Positive allosteric feedback regulation of the stringent response enzyme RelA by its product
Shyp, Viktoriya ; Tankov, Stoyan ; Ermakov, Andrey ; Kudrin, Pavel ; English, Brian P. ; Ehrenberg, Mãns ; Tenson, Tanel ; Elf, Johan and Hauryliuk, Vasili LU
(2012)
In EMBO Reports
13(9).
p.835-839
- Abstract
During the stringent response, Escherichia coli enzyme RelA produces the ppGpp alarmone, which in turn regulates transcription, translation and replication. We show that ppGpp dramatically increases the turnover rate of its own ribosome-dependent synthesis by RelA, resulting in direct positive regulation of an enzyme by its product. Positive allosteric regulation therefore constitutes a new mechanism of enzyme activation. By integrating the output of individual RelA molecules and ppGpp degradation pathways, this regulatory circuit contributes to a fast and coordinated transition to stringency.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/347b9924-716e-42ff-9baf-5976a8736b6c
- author
- Shyp, Viktoriya
; Tankov, Stoyan
; Ermakov, Andrey
; Kudrin, Pavel
; English, Brian P.
; Ehrenberg, Mãns
; Tenson, Tanel
; Elf, Johan
and Hauryliuk, Vasili
LU
- publishing date
- 2012-09
- type
- Contribution to journal
- publication status
- published
- keywords
- alarmone, L11, ppGpp, ribosome, signalling
- in
- EMBO Reports
- volume
- 13
- issue
- 9
- pages
- 835 - 839
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:22814757
- scopus:84865760487
- ISSN
- 1469-221X
- DOI
- 10.1038/embor.2012.106
- language
- English
- LU publication?
- no
- additional info
- Copyright: Copyright 2013 Elsevier B.V., All rights reserved.
- id
- 347b9924-716e-42ff-9baf-5976a8736b6c
- date added to LUP
- 2021-09-24 20:51:17
- date last changed
- 2024-01-05 16:53:51
@article{347b9924-716e-42ff-9baf-5976a8736b6c,
abstract = {{<p>During the stringent response, Escherichia coli enzyme RelA produces the ppGpp alarmone, which in turn regulates transcription, translation and replication. We show that ppGpp dramatically increases the turnover rate of its own ribosome-dependent synthesis by RelA, resulting in direct positive regulation of an enzyme by its product. Positive allosteric regulation therefore constitutes a new mechanism of enzyme activation. By integrating the output of individual RelA molecules and ppGpp degradation pathways, this regulatory circuit contributes to a fast and coordinated transition to stringency.</p>}},
author = {{Shyp, Viktoriya and Tankov, Stoyan and Ermakov, Andrey and Kudrin, Pavel and English, Brian P. and Ehrenberg, Mãns and Tenson, Tanel and Elf, Johan and Hauryliuk, Vasili}},
issn = {{1469-221X}},
keywords = {{alarmone; L11; ppGpp; ribosome; signalling}},
language = {{eng}},
number = {{9}},
pages = {{835--839}},
publisher = {{Nature Publishing Group}},
series = {{EMBO Reports}},
title = {{Positive allosteric feedback regulation of the stringent response enzyme RelA by its product}},
url = {{http://dx.doi.org/10.1038/embor.2012.106}},
doi = {{10.1038/embor.2012.106}},
volume = {{13}},
year = {{2012}},
}