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Remission maintenance in acute myeloid leukemia: impact of functional histamine H-2 receptors expressed by leukemic cells

Aurelius, Johan; Martner, Anna; Brune, Mats; Palmqvist, Lars; Hansson, Markus LU ; Hellstrand, Kristoffer and Thoren, Fredrik B. (2012) In Haematologica 97(12). p.1904-1908
Abstract
Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial. For this study, treatment efficacy was determined among 145 trial patients with morphological forms of acute myeloid leukemia as defined by the French-American-British classification. Leukemia-free survival was strongly improved in M4/M5 (myelomonocytic/monocytic) leukemia but not in M2 (myeloblastic) leukemia. We also analyzed histamine H-2 receptor expression by leukemic cells recovered from 26 newly diagnosed patients. H-2 receptors were typically absent from M2 cells but frequently expressed by M4/M5 cells. M4/M5 cells, but not M2 cells, produced reactive... (More)
Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial. For this study, treatment efficacy was determined among 145 trial patients with morphological forms of acute myeloid leukemia as defined by the French-American-British classification. Leukemia-free survival was strongly improved in M4/M5 (myelomonocytic/monocytic) leukemia but not in M2 (myeloblastic) leukemia. We also analyzed histamine H-2 receptor expression by leukemic cells recovered from 26 newly diagnosed patients. H-2 receptors were typically absent from M2 cells but frequently expressed by M4/M5 cells. M4/M5 cells, but not M2 cells, produced reactive oxygen species that triggered apoptosis in adjacent natural killer cells. These events were significantly inhibited by histamine dihydrochloride. Our data demonstrate the presence of functional histamine H2 receptors on human AML cells and suggest that expression of these receptors by leukemic cells may impact on the effectiveness of histamine-based immunotherapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute myeloid leukemia, remission maintenance, histamine H-2 receptors
in
Haematologica
volume
97
issue
12
pages
1904 - 1908
publisher
Ferrata Storti Foundation
external identifiers
  • wos:000312804500025
  • scopus:84870471262
ISSN
1592-8721
DOI
10.3324/haematol.2012.066399
language
English
LU publication?
yes
id
730a92ac-8ec0-4727-9062-b4b95aefa8ee (old id 3508052)
date added to LUP
2013-03-01 07:51:44
date last changed
2017-11-05 04:17:31
@article{730a92ac-8ec0-4727-9062-b4b95aefa8ee,
  abstract     = {Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial. For this study, treatment efficacy was determined among 145 trial patients with morphological forms of acute myeloid leukemia as defined by the French-American-British classification. Leukemia-free survival was strongly improved in M4/M5 (myelomonocytic/monocytic) leukemia but not in M2 (myeloblastic) leukemia. We also analyzed histamine H-2 receptor expression by leukemic cells recovered from 26 newly diagnosed patients. H-2 receptors were typically absent from M2 cells but frequently expressed by M4/M5 cells. M4/M5 cells, but not M2 cells, produced reactive oxygen species that triggered apoptosis in adjacent natural killer cells. These events were significantly inhibited by histamine dihydrochloride. Our data demonstrate the presence of functional histamine H2 receptors on human AML cells and suggest that expression of these receptors by leukemic cells may impact on the effectiveness of histamine-based immunotherapy.},
  author       = {Aurelius, Johan and Martner, Anna and Brune, Mats and Palmqvist, Lars and Hansson, Markus and Hellstrand, Kristoffer and Thoren, Fredrik B.},
  issn         = {1592-8721},
  keyword      = {acute myeloid leukemia,remission maintenance,histamine H-2 receptors},
  language     = {eng},
  number       = {12},
  pages        = {1904--1908},
  publisher    = {Ferrata Storti Foundation},
  series       = {Haematologica},
  title        = {Remission maintenance in acute myeloid leukemia: impact of functional histamine H-2 receptors expressed by leukemic cells},
  url          = {http://dx.doi.org/10.3324/haematol.2012.066399},
  volume       = {97},
  year         = {2012},
}