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Suicide-attempters having immunoglobulin G with affinity for doparnine in cerebrospinal fluid

Bergquist, J; Träskman Bendz, Lil LU ; Lindström, Mats LU and Ekman, R (2002) In European Neuropsychopharmacology 12(2). p.153-158
Abstract
Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (DA) in cerebrospinal fluid (CSF) using ELISA. In CSF from 49 suicide attempters the titer of DA-IgG was significantly higher (P<0.001) than in CSF obtained from control subjects undergoing neurological investigation, The results in the present study indicate that an autoimmune mechanism may be involved in the dopaminergic neurotransmitter... (More)
Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (DA) in cerebrospinal fluid (CSF) using ELISA. In CSF from 49 suicide attempters the titer of DA-IgG was significantly higher (P<0.001) than in CSF obtained from control subjects undergoing neurological investigation, The results in the present study indicate that an autoimmune mechanism may be involved in the dopaminergic neurotransmitter system and may be of pathophysiological importance in psychiatric disorders connected to an attempt of suicide, (C) 2002 Published by Elsevier Science BV/ECNP. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
suicide-attempters, cerebrospinal fluids, dopamine, IgG-antibodies, psychiatric disorders, autoimmunity
in
European Neuropsychopharmacology
volume
12
issue
2
pages
153 - 158
publisher
Elsevier
external identifiers
  • wos:000174872300010
  • pmid:11872333
  • scopus:0036180159
ISSN
1873-7862
DOI
10.1016/S0924-977X(02)00002-0
language
English
LU publication?
yes
id
a6fdd3c5-c003-456e-a2c5-a582a13fd6a6 (old id 340831)
date added to LUP
2007-08-09 15:34:51
date last changed
2017-05-21 03:33:12
@article{a6fdd3c5-c003-456e-a2c5-a582a13fd6a6,
  abstract     = {Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (DA) in cerebrospinal fluid (CSF) using ELISA. In CSF from 49 suicide attempters the titer of DA-IgG was significantly higher (P&lt;0.001) than in CSF obtained from control subjects undergoing neurological investigation, The results in the present study indicate that an autoimmune mechanism may be involved in the dopaminergic neurotransmitter system and may be of pathophysiological importance in psychiatric disorders connected to an attempt of suicide, (C) 2002 Published by Elsevier Science BV/ECNP.},
  author       = {Bergquist, J and Träskman Bendz, Lil and Lindström, Mats and Ekman, R},
  issn         = {1873-7862},
  keyword      = {suicide-attempters,cerebrospinal fluids,dopamine,IgG-antibodies,psychiatric disorders,autoimmunity},
  language     = {eng},
  number       = {2},
  pages        = {153--158},
  publisher    = {Elsevier},
  series       = {European Neuropsychopharmacology},
  title        = {Suicide-attempters having immunoglobulin G with affinity for doparnine in cerebrospinal fluid},
  url          = {http://dx.doi.org/10.1016/S0924-977X(02)00002-0},
  volume       = {12},
  year         = {2002},
}