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What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?

Dunning, Christopher LU ; George, Sonia LU and Brundin, Patrik LU (2013) In Prion 7(1). p.92-97
Abstract
α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease. Misfolded α-synuclein has also been shown to spread from cell-to-cell and, in a prion-like fashion, trigger aggregation of α-synuclein in the recipient cell. In this mini-review we explore the evidence that misfolded α-synuclein underlies the spread of pathology in Parkinson disease and discuss why it should be considered a prion-like protein.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
protein misfolding, cell-to-cell transfer, Parkinson disease, alpha-synuclein, prion-like
in
Prion
volume
7
issue
1
pages
92 - 97
publisher
Landes Bioscience
external identifiers
  • wos:000315034500014
  • pmid:23360753
  • scopus:84874594129
ISSN
1933-6896
DOI
10.4161/pri.23806
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
f4cf2f91-5d3a-45d2-a5b5-dd28b88aa78a (old id 3438176)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23360753?dopt=Abstract
date added to LUP
2016-04-01 10:31:59
date last changed
2022-04-20 03:07:35
@article{f4cf2f91-5d3a-45d2-a5b5-dd28b88aa78a,
  abstract     = {{α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease. Misfolded α-synuclein has also been shown to spread from cell-to-cell and, in a prion-like fashion, trigger aggregation of α-synuclein in the recipient cell. In this mini-review we explore the evidence that misfolded α-synuclein underlies the spread of pathology in Parkinson disease and discuss why it should be considered a prion-like protein.}},
  author       = {{Dunning, Christopher and George, Sonia and Brundin, Patrik}},
  issn         = {{1933-6896}},
  keywords     = {{protein misfolding; cell-to-cell transfer; Parkinson disease; alpha-synuclein; prion-like}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{92--97}},
  publisher    = {{Landes Bioscience}},
  series       = {{Prion}},
  title        = {{What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?}},
  url          = {{http://dx.doi.org/10.4161/pri.23806}},
  doi          = {{10.4161/pri.23806}},
  volume       = {{7}},
  year         = {{2013}},
}