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Urine D-arabinitol/L-arabinitol ratio in diagnosing Candida infection in patients with haematological malignancy and HIV infection

Eisen, DP; Bartley, PB; Hope, W; Sigmundsdottir, Gudrun LU ; Pehrson, Christina LU ; Larsson, Lennart LU and Christensson, Bertil LU (2002) In Diagnostic Microbiology and Infectious Disease 42(1). p.39-42
Abstract
Adult patients with hematologic malignancies along with HIV infected patients were prospectively studied to determine the performance of urine D-arabinitol/L-arabinitol (DA/LA) ratio in diagnosing invasive candidiasis. Ten evaluable febrile neutropenic patients had proven invasive candidiasis and elevated DA/LA ratios were found in 5. Invasive candidiasis with normal DA/LA ratios was most frequently due to Candida krusei infection. This Candida species is a non-producer of arabinitol. Only 4 of 81 febrile neutropenic patients given either antifungal prophylaxis or empiric antifungal treatment had elevated DA/LA ratios. Only 1 of 15 HIV positive patients with either oropharyngeal or esophageal candidiasis had elevated DA/LA ratios.... (More)
Adult patients with hematologic malignancies along with HIV infected patients were prospectively studied to determine the performance of urine D-arabinitol/L-arabinitol (DA/LA) ratio in diagnosing invasive candidiasis. Ten evaluable febrile neutropenic patients had proven invasive candidiasis and elevated DA/LA ratios were found in 5. Invasive candidiasis with normal DA/LA ratios was most frequently due to Candida krusei infection. This Candida species is a non-producer of arabinitol. Only 4 of 81 febrile neutropenic patients given either antifungal prophylaxis or empiric antifungal treatment had elevated DA/LA ratios. Only 1 of 15 HIV positive patients with either oropharyngeal or esophageal candidiasis had elevated DA/LA ratios. Widespread use of fluconazole prophylaxis in bone marrow transplantation patients at the study hospital has led to an increased prevalence of C. krusei infection. This is the likely reason for the low sensitivity of the test in proven and suspected invasive Candida infections reported here. (C) 2002 Elsevier Science Inc. All rights reserved. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Diagnostic Microbiology and Infectious Disease
volume
42
issue
1
pages
39 - 42
publisher
Elsevier
external identifiers
  • wos:000173694900007
  • pmid:11821170
  • scopus:0036164573
ISSN
1879-0070
DOI
10.1016/S0732-8893(01)00310-8
language
English
LU publication?
yes
id
b58533ce-1f2e-40cb-b67d-897f78396bdb (old id 343925)
date added to LUP
2007-08-16 11:33:16
date last changed
2017-01-01 04:40:34
@article{b58533ce-1f2e-40cb-b67d-897f78396bdb,
  abstract     = {Adult patients with hematologic malignancies along with HIV infected patients were prospectively studied to determine the performance of urine D-arabinitol/L-arabinitol (DA/LA) ratio in diagnosing invasive candidiasis. Ten evaluable febrile neutropenic patients had proven invasive candidiasis and elevated DA/LA ratios were found in 5. Invasive candidiasis with normal DA/LA ratios was most frequently due to Candida krusei infection. This Candida species is a non-producer of arabinitol. Only 4 of 81 febrile neutropenic patients given either antifungal prophylaxis or empiric antifungal treatment had elevated DA/LA ratios. Only 1 of 15 HIV positive patients with either oropharyngeal or esophageal candidiasis had elevated DA/LA ratios. Widespread use of fluconazole prophylaxis in bone marrow transplantation patients at the study hospital has led to an increased prevalence of C. krusei infection. This is the likely reason for the low sensitivity of the test in proven and suspected invasive Candida infections reported here. (C) 2002 Elsevier Science Inc. All rights reserved.},
  author       = {Eisen, DP and Bartley, PB and Hope, W and Sigmundsdottir, Gudrun and Pehrson, Christina and Larsson, Lennart and Christensson, Bertil},
  issn         = {1879-0070},
  language     = {eng},
  number       = {1},
  pages        = {39--42},
  publisher    = {Elsevier},
  series       = {Diagnostic Microbiology and Infectious Disease},
  title        = {Urine D-arabinitol/L-arabinitol ratio in diagnosing Candida infection in patients with haematological malignancy and HIV infection},
  url          = {http://dx.doi.org/10.1016/S0732-8893(01)00310-8},
  volume       = {42},
  year         = {2002},
}