Advanced

Environmental toxins and Parkinson's disease : what have we learned from pesticide-induced animal models?

Cicchetti, Francesca; Drouin-Ouellet, Janelle LU and Gross, Robert E (2009) In Trends in Pharmacological Sciences 30(9). p.83-475
Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder largely of idiopathic nature with the exceptions of rare familial forms, and is characterized by both motor and non-motor disturbances. Pathologically, most motor features are the result of a dramatic loss of ventral tier mesencephalic dopaminergic neurons and thus dopamine content at their target sites. Although the exact etiology of the disease remains to be elucidated, it is thought to be multifactorial, with a critical role for environmental factors, such as pesticides, that may act on genetically predisposed individuals. Arising from consideration of the potential environmental triggers of PD, in vivo animal models of the disease utilizing these compounds are... (More)

Parkinson's disease (PD) is a common neurodegenerative disorder largely of idiopathic nature with the exceptions of rare familial forms, and is characterized by both motor and non-motor disturbances. Pathologically, most motor features are the result of a dramatic loss of ventral tier mesencephalic dopaminergic neurons and thus dopamine content at their target sites. Although the exact etiology of the disease remains to be elucidated, it is thought to be multifactorial, with a critical role for environmental factors, such as pesticides, that may act on genetically predisposed individuals. Arising from consideration of the potential environmental triggers of PD, in vivo animal models of the disease utilizing these compounds are increasingly reported in the literature. Here, we review recent advances in the predominant models employing the insecticide Rotenone, the herbicide Paraquat and the fungicide Maneb, discuss their scientific merit and evaluate their relevance in the study of PD pathogenesis.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Disease Models, Animal, Environmental Exposure, Humans, Maneb, Paraquat, Parkinson Disease, Secondary, Pesticides, Rotenone, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
in
Trends in Pharmacological Sciences
volume
30
issue
9
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:69549084529
ISSN
0165-6147
DOI
10.1016/j.tips.2009.06.005
language
English
LU publication?
no
id
3527d573-c888-4ecd-a987-292e073c3e75
date added to LUP
2016-11-22 09:06:21
date last changed
2017-10-29 04:54:17
@article{3527d573-c888-4ecd-a987-292e073c3e75,
  abstract     = {<p>Parkinson's disease (PD) is a common neurodegenerative disorder largely of idiopathic nature with the exceptions of rare familial forms, and is characterized by both motor and non-motor disturbances. Pathologically, most motor features are the result of a dramatic loss of ventral tier mesencephalic dopaminergic neurons and thus dopamine content at their target sites. Although the exact etiology of the disease remains to be elucidated, it is thought to be multifactorial, with a critical role for environmental factors, such as pesticides, that may act on genetically predisposed individuals. Arising from consideration of the potential environmental triggers of PD, in vivo animal models of the disease utilizing these compounds are increasingly reported in the literature. Here, we review recent advances in the predominant models employing the insecticide Rotenone, the herbicide Paraquat and the fungicide Maneb, discuss their scientific merit and evaluate their relevance in the study of PD pathogenesis.</p>},
  author       = {Cicchetti, Francesca and Drouin-Ouellet, Janelle and Gross, Robert E},
  issn         = {0165-6147},
  keyword      = {Animals,Disease Models, Animal,Environmental Exposure,Humans,Maneb,Paraquat,Parkinson Disease, Secondary,Pesticides,Rotenone,Journal Article,Research Support, N.I.H., Extramural,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  number       = {9},
  pages        = {83--475},
  publisher    = {Elsevier},
  series       = {Trends in Pharmacological Sciences},
  title        = {Environmental toxins and Parkinson's disease : what have we learned from pesticide-induced animal models?},
  url          = {http://dx.doi.org/10.1016/j.tips.2009.06.005},
  volume       = {30},
  year         = {2009},
}