id 340831)
- date added to LUP
- 2016-04-01 11:50:07
- date last changed
- 2022-02-25 22:02:38
@article{a6fdd3c5-c003-456e-a2c5-a582a13fd6a6, abstract = {{Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (DA) in cerebrospinal fluid (CSF) using ELISA. In CSF from 49 suicide attempters the titer of DA-IgG was significantly higher (P<0.001) than in CSF obtained from control subjects undergoing neurological investigation, The results in the present study indicate that an autoimmune mechanism may be involved in the dopaminergic neurotransmitter system and may be of pathophysiological importance in psychiatric disorders connected to an attempt of suicide, (C) 2002 Published by Elsevier Science BV/ECNP.}}, author = {{Bergquist, J and Träskman Bendz, Lil and Lindström, Mats and Ekman, R}}, issn = {{1873-7862}}, keywords = {{suicide-attempters; cerebrospinal fluids; dopamine; IgG-antibodies; psychiatric disorders; autoimmunity}}, language = {{eng}}, number = {{2}}, pages = {{153--158}}, publisher = {{Elsevier}}, series = {{European Neuropsychopharmacology}}, title = {{Suicide-attempters having immunoglobulin G with affinity for doparnine in cerebrospinal fluid}}, url = {{http://dx.doi.org/10.1016/S0924-977X(02)00002-0}}, doi = {{10.1016/S0924-977X(02)00002-0}}, volume = {{12}}, year = {{2002}}, }