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Quality of life in patients with chronic alveolar hypoventilation

Dellborg, C ; Olofson, J ; Midgren, Bengt LU ; Caro, O ; Skoogh, BE and Sullivan, M (2002) In European Respiratory Journal 19(1). p.113-120
Abstract
Measurements of health-related quality of life (HRQL) have not been reported in patients with chronic alveolar hypoventilation (CAH) before starting home mechanical ventilation. The purpose of this study was to investigate quality of life in a population of such patients. Forty-four consecutive patients with CAH due to previous polio, scoliosis, healed pulmonary tuberculosis or neuromuscular disease answered a battery of condition specific and generic (Sickness Impact Profile, Hospital Anxiety and Depression scale, Mood Adjective Check List) self-report questionnaires. Spirometry, arterial blood gases and overnight oxygen saturation were measured. Patients with untreated CAH had significantly impaired HRQL compared to historical data from... (More)
Measurements of health-related quality of life (HRQL) have not been reported in patients with chronic alveolar hypoventilation (CAH) before starting home mechanical ventilation. The purpose of this study was to investigate quality of life in a population of such patients. Forty-four consecutive patients with CAH due to previous polio, scoliosis, healed pulmonary tuberculosis or neuromuscular disease answered a battery of condition specific and generic (Sickness Impact Profile, Hospital Anxiety and Depression scale, Mood Adjective Check List) self-report questionnaires. Spirometry, arterial blood gases and overnight oxygen saturation were measured. Patients with untreated CAH had significantly impaired HRQL compared to historical data from a healthy reference population. Sleep-related problems were frequent. Age, underlying disease, and standard bicarbonate correlated significantly with HRQL measures, albeit with modest levels of explained variance (8-37%). Patients with chronic alveolar hypoventilation due to neuromuscular or restrictive chest wall disorders had severely impaired health-related quality of life. Age, the underlying disease and severity of hypoventilation are each related to the health-related quality of life decrements. Health-related quality of life measurements add important information to traditional clinical observations. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
quality of life, wall disorders, chronic alveolar hypoventilation, neuromuscular and restrictive chest
in
European Respiratory Journal
volume
19
issue
1
pages
113 - 120
publisher
European Respiratory Society
external identifiers
  • wos:000173549500020
  • pmid:11843309
  • scopus:0036153282
ISSN
1399-3003
DOI
10.1183/09031936.02.00211902
language
English
LU publication?
yes
id
df06a7ec-6a6e-4816-b700-b4dc4a567cec (old id 344162)
date added to LUP
2016-04-01 12:25:06
date last changed
2021-01-06 07:26:33
@article{df06a7ec-6a6e-4816-b700-b4dc4a567cec,
  abstract     = {Measurements of health-related quality of life (HRQL) have not been reported in patients with chronic alveolar hypoventilation (CAH) before starting home mechanical ventilation. The purpose of this study was to investigate quality of life in a population of such patients. Forty-four consecutive patients with CAH due to previous polio, scoliosis, healed pulmonary tuberculosis or neuromuscular disease answered a battery of condition specific and generic (Sickness Impact Profile, Hospital Anxiety and Depression scale, Mood Adjective Check List) self-report questionnaires. Spirometry, arterial blood gases and overnight oxygen saturation were measured. Patients with untreated CAH had significantly impaired HRQL compared to historical data from a healthy reference population. Sleep-related problems were frequent. Age, underlying disease, and standard bicarbonate correlated significantly with HRQL measures, albeit with modest levels of explained variance (8-37%). Patients with chronic alveolar hypoventilation due to neuromuscular or restrictive chest wall disorders had severely impaired health-related quality of life. Age, the underlying disease and severity of hypoventilation are each related to the health-related quality of life decrements. Health-related quality of life measurements add important information to traditional clinical observations.},
  author       = {Dellborg, C and Olofson, J and Midgren, Bengt and Caro, O and Skoogh, BE and Sullivan, M},
  issn         = {1399-3003},
  language     = {eng},
  number       = {1},
  pages        = {113--120},
  publisher    = {European Respiratory Society},
  series       = {European Respiratory Journal},
  title        = {Quality of life in patients with chronic alveolar hypoventilation},
  url          = {http://dx.doi.org/10.1183/09031936.02.00211902},
  doi          = {10.1183/09031936.02.00211902},
  volume       = {19},
  year         = {2002},
}