RIFM fragrance ingredient safety assessment, 2,2-dimethyl-3-methyl-3-butenyl propanoate, CAS Registry Number 104468-21-5
(2020) In Food and Chemical Toxicology 144.- Abstract
Summary: The existing information supports the use of this material as described in this safety assessment. 2,2-Dimethyl-3-methyl-3-butenyl propanoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog rhodinyl formate (CAS # 141-09-3) show that 2,2-dimethyl-3-methyl-3-butenyl propanoate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to 2,2-dimethyl-3-methyl-3-butenyl propanoate is below the TTC (0.03... (More)
Summary: The existing information supports the use of this material as described in this safety assessment. 2,2-Dimethyl-3-methyl-3-butenyl propanoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog rhodinyl formate (CAS # 141-09-3) show that 2,2-dimethyl-3-methyl-3-butenyl propanoate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to 2,2-dimethyl-3-methyl-3-butenyl propanoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 2,2-dimethyl-3-methyl-3-butenyl propanoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 2,2-dimethyl-3-methyl-3-butenyl propanoate was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
(Less)
- author
- publishing date
- 2020-07-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- And reproductive toxicity, Developmental, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
- in
- Food and Chemical Toxicology
- volume
- 144
- article number
- 111489
- publisher
- Elsevier
- external identifiers
-
- pmid:32640356
- scopus:85087987099
- ISSN
- 0278-6915
- DOI
- 10.1016/j.fct.2020.111489
- language
- English
- LU publication?
- no
- id
- 3433d0ce-2794-481b-bb90-9a63a51ca141
- date added to LUP
- 2020-07-30 13:44:00
- date last changed
- 2024-04-03 12:27:32
@article{3433d0ce-2794-481b-bb90-9a63a51ca141,
abstract = {{<p>Summary: The existing information supports the use of this material as described in this safety assessment. 2,2-Dimethyl-3-methyl-3-butenyl propanoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog rhodinyl formate (CAS # 141-09-3) show that 2,2-dimethyl-3-methyl-3-butenyl propanoate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to 2,2-dimethyl-3-methyl-3-butenyl propanoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm<sup>2</sup>); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 2,2-dimethyl-3-methyl-3-butenyl propanoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 2,2-dimethyl-3-methyl-3-butenyl propanoate was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.</p>}},
author = {{Api, A. M. and Belsito, D. and Biserta, S. and Botelho, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Cancellieri, M. A. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Fryer, A. D. and Gadhia, S. and Jones, L. and Joshi, K. and Lapczynski, A. and Lavelle, M. and Liebler, D. C. and Na, M. and O'Brien, D. and Patel, A. and Penning, T. M. and Ritacco, G. and Rodriguez-Ropero, F. and Romine, J. and Sadekar, N. and Salvito, D. and Schultz, T. W. and Siddiqi, F. and Sipes, I. G. and Sullivan, G. and Thakkar, Y. and Tokura, Y. and Tsang, S.}},
issn = {{0278-6915}},
keywords = {{And reproductive toxicity; Developmental; Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Skin sensitization}},
language = {{eng}},
month = {{07}},
publisher = {{Elsevier}},
series = {{Food and Chemical Toxicology}},
title = {{RIFM fragrance ingredient safety assessment, 2,2-dimethyl-3-methyl-3-butenyl propanoate, CAS Registry Number 104468-21-5}},
url = {{http://dx.doi.org/10.1016/j.fct.2020.111489}},
doi = {{10.1016/j.fct.2020.111489}},
volume = {{144}},
year = {{2020}},
}