The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes.
Fava, Cristiano LU ; Montagnana, Martina LU ; Danese, Elisa ; Sjögren, Marketa LU ; Almgren, Peter LU ; Guidi, Gian Cesare ; Hedblad, Bo LU ; Engström, Gunnar LU ; Minuz, Pietro and Melander, Olle LU
(2012)
In Prostaglandins & other Lipid Mediators
98(1-2).
p.31-36
- Abstract
- BACKGROUND AND AIM: The genetic basis of Metabolic syndrome (MetS) is largely unknown but a link with salt sensitivity is recognized. The cytochrome P450 isoform 4F2 (CYP4F2) is involved in renal production of 20-hydroxyeicosatethraenoic acid (20-HETE), a natriuretic substance associated with salt sensitivity. The same enzyme is implicated in ω-hydroxylation of very long and medium chain fatty acids in the liver suggesting its possible influence on gluco-metabolic components of MetS. The aim of the present study was to evaluate the effect of CYP4F2 V433M, a functional polymorphism previously associated with hypertension via renal salt reabsorption, on the individual components of MetS and MetS itself.
METHODS: The... (More) - BACKGROUND AND AIM: The genetic basis of Metabolic syndrome (MetS) is largely unknown but a link with salt sensitivity is recognized. The cytochrome P450 isoform 4F2 (CYP4F2) is involved in renal production of 20-hydroxyeicosatethraenoic acid (20-HETE), a natriuretic substance associated with salt sensitivity. The same enzyme is implicated in ω-hydroxylation of very long and medium chain fatty acids in the liver suggesting its possible influence on gluco-metabolic components of MetS. The aim of the present study was to evaluate the effect of CYP4F2 V433M, a functional polymorphism previously associated with hypertension via renal salt reabsorption, on the individual components of MetS and MetS itself.
METHODS: The polymorphism was genotyped in the cardiovascular cohort of the Malmö Diet and Cancer (MDC-CVA) study and successively in the Malmö Preventive Project (MPP) cohort. Different definitions of the MetS were applied.
RESULTS: In the MDC-CVA, male, but not female, CYP4F2 M433 carriers had significantly higher levels of waist, triglycerides, BP and a composite sum of MetS phenotypes (MetS score) beside lower HDL-cholesterol respect to V-homozygotes. MetS, as defined in the ATPIII and the AHA/NHLBI definitions, was more prevalent in M-carriers with respect to V-homozygotes. In the MPP cohort, significant association was detectable only for triglycerides at baseline and for Diastolic BP at reinvestigation in male M-carriers.
CONCLUSION: The initial positive association of the CYP4F2 V433M polymorphism with components of MetS and MetS itself, found in MDC-CVA, was partially denied in another large cohort. The first association either could be due to a false positive result or alternatively, different genetic background or population stratification could have hidden the effect of the polymorphism in the replication cohort. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2519709
- author
- Fava, Cristiano
LU
; Montagnana, Martina
LU
; Danese, Elisa
; Sjögren, Marketa
LU
; Almgren, Peter
LU
; Guidi, Gian Cesare
; Hedblad, Bo
LU
; Engström, Gunnar
LU
; Minuz, Pietro
and Melander, Olle
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Prostaglandins & other Lipid Mediators
- volume
- 98
- issue
- 1-2
- pages
- 31 - 36
- publisher
- Elsevier
- external identifiers
-
- wos:000304733100005
- pmid:22484021
- scopus:84860721139
- pmid:22484021
- ISSN
- 1098-8823
- DOI
- 10.1016/j.prostaglandins.2012.03.001
- language
- English
- LU publication?
- yes
- id
- 3526561a-d202-4858-8ab9-c7236cce4640 (old id 2519709)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22484021?dopt=Abstract
- date added to LUP
- 2016-04-04 09:30:53
- date last changed
- 2024-03-16 10:45:19
@article{3526561a-d202-4858-8ab9-c7236cce4640,
abstract = {{BACKGROUND AND AIM: The genetic basis of Metabolic syndrome (MetS) is largely unknown but a link with salt sensitivity is recognized. The cytochrome P450 isoform 4F2 (CYP4F2) is involved in renal production of 20-hydroxyeicosatethraenoic acid (20-HETE), a natriuretic substance associated with salt sensitivity. The same enzyme is implicated in ω-hydroxylation of very long and medium chain fatty acids in the liver suggesting its possible influence on gluco-metabolic components of MetS. The aim of the present study was to evaluate the effect of CYP4F2 V433M, a functional polymorphism previously associated with hypertension via renal salt reabsorption, on the individual components of MetS and MetS itself. <br/><br>
<br/><br>
METHODS: The polymorphism was genotyped in the cardiovascular cohort of the Malmö Diet and Cancer (MDC-CVA) study and successively in the Malmö Preventive Project (MPP) cohort. Different definitions of the MetS were applied. <br/><br>
<br/><br>
RESULTS: In the MDC-CVA, male, but not female, CYP4F2 M433 carriers had significantly higher levels of waist, triglycerides, BP and a composite sum of MetS phenotypes (MetS score) beside lower HDL-cholesterol respect to V-homozygotes. MetS, as defined in the ATPIII and the AHA/NHLBI definitions, was more prevalent in M-carriers with respect to V-homozygotes. In the MPP cohort, significant association was detectable only for triglycerides at baseline and for Diastolic BP at reinvestigation in male M-carriers. <br/><br>
<br/><br>
CONCLUSION: The initial positive association of the CYP4F2 V433M polymorphism with components of MetS and MetS itself, found in MDC-CVA, was partially denied in another large cohort. The first association either could be due to a false positive result or alternatively, different genetic background or population stratification could have hidden the effect of the polymorphism in the replication cohort.}},
author = {{Fava, Cristiano and Montagnana, Martina and Danese, Elisa and Sjögren, Marketa and Almgren, Peter and Guidi, Gian Cesare and Hedblad, Bo and Engström, Gunnar and Minuz, Pietro and Melander, Olle}},
issn = {{1098-8823}},
language = {{eng}},
number = {{1-2}},
pages = {{31--36}},
publisher = {{Elsevier}},
series = {{Prostaglandins & other Lipid Mediators}},
title = {{The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes.}},
url = {{http://dx.doi.org/10.1016/j.prostaglandins.2012.03.001}},
doi = {{10.1016/j.prostaglandins.2012.03.001}},
volume = {{98}},
year = {{2012}},
}