Advanced

Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged men

Skoog, T; Dichtl, W; Boquist, S; Skoglund-Andersson, C; Karpe, F; Tang, R; Bond, MG; de Faire, U; Johansson, Jenny G LU and Eriksson, P, et al. (2002) In European Heart Journal 23(5). p.376-383
Abstract
Aims Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultrasound examination in a population-based cohort of 96 healthy 50-year-old men. Methods and Results TNF-alpha and cellular adhesion molecules were measured with enzyme-linked immunosorbent assays. Plasma TNF-alpha concentration was associated with systolic and diastolic blood pressure, degrees of alimentary lipaemia, plasma very low density... (More)
Aims Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultrasound examination in a population-based cohort of 96 healthy 50-year-old men. Methods and Results TNF-alpha and cellular adhesion molecules were measured with enzyme-linked immunosorbent assays. Plasma TNF-alpha concentration was associated with systolic and diastolic blood pressure, degrees of alimentary lipaemia, plasma very low density lipoprotein triglyceride, low density lipoprotein (LDL) cholesterol concentrations and peak LDL particle size. Two indices of insulin resistance as well as all soluble cellular adhesion molecules correlated positively with TNF-alpha. The plasma TNF-alpha concentration was associated with common carotid intima-media thickness in univariate analysis. In contrast, soluble E-selectin and postprandial triglycerides, but not TNF-alpha, were independent determinants of common carotid intima-media thickness. Conclusion The plasma TNF-alpha concentration is associated with degrees of early atherosclerosis and correlates with metabolic and cellular perturbations that are considered important for the vascular process. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
common carotid intima-media thickness, atherosclerosis, tumour necrosis, intercellular adhesion molecule-1, factor-alpha, vascular adhesion, molecule-1, E-selectin
in
European Heart Journal
volume
23
issue
5
pages
376 - 383
publisher
Oxford University Press
external identifiers
  • pmid:11846495
  • wos:000174107100008
  • scopus:0036522142
ISSN
1522-9645
DOI
10.1053/euhj.2001.2805
language
English
LU publication?
yes
id
f211d3d6-f16f-4b77-b940-a0b8be769b36 (old id 342940)
date added to LUP
2007-11-09 11:48:20
date last changed
2017-12-10 04:27:06
@article{f211d3d6-f16f-4b77-b940-a0b8be769b36,
  abstract     = {Aims Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultrasound examination in a population-based cohort of 96 healthy 50-year-old men. Methods and Results TNF-alpha and cellular adhesion molecules were measured with enzyme-linked immunosorbent assays. Plasma TNF-alpha concentration was associated with systolic and diastolic blood pressure, degrees of alimentary lipaemia, plasma very low density lipoprotein triglyceride, low density lipoprotein (LDL) cholesterol concentrations and peak LDL particle size. Two indices of insulin resistance as well as all soluble cellular adhesion molecules correlated positively with TNF-alpha. The plasma TNF-alpha concentration was associated with common carotid intima-media thickness in univariate analysis. In contrast, soluble E-selectin and postprandial triglycerides, but not TNF-alpha, were independent determinants of common carotid intima-media thickness. Conclusion The plasma TNF-alpha concentration is associated with degrees of early atherosclerosis and correlates with metabolic and cellular perturbations that are considered important for the vascular process.},
  author       = {Skoog, T and Dichtl, W and Boquist, S and Skoglund-Andersson, C and Karpe, F and Tang, R and Bond, MG and de Faire, U and Johansson, Jenny G and Eriksson, P and Hamsten, A},
  issn         = {1522-9645},
  keyword      = {common carotid intima-media thickness,atherosclerosis,tumour necrosis,intercellular adhesion molecule-1,factor-alpha,vascular adhesion,molecule-1,E-selectin},
  language     = {eng},
  number       = {5},
  pages        = {376--383},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal},
  title        = {Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged men},
  url          = {http://dx.doi.org/10.1053/euhj.2001.2805},
  volume       = {23},
  year         = {2002},
}