Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Liquid fiducial marker applicability in proton therapy of locally advanced lung cancer

Scherman Rydhög, Jonas ; Perrin, Rosalind ; Jølck, Rasmus Irming ; Gagnon-Moisan, Francis ; Larsen, Klaus Richter ; Clementsen, Paul ; Riisgaard de Blanck, Steen ; Fredberg Persson, Gitte ; Weber, Damien Charles and Lomax, Tony , et al. (2017) In Radiotherapy and Oncology 122(3). p.393-399
Abstract

Background and purpose We investigated the clinical applicability of a novel liquid fiducial marker (LFM) for image-guided pencil beam scanned (PBS) proton therapy (PBSPT) of locally advanced lung cancer (LALC). Materials and methods The relative proton stopping power (RSP) of the LFM was calculated and measured. Dose perturbations of the LFM and three solid markers, in a phantom, were measured. PBSPT treatment planning on computer tomography scans of five patients with LALC with the LFM implanted was performed with 1–3 fields. Results The RSP was experimentally determined to be 1.164 for the LFM. Phantom measurements revealed a maximum relative deviation in dose of 4.8% for the LFM in the spread-out Bragg Peak, compared to 12–67% for... (More)

Background and purpose We investigated the clinical applicability of a novel liquid fiducial marker (LFM) for image-guided pencil beam scanned (PBS) proton therapy (PBSPT) of locally advanced lung cancer (LALC). Materials and methods The relative proton stopping power (RSP) of the LFM was calculated and measured. Dose perturbations of the LFM and three solid markers, in a phantom, were measured. PBSPT treatment planning on computer tomography scans of five patients with LALC with the LFM implanted was performed with 1–3 fields. Results The RSP was experimentally determined to be 1.164 for the LFM. Phantom measurements revealed a maximum relative deviation in dose of 4.8% for the LFM in the spread-out Bragg Peak, compared to 12–67% for the solid markers. Using the experimentally determined RSP, the maximum proton range error introduced by the LFM is about 1 mm. If the marker was displaced at PBSPT, the maximum dosimetric error was limited to 2 percentage points for 3-field plans. Conclusion The dose perturbations introduced by the LFM were considerably smaller than the solid markers investigated. The RSP of the fiducial marker should be corrected in the treatment planning system to avoid errors. The investigated LFM introduced clinically acceptable dose perturbations for image-guided PBSPT of LALC.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
keywords
Beam perturbation, Liquid fiducial marker, Lung cancer, Proton therapy
in
Radiotherapy and Oncology
volume
122
issue
3
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:28104299
  • scopus:85009343330
ISSN
0167-8140
DOI
10.1016/j.radonc.2016.12.027
language
English
LU publication?
no
id
34b7cf17-9230-4dbd-bdbe-f34105ce5750
date added to LUP
2020-07-28 09:02:32
date last changed
2024-03-05 01:38:45
@article{34b7cf17-9230-4dbd-bdbe-f34105ce5750,
  abstract     = {{<p>Background and purpose We investigated the clinical applicability of a novel liquid fiducial marker (LFM) for image-guided pencil beam scanned (PBS) proton therapy (PBSPT) of locally advanced lung cancer (LALC). Materials and methods The relative proton stopping power (RSP) of the LFM was calculated and measured. Dose perturbations of the LFM and three solid markers, in a phantom, were measured. PBSPT treatment planning on computer tomography scans of five patients with LALC with the LFM implanted was performed with 1–3 fields. Results The RSP was experimentally determined to be 1.164 for the LFM. Phantom measurements revealed a maximum relative deviation in dose of 4.8% for the LFM in the spread-out Bragg Peak, compared to 12–67% for the solid markers. Using the experimentally determined RSP, the maximum proton range error introduced by the LFM is about 1 mm. If the marker was displaced at PBSPT, the maximum dosimetric error was limited to 2 percentage points for 3-field plans. Conclusion The dose perturbations introduced by the LFM were considerably smaller than the solid markers investigated. The RSP of the fiducial marker should be corrected in the treatment planning system to avoid errors. The investigated LFM introduced clinically acceptable dose perturbations for image-guided PBSPT of LALC.</p>}},
  author       = {{Scherman Rydhög, Jonas and Perrin, Rosalind and Jølck, Rasmus Irming and Gagnon-Moisan, Francis and Larsen, Klaus Richter and Clementsen, Paul and Riisgaard de Blanck, Steen and Fredberg Persson, Gitte and Weber, Damien Charles and Lomax, Tony and Andresen, Thomas Lars and Munck af Rosenschold, Per}},
  issn         = {{0167-8140}},
  keywords     = {{Beam perturbation; Liquid fiducial marker; Lung cancer; Proton therapy}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{393--399}},
  publisher    = {{Elsevier}},
  series       = {{Radiotherapy and Oncology}},
  title        = {{Liquid fiducial marker applicability in proton therapy of locally advanced lung cancer}},
  url          = {{http://dx.doi.org/10.1016/j.radonc.2016.12.027}},
  doi          = {{10.1016/j.radonc.2016.12.027}},
  volume       = {{122}},
  year         = {{2017}},
}