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Putaminal Upregulation of FosB/Delta FosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia

Lindgren, Hanna LU ; Rylander, Daniella LU ; Iderberg, Hanna LU ; Andersson, M.; O'Sullivan, S. S.; Williams, D. R.; Lees, A. J. and Cenci Nilsson, Angela LU (2011) In Journal of Parkinson's Disease 1(4). p.347-357
Abstract
The transcription factor Delta FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson's disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and Delta FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classified as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/Delta FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates.... (More)
The transcription factor Delta FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson's disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and Delta FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classified as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/Delta FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates. In contrast, the number of FosB/Delta FosB-positive cells did not differ significantly among the groups in the caudate, a region primarily involved with the processing of cognitive and limbic-related information. Only sparse FosB/Delta FosB immunoreactivity was found in the in the pallidum externum and internum, and no significant group differences were detected in these nuclei. The putaminal elevation of FosB/Delta FosB-like immunoreactivity in patients who had been affected by L-DOPA-induced dyskinesia is consistent with results from both rat and non-human primate models of this movement disorder. The present findings support the hypothesis of an involvement of Delta FosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Motor complications, immediate-early genes, striatonigral, striatopallidal, medium-spiny neurons, neurodegeneration, dopaminergic, therapies
in
Journal of Parkinson's Disease
volume
1
issue
4
pages
347 - 357
publisher
IOS Press
external identifiers
  • wos:000308484300005
  • scopus:84863229146
ISSN
1877-718X
DOI
10.3233/JPD-2011-11068
language
English
LU publication?
yes
id
16b957ac-c6a7-46d8-95cf-f7003aadb1ed (old id 3470415)
date added to LUP
2013-03-01 07:44:57
date last changed
2017-09-10 03:11:58
@article{16b957ac-c6a7-46d8-95cf-f7003aadb1ed,
  abstract     = {The transcription factor Delta FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson's disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and Delta FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classified as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/Delta FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates. In contrast, the number of FosB/Delta FosB-positive cells did not differ significantly among the groups in the caudate, a region primarily involved with the processing of cognitive and limbic-related information. Only sparse FosB/Delta FosB immunoreactivity was found in the in the pallidum externum and internum, and no significant group differences were detected in these nuclei. The putaminal elevation of FosB/Delta FosB-like immunoreactivity in patients who had been affected by L-DOPA-induced dyskinesia is consistent with results from both rat and non-human primate models of this movement disorder. The present findings support the hypothesis of an involvement of Delta FosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia.},
  author       = {Lindgren, Hanna and Rylander, Daniella and Iderberg, Hanna and Andersson, M. and O'Sullivan, S. S. and Williams, D. R. and Lees, A. J. and Cenci Nilsson, Angela},
  issn         = {1877-718X},
  keyword      = {Motor complications,immediate-early genes,striatonigral,striatopallidal,medium-spiny neurons,neurodegeneration,dopaminergic,therapies},
  language     = {eng},
  number       = {4},
  pages        = {347--357},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Putaminal Upregulation of FosB/Delta FosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia},
  url          = {http://dx.doi.org/10.3233/JPD-2011-11068},
  volume       = {1},
  year         = {2011},
}