Cellular and Molecular Interplay in Bone Homeostasis and Healing
(2024) p.3-19- Abstract
Bone is a complex hierarchical structure mainly comprising of a matrix of collagen and hydroxyapatite. The main physiological functions of bone include regulating skeletal remodeling, calcium homeostasis and providing a congenial environment to the bone marrow cells to reside and these physiological processes are intricately regulated by various cell types and biomolecules. During trauma to the skeletal system, an even more complex cascade of cellular and biochemical events occurs. Although bone has a remarkable ability to regenerate without the formation of scar tissue, in certain scenarios, the trauma is significant enough to necessitate surgical interventions and yet 5–10% of fractures fail to unite. Therefore, the goal of this book... (More)
Bone is a complex hierarchical structure mainly comprising of a matrix of collagen and hydroxyapatite. The main physiological functions of bone include regulating skeletal remodeling, calcium homeostasis and providing a congenial environment to the bone marrow cells to reside and these physiological processes are intricately regulated by various cell types and biomolecules. During trauma to the skeletal system, an even more complex cascade of cellular and biochemical events occurs. Although bone has a remarkable ability to regenerate without the formation of scar tissue, in certain scenarios, the trauma is significant enough to necessitate surgical interventions and yet 5–10% of fractures fail to unite. Therefore, the goal of this book chapter is to provide a background of the cellular and molecular interplay that occurs during bone homeostasis as well as when an injury occurs. The chapter aims to provide a deep understanding of different cell types and molecules that are involved in the homeostasis process and also during fracture healing. At the end of the chapter, we describe cell-based strategies that have been employed in fracture healing in the recent past both at preclinical and clinical stages using the “tissue engineering” approach.
(Less)
- author
- Raina, Deepak Bushan LU
- organization
- publishing date
- 2024
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Emerging Materials and Technologies for Bone Repair and Regeneration
- pages
- 17 pages
- publisher
- CRC Press/Balkema
- external identifiers
-
- scopus:85199847333
- ISBN
- 9781032309279
- 9781040088616
- DOI
- 10.1201/9781003307310-2
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2025 selection and editorial matter, Ashok Kumar, Sneha Singh, and Prerna Singh; individual chapters, the contributors.
- id
- 34f662ae-8b84-4ce1-b3b5-3c10817d1fad
- date added to LUP
- 2024-11-11 15:42:01
- date last changed
- 2025-03-04 00:24:29
@inbook{34f662ae-8b84-4ce1-b3b5-3c10817d1fad,
abstract = {{<p>Bone is a complex hierarchical structure mainly comprising of a matrix of collagen and hydroxyapatite. The main physiological functions of bone include regulating skeletal remodeling, calcium homeostasis and providing a congenial environment to the bone marrow cells to reside and these physiological processes are intricately regulated by various cell types and biomolecules. During trauma to the skeletal system, an even more complex cascade of cellular and biochemical events occurs. Although bone has a remarkable ability to regenerate without the formation of scar tissue, in certain scenarios, the trauma is significant enough to necessitate surgical interventions and yet 5–10% of fractures fail to unite. Therefore, the goal of this book chapter is to provide a background of the cellular and molecular interplay that occurs during bone homeostasis as well as when an injury occurs. The chapter aims to provide a deep understanding of different cell types and molecules that are involved in the homeostasis process and also during fracture healing. At the end of the chapter, we describe cell-based strategies that have been employed in fracture healing in the recent past both at preclinical and clinical stages using the “tissue engineering” approach.</p>}},
author = {{Raina, Deepak Bushan}},
booktitle = {{Emerging Materials and Technologies for Bone Repair and Regeneration}},
isbn = {{9781032309279}},
language = {{eng}},
pages = {{3--19}},
publisher = {{CRC Press/Balkema}},
title = {{Cellular and Molecular Interplay in Bone Homeostasis and Healing}},
url = {{http://dx.doi.org/10.1201/9781003307310-2}},
doi = {{10.1201/9781003307310-2}},
year = {{2024}},
}