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Molecular subtyping of male breast cancer using alternative definitions and its prognostic impact

Nilsson, Cecilia ; Johansson, Ida LU ; Ahlin, Cecilia ; Thorstenson, Sten ; Amini, Rose-Marie ; Holmqvist, Marit ; Bergkvist, Leif ; Hedenfalk, Ingrid LU and Fjallskog, Marie-Louise (2013) In Acta Oncologica 52(1). p.102-109
Abstract
Background. Male breast cancer (MBC) is an uncommon disease and there is limited information on the prognostic impact of routinely used clinicopathological parameters. Material and methods. In a retrospective setting, we reviewed 197 MBC patients with accessible paraffin-embedded tumor tissue and clinicopathological data. Immunohistochemical (IHC) stainings were performed on tissue microarrays and histological grading on conventional slides. Cox proportional regression models were applied for uni- and multivariate analyses using breast cancer death as the event. Results. Estrogen receptor (ER) and progesterone receptor positivity were demonstrated in 93% and 77% of patients, respectively. Nottingham histologic grade (NHG) III was seen in... (More)
Background. Male breast cancer (MBC) is an uncommon disease and there is limited information on the prognostic impact of routinely used clinicopathological parameters. Material and methods. In a retrospective setting, we reviewed 197 MBC patients with accessible paraffin-embedded tumor tissue and clinicopathological data. Immunohistochemical (IHC) stainings were performed on tissue microarrays and histological grading on conventional slides. Cox proportional regression models were applied for uni- and multivariate analyses using breast cancer death as the event. Results. Estrogen receptor (ER) and progesterone receptor positivity were demonstrated in 93% and 77% of patients, respectively. Nottingham histologic grade (NHG) III was seen in 41% and HER2 positivity in 11%. Classification into molecular subtypes using IHC markers according to three alternative definitions revealed luminal A and luminal B in 81% vs. 11%; 48% vs. 44% and 41% vs. 42% of cases. Two cases of basal-like were identified, but no cases of HER2-like. Factors associated with an increased risk of breast cancer death were node positivity (HR 4.5; 95% CI 1.8-11.1), tumor size >20 mm (HR 3.3; 95% CI 1.4-7.9) and ER negativity (HR 10.9; 95% CI 3.2-37.9). No difference in breast cancer death between the luminal subgroups was demonstrated, regardless of definition. Conclusion. MBC tumors were more often of high grade, whereas HER2 overexpression was as frequent as in FBC. Lymph nodes, tumor size and ER status were independent predictors of breast cancer death. The prognostic impact of molecular subtyping in MBC seems to differ from that previously established in FBC. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
52
issue
1
pages
102 - 109
publisher
Taylor & Francis
external identifiers
  • wos:000312505900013
  • scopus:84871456357
  • pmid:22928693
ISSN
1651-226X
DOI
10.3109/0284186X.2012.711952
language
English
LU publication?
yes
id
d8f9d7ee-d6e1-43d6-8a98-041fdf2802d3 (old id 3480971)
date added to LUP
2016-04-01 14:16:16
date last changed
2020-04-15 02:08:24
@article{d8f9d7ee-d6e1-43d6-8a98-041fdf2802d3,
  abstract     = {Background. Male breast cancer (MBC) is an uncommon disease and there is limited information on the prognostic impact of routinely used clinicopathological parameters. Material and methods. In a retrospective setting, we reviewed 197 MBC patients with accessible paraffin-embedded tumor tissue and clinicopathological data. Immunohistochemical (IHC) stainings were performed on tissue microarrays and histological grading on conventional slides. Cox proportional regression models were applied for uni- and multivariate analyses using breast cancer death as the event. Results. Estrogen receptor (ER) and progesterone receptor positivity were demonstrated in 93% and 77% of patients, respectively. Nottingham histologic grade (NHG) III was seen in 41% and HER2 positivity in 11%. Classification into molecular subtypes using IHC markers according to three alternative definitions revealed luminal A and luminal B in 81% vs. 11%; 48% vs. 44% and 41% vs. 42% of cases. Two cases of basal-like were identified, but no cases of HER2-like. Factors associated with an increased risk of breast cancer death were node positivity (HR 4.5; 95% CI 1.8-11.1), tumor size >20 mm (HR 3.3; 95% CI 1.4-7.9) and ER negativity (HR 10.9; 95% CI 3.2-37.9). No difference in breast cancer death between the luminal subgroups was demonstrated, regardless of definition. Conclusion. MBC tumors were more often of high grade, whereas HER2 overexpression was as frequent as in FBC. Lymph nodes, tumor size and ER status were independent predictors of breast cancer death. The prognostic impact of molecular subtyping in MBC seems to differ from that previously established in FBC.},
  author       = {Nilsson, Cecilia and Johansson, Ida and Ahlin, Cecilia and Thorstenson, Sten and Amini, Rose-Marie and Holmqvist, Marit and Bergkvist, Leif and Hedenfalk, Ingrid and Fjallskog, Marie-Louise},
  issn         = {1651-226X},
  language     = {eng},
  number       = {1},
  pages        = {102--109},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Molecular subtyping of male breast cancer using alternative definitions and its prognostic impact},
  url          = {http://dx.doi.org/10.3109/0284186X.2012.711952},
  doi          = {10.3109/0284186X.2012.711952},
  volume       = {52},
  year         = {2013},
}