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Parathyroid gland volume increases with postmaturational aging in the rat

Halloran, B; Udén, Per LU ; Duh, QY; Kikuchi, S; Wieder, T; Cao, J and Clark, O (2002) In American Journal of Physiology: Endocrinology and Metabolism 282(3). p.557-563
Abstract
To examine the pathophysiology of the age-related rise in the plasma concentration of parathyroid hormone (PTH), we studied the relationships among plasma immunoreactive PTH (iPTH), parathyroid gland volume, parathyroid cell proliferation rate, renal function, and blood Ca2+ in male Fischer 344 rats aged 6-28 mo. Plasma iPTH increased 2.5-fold between 6 and 28 mo and correlated with parathyroid gland volume (r=0.87). Gland volume began to increase as early as 6-12 mo of age and by 28 mo was threefold greater than at 6 mo. Gland expansion was a consequence of hyperplasia stimulated in part by an increase in cell proliferative activity late in life. Blood Ca2+ and plasma inorganic phosphorus did not change significantly with age. Glomerular... (More)
To examine the pathophysiology of the age-related rise in the plasma concentration of parathyroid hormone (PTH), we studied the relationships among plasma immunoreactive PTH (iPTH), parathyroid gland volume, parathyroid cell proliferation rate, renal function, and blood Ca2+ in male Fischer 344 rats aged 6-28 mo. Plasma iPTH increased 2.5-fold between 6 and 28 mo and correlated with parathyroid gland volume (r=0.87). Gland volume began to increase as early as 6-12 mo of age and by 28 mo was threefold greater than at 6 mo. Gland expansion was a consequence of hyperplasia stimulated in part by an increase in cell proliferative activity late in life. Blood Ca2+ and plasma inorganic phosphorus did not change significantly with age. Glomerular filtration rate decreased with age but only after the age of 24 mo. Unlike what has been observed in the human, these data suggest that the age-related increase in plasma iPTH in the rat is linked to parathyroid gland hyperplasia and that early gland growth does not appear to be associated with hypocalcemia or renal insufficiency, but rather to developmentally related metabolic changes. Later in life (>24 mo), the increase in parathyroid cell proliferation rate, further hyperplastic expansion of the gland, and increase in iPTH secretion appear to be associated with renal insufficiency. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glomerular filtration rate, parathyroid hormone, renal function
in
American Journal of Physiology: Endocrinology and Metabolism
volume
282
issue
3
pages
557 - 563
publisher
American Physiological Society
external identifiers
  • pmid:11832357
  • wos:000173832200008
  • scopus:0036084731
ISSN
1522-1555
DOI
10.1152/ajpendo.00261.2001
language
English
LU publication?
yes
id
368429ad-296e-4338-82c7-da390e40abf5 (old id 343587)
date added to LUP
2007-08-23 10:20:49
date last changed
2017-01-01 06:39:50
@article{368429ad-296e-4338-82c7-da390e40abf5,
  abstract     = {To examine the pathophysiology of the age-related rise in the plasma concentration of parathyroid hormone (PTH), we studied the relationships among plasma immunoreactive PTH (iPTH), parathyroid gland volume, parathyroid cell proliferation rate, renal function, and blood Ca2+ in male Fischer 344 rats aged 6-28 mo. Plasma iPTH increased 2.5-fold between 6 and 28 mo and correlated with parathyroid gland volume (r=0.87). Gland volume began to increase as early as 6-12 mo of age and by 28 mo was threefold greater than at 6 mo. Gland expansion was a consequence of hyperplasia stimulated in part by an increase in cell proliferative activity late in life. Blood Ca2+ and plasma inorganic phosphorus did not change significantly with age. Glomerular filtration rate decreased with age but only after the age of 24 mo. Unlike what has been observed in the human, these data suggest that the age-related increase in plasma iPTH in the rat is linked to parathyroid gland hyperplasia and that early gland growth does not appear to be associated with hypocalcemia or renal insufficiency, but rather to developmentally related metabolic changes. Later in life (>24 mo), the increase in parathyroid cell proliferation rate, further hyperplastic expansion of the gland, and increase in iPTH secretion appear to be associated with renal insufficiency.},
  author       = {Halloran, B and Udén, Per and Duh, QY and Kikuchi, S and Wieder, T and Cao, J and Clark, O},
  issn         = {1522-1555},
  keyword      = {glomerular filtration rate,parathyroid hormone,renal function},
  language     = {eng},
  number       = {3},
  pages        = {557--563},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Endocrinology and Metabolism},
  title        = {Parathyroid gland volume increases with postmaturational aging in the rat},
  url          = {http://dx.doi.org/10.1152/ajpendo.00261.2001},
  volume       = {282},
  year         = {2002},
}