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Transcriptional profiling of human dendritic cell populations and models - unique profiles of in vitro dendritic cells and implications on functionality and applicability.

Lundberg, Kristina LU ; Albrekt, Ann-Sofie LU ; Nelissen, Inge ; Santegoets, Saskia ; de Gruijl, Tanja D ; Gibbs, Sue and Lindstedt, Malin LU (2013) In PLoS ONE 8(1).
Abstract
Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to their scarcity and therefore DC models are commonly employed in DC-based immunotherapy strategies and in vitro tests assessing DC function. However, the interrelationship between the individual in vitro DC models and their relative resemblance to specific primary DC populations remain elusive.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
8
issue
1
article number
e52875
publisher
Public Library of Science
external identifiers
  • pmid:23341914
  • wos:000314759400026
  • scopus:84872282547
  • pmid:23341914
ISSN
1932-6203
DOI
10.1371/journal.pone.0052875
language
English
LU publication?
yes
id
2296a8f4-10e4-47b4-85e6-aabfa19c48c1 (old id 3438483)
date added to LUP
2016-04-01 14:17:21
date last changed
2020-09-30 03:22:06
@article{2296a8f4-10e4-47b4-85e6-aabfa19c48c1,
  abstract     = {Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to their scarcity and therefore DC models are commonly employed in DC-based immunotherapy strategies and in vitro tests assessing DC function. However, the interrelationship between the individual in vitro DC models and their relative resemblance to specific primary DC populations remain elusive.},
  author       = {Lundberg, Kristina and Albrekt, Ann-Sofie and Nelissen, Inge and Santegoets, Saskia and de Gruijl, Tanja D and Gibbs, Sue and Lindstedt, Malin},
  issn         = {1932-6203},
  language     = {eng},
  number       = {1},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Transcriptional profiling of human dendritic cell populations and models - unique profiles of in vitro dendritic cells and implications on functionality and applicability.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0052875},
  doi          = {10.1371/journal.pone.0052875},
  volume       = {8},
  year         = {2013},
}