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The P1PK blood group system : revisited and resolved

Stenfelt, Linn LU orcid ; Hellberg, Åsa LU ; Westman, Julia S. LU and Olsson, Martin L. LU orcid (2020) In Immunohematology 36(3). p.99-103
Abstract

CONCLUSIONS: This update on the P1PK blood group system (Hellberg Å, Westman JS, Thuresson B, Olsson ML. P1PK: the blood group system that changed its name and expanded. Immunohematology 2013;29:25-33) provides recent findings concerning the P1PK blood group system that have both challenged and confirmed old theories. The glycosphingolipids can no longer be considered the sole carriers of the antigens in this system because the P1 antigen has been detected on human red blood cell glycoproteins. New indications suggest that P1Pk synthase activity truly depends on the DXD motif, and the genetic background and molecular mechanism behind the common P1 and P2 phenotypes were found to depend on transcriptional regulation. Transcription... (More)

CONCLUSIONS: This update on the P1PK blood group system (Hellberg Å, Westman JS, Thuresson B, Olsson ML. P1PK: the blood group system that changed its name and expanded. Immunohematology 2013;29:25-33) provides recent findings concerning the P1PK blood group system that have both challenged and confirmed old theories. The glycosphingolipids can no longer be considered the sole carriers of the antigens in this system because the P1 antigen has been detected on human red blood cell glycoproteins. New indications suggest that P1Pk synthase activity truly depends on the DXD motif, and the genetic background and molecular mechanism behind the common P1 and P2 phenotypes were found to depend on transcriptional regulation. Transcription factors bind the P1 allele selectively to a motif around rs5751348 in a regulatory region of A4GALT, which enhances transcription of the gene. Nonetheless, unexplained differences in antigen expression between individuals remain.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunohematology
volume
36
issue
3
pages
5 pages
publisher
American Red Cross
external identifiers
  • pmid:33112634
  • scopus:85094852415
ISSN
0894-203X
language
English
LU publication?
yes
id
3408a878-dc45-49c3-a53b-124a9faf674d
date added to LUP
2020-11-17 11:25:14
date last changed
2024-05-15 22:15:16
@article{3408a878-dc45-49c3-a53b-124a9faf674d,
  abstract     = {{<p>CONCLUSIONS: This update on the P1PK blood group system (Hellberg Å, Westman JS, Thuresson B, Olsson ML. P1PK: the blood group system that changed its name and expanded. Immunohematology 2013;29:25-33) provides recent findings concerning the P1PK blood group system that have both challenged and confirmed old theories. The glycosphingolipids can no longer be considered the sole carriers of the antigens in this system because the P1 antigen has been detected on human red blood cell glycoproteins. New indications suggest that P1Pk synthase activity truly depends on the DXD motif, and the genetic background and molecular mechanism behind the common P1 and P2 phenotypes were found to depend on transcriptional regulation. Transcription factors bind the P1 allele selectively to a motif around rs5751348 in a regulatory region of A4GALT, which enhances transcription of the gene. Nonetheless, unexplained differences in antigen expression between individuals remain.</p>}},
  author       = {{Stenfelt, Linn and Hellberg, Åsa and Westman, Julia S. and Olsson, Martin L.}},
  issn         = {{0894-203X}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{99--103}},
  publisher    = {{American Red Cross}},
  series       = {{Immunohematology}},
  title        = {{The P1PK blood group system : revisited and resolved}},
  volume       = {{36}},
  year         = {{2020}},
}