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Potentiometric propranolol-selective sensor based on molecularly imprinted polymer

Gurtova, O. ; Ye, Lei LU and Chmilenko, F. (2013) In Analytical and Bioanalytical Chemistry 405(1). p.287-295
Abstract
A novel potentiometric sensor based on molecularly imprinted polymer (MIP) for propranolol, an adrenergic-blocking drug, was designed. The influence of molecularly imprinted polymer particle content and sodium tetraphenylborate additives in polyvinylchloride membrane was shown. The electrodes show near-Nernstian responses down to 10(-4)-10(-5) M propranolol concentration. The potentiometric response of MIP-based sensor for propranolol in mixed nonaqueous medium was shown at first. Sensor selectivity relative to various inorganic cations, atenolol and metoprolol, was reported. Direct potentiometry was used to determine propranolol in aqueous modeling solutions and pharmaceutical preparations with good results.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Molecular imprinted polymer, Propranolol, Potentiometric sensor, Nanoparticles, Anaprilin
in
Analytical and Bioanalytical Chemistry
volume
405
issue
1
pages
287 - 295
publisher
Springer
external identifiers
  • wos:000313064000028
  • scopus:84872290164
  • pmid:23104313
ISSN
1618-2642
DOI
10.1007/s00216-012-6493-6
language
English
LU publication?
yes
id
d6b2b379-1d5a-4e61-86c0-b4ba9bfd3152 (old id 3480990)
date added to LUP
2016-04-01 11:02:16
date last changed
2020-01-12 06:52:07
@article{d6b2b379-1d5a-4e61-86c0-b4ba9bfd3152,
  abstract     = {A novel potentiometric sensor based on molecularly imprinted polymer (MIP) for propranolol, an adrenergic-blocking drug, was designed. The influence of molecularly imprinted polymer particle content and sodium tetraphenylborate additives in polyvinylchloride membrane was shown. The electrodes show near-Nernstian responses down to 10(-4)-10(-5) M propranolol concentration. The potentiometric response of MIP-based sensor for propranolol in mixed nonaqueous medium was shown at first. Sensor selectivity relative to various inorganic cations, atenolol and metoprolol, was reported. Direct potentiometry was used to determine propranolol in aqueous modeling solutions and pharmaceutical preparations with good results.},
  author       = {Gurtova, O. and Ye, Lei and Chmilenko, F.},
  issn         = {1618-2642},
  language     = {eng},
  number       = {1},
  pages        = {287--295},
  publisher    = {Springer},
  series       = {Analytical and Bioanalytical Chemistry},
  title        = {Potentiometric propranolol-selective sensor based on molecularly imprinted polymer},
  url          = {http://dx.doi.org/10.1007/s00216-012-6493-6},
  doi          = {10.1007/s00216-012-6493-6},
  volume       = {405},
  year         = {2013},
}