Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
Rafiee, Zeinab LU ; García-Serrano, Alba M. LU and Duarte, João M.N. LU
(2022)
In Nutrients
14(6).
- Abstract
Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and function and constitute risk factors for cognitive impairment. Alterations to taurine homeostasis can impact a number of biological processes, such as osmolarity control, calcium homeostasis, and inhibitory neurotransmission, and have been reported in both metabolic and neurodegenerative disorders. Models of neurodegenerative disorders show reduced brain taurine concentrations. On the other hand, models of insulin-dependent diabetes, insulin resistance, and diet-induced obesity display taurine accumulation in the hippocampus. Given the possible cytoprotective actions of taurine, such cerebral accumulation of taurine might constitute a compensatory... (More)
Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and function and constitute risk factors for cognitive impairment. Alterations to taurine homeostasis can impact a number of biological processes, such as osmolarity control, calcium homeostasis, and inhibitory neurotransmission, and have been reported in both metabolic and neurodegenerative disorders. Models of neurodegenerative disorders show reduced brain taurine concentrations. On the other hand, models of insulin-dependent diabetes, insulin resistance, and diet-induced obesity display taurine accumulation in the hippocampus. Given the possible cytoprotective actions of taurine, such cerebral accumulation of taurine might constitute a compensatory mechanism that attempts to prevent neurodegeneration. The present article provides an overview of brain taurine homeostasis and reviews the mechanisms by which taurine can afford neuroprotection in individuals with obesity and diabetes. We conclude that further research is needed for understanding taurine homeostasis in metabolic disorders with an impact on brain function.
(Less)
- author
- Rafiee, Zeinab
LU
; García-Serrano, Alba M.
LU
and Duarte, João M.N.
LU
- organization
- publishing date
- 2022-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 2-aminoethanesulfonic acid, Brain metabolism, Diabetes, Neurodegeneration, Obesity
- in
- Nutrients
- volume
- 14
- issue
- 6
- article number
- 1292
- publisher
- MDPI AG
- external identifiers
-
- pmid:35334949
- scopus:85126486861
- ISSN
- 2072-6643
- DOI
- 10.3390/nu14061292
- language
- English
- LU publication?
- yes
- id
- 351eedaf-415e-4fd1-815d-9ff25f263f8e
- date added to LUP
- 2022-05-04 09:34:36
- date last changed
- 2024-06-13 12:16:53
@article{351eedaf-415e-4fd1-815d-9ff25f263f8e,
abstract = {{<p>Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and function and constitute risk factors for cognitive impairment. Alterations to taurine homeostasis can impact a number of biological processes, such as osmolarity control, calcium homeostasis, and inhibitory neurotransmission, and have been reported in both metabolic and neurodegenerative disorders. Models of neurodegenerative disorders show reduced brain taurine concentrations. On the other hand, models of insulin-dependent diabetes, insulin resistance, and diet-induced obesity display taurine accumulation in the hippocampus. Given the possible cytoprotective actions of taurine, such cerebral accumulation of taurine might constitute a compensatory mechanism that attempts to prevent neurodegeneration. The present article provides an overview of brain taurine homeostasis and reviews the mechanisms by which taurine can afford neuroprotection in individuals with obesity and diabetes. We conclude that further research is needed for understanding taurine homeostasis in metabolic disorders with an impact on brain function.</p>}},
author = {{Rafiee, Zeinab and García-Serrano, Alba M. and Duarte, João M.N.}},
issn = {{2072-6643}},
keywords = {{2-aminoethanesulfonic acid; Brain metabolism; Diabetes; Neurodegeneration; Obesity}},
language = {{eng}},
month = {{03}},
number = {{6}},
publisher = {{MDPI AG}},
series = {{Nutrients}},
title = {{Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes}},
url = {{http://dx.doi.org/10.3390/nu14061292}},
doi = {{10.3390/nu14061292}},
volume = {{14}},
year = {{2022}},
}