Advanced

Dual versus triple therapy in eradication of Helicobacter pylori

Öhlin, Bertil LU ; Cederberg, A; Kjellin, T; Kullman, E; Melen, K; Staël von Holstein, Christer LU and Thoring, M (2002) In Hepato-Gastroenterology 49(43). p.172-175
Abstract
Background/Aims: Duodenal ulcers should be treated by eradication of Helicobacter pylori. This study compared the efficacy of a proton pump inhibitor together with one or two antibiotics in eradication therapy, Methodology: 177 patients who were H. pylori positive were randomized to receive 14 days of either: lansoprazole 30mg bd and amoxicillin 1g bd (LA), omeprazole 20mg bd and amoxicillin 1g bd (OA) or lansoprazole 30mg bd, amoxicillin 1g bd and clarithromycin 500mg bd (LAC). The efficacy was assessed at four weeks and at six months after the end of treatment. Biopsies were taken for culture and bacterial sensitivity testing at inclusion and at four weeks after the end of treatment. Results: 149 patients were evaluated for efficacy. The... (More)
Background/Aims: Duodenal ulcers should be treated by eradication of Helicobacter pylori. This study compared the efficacy of a proton pump inhibitor together with one or two antibiotics in eradication therapy, Methodology: 177 patients who were H. pylori positive were randomized to receive 14 days of either: lansoprazole 30mg bd and amoxicillin 1g bd (LA), omeprazole 20mg bd and amoxicillin 1g bd (OA) or lansoprazole 30mg bd, amoxicillin 1g bd and clarithromycin 500mg bd (LAC). The efficacy was assessed at four weeks and at six months after the end of treatment. Biopsies were taken for culture and bacterial sensitivity testing at inclusion and at four weeks after the end of treatment. Results: 149 patients were evaluated for efficacy. The eradication rate was significantly higher in LAC (96%) compared to LA (51%) and OA (64%) treatments (P<0.001). At baseline 17%, 21% and 19% of the patients in the LA, OA and LAC groups, respectively, were resistant to metronidazole and only one patient was resistant to clarithromycin. Post-treatment, four patients had acquired metronidazole resistance. Conclusions: LAC is more effective than LA and CA for eradication of H. pylori in duodenal ulcer disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
triple therapy, duodenal ulcer, H. pylori infection, eradication therapy
in
Hepato-Gastroenterology
volume
49
issue
43
pages
172 - 175
publisher
Georg Thieme Verlag
external identifiers
  • wos:000174721200035
  • scopus:0036220017
ISSN
0172-6390
language
English
LU publication?
yes
id
88b2f892-d50d-495c-869a-2ee2996bc76d (old id 341133)
date added to LUP
2007-11-02 13:47:10
date last changed
2017-01-01 06:56:57
@article{88b2f892-d50d-495c-869a-2ee2996bc76d,
  abstract     = {Background/Aims: Duodenal ulcers should be treated by eradication of Helicobacter pylori. This study compared the efficacy of a proton pump inhibitor together with one or two antibiotics in eradication therapy, Methodology: 177 patients who were H. pylori positive were randomized to receive 14 days of either: lansoprazole 30mg bd and amoxicillin 1g bd (LA), omeprazole 20mg bd and amoxicillin 1g bd (OA) or lansoprazole 30mg bd, amoxicillin 1g bd and clarithromycin 500mg bd (LAC). The efficacy was assessed at four weeks and at six months after the end of treatment. Biopsies were taken for culture and bacterial sensitivity testing at inclusion and at four weeks after the end of treatment. Results: 149 patients were evaluated for efficacy. The eradication rate was significantly higher in LAC (96%) compared to LA (51%) and OA (64%) treatments (P&lt;0.001). At baseline 17%, 21% and 19% of the patients in the LA, OA and LAC groups, respectively, were resistant to metronidazole and only one patient was resistant to clarithromycin. Post-treatment, four patients had acquired metronidazole resistance. Conclusions: LAC is more effective than LA and CA for eradication of H. pylori in duodenal ulcer disease.},
  author       = {Öhlin, Bertil and Cederberg, A and Kjellin, T and Kullman, E and Melen, K and Staël von Holstein, Christer and Thoring, M},
  issn         = {0172-6390},
  keyword      = {triple therapy,duodenal ulcer,H. pylori infection,eradication therapy},
  language     = {eng},
  number       = {43},
  pages        = {172--175},
  publisher    = {Georg Thieme Verlag},
  series       = {Hepato-Gastroenterology},
  title        = {Dual versus triple therapy in eradication of Helicobacter pylori},
  volume       = {49},
  year         = {2002},
}