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Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment.

Svensson, Katrin LU and Belting, Mattias LU (2013) In Biochemical Society Transactions 41(1). p.273-276
Abstract
Over the last few decades, extensive studies by several groups have introduced the concept of cell-derived secreted extracellular membrane vesicles as carriers of complex molecular information. Owing to their pleiotropic biological effects and involvement in a wide variety of biological processes, extracellular membrane vesicles have been implicated in physiological as well as pathological events, including tumour development and metastasis. In the present review, we discuss the role of secreted membrane vesicles in intercellular communication with a focus on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation... (More)
Over the last few decades, extensive studies by several groups have introduced the concept of cell-derived secreted extracellular membrane vesicles as carriers of complex molecular information. Owing to their pleiotropic biological effects and involvement in a wide variety of biological processes, extracellular membrane vesicles have been implicated in physiological as well as pathological events, including tumour development and metastasis. In the present review, we discuss the role of secreted membrane vesicles in intercellular communication with a focus on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation activation and angiogenesis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical Society Transactions
volume
41
issue
1
pages
273 - 276
publisher
Biochemical Society
external identifiers
  • wos:000314222900045
  • pmid:23356296
  • scopus:84873150410
ISSN
0300-5127
DOI
10.1042/BST20120248
language
English
LU publication?
yes
id
96707640-b7a1-432f-8181-f0302f947be6 (old id 3438216)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23356296?dopt=Abstract
date added to LUP
2013-02-04 17:59:22
date last changed
2018-05-29 11:31:19
@article{96707640-b7a1-432f-8181-f0302f947be6,
  abstract     = {Over the last few decades, extensive studies by several groups have introduced the concept of cell-derived secreted extracellular membrane vesicles as carriers of complex molecular information. Owing to their pleiotropic biological effects and involvement in a wide variety of biological processes, extracellular membrane vesicles have been implicated in physiological as well as pathological events, including tumour development and metastasis. In the present review, we discuss the role of secreted membrane vesicles in intercellular communication with a focus on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation activation and angiogenesis.},
  author       = {Svensson, Katrin and Belting, Mattias},
  issn         = {0300-5127},
  language     = {eng},
  number       = {1},
  pages        = {273--276},
  publisher    = {Biochemical Society},
  series       = {Biochemical Society Transactions},
  title        = {Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment.},
  url          = {http://dx.doi.org/10.1042/BST20120248},
  volume       = {41},
  year         = {2013},
}