Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.
(2015) In BMC Neuroscience 16(1).- Abstract
- Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disease characterized by α-synuclein (α-syn) positive oligodendroglial cytoplasmic inclusions. The latter are associated with a neuronal multisystem neurodegeneration targeting central autonomic, olivopontocerebellar and striatonigral pathways, however the underlying mechanisms of neuronal cell death are poorly understood. Previous experiments have shown that oligodendroglial α-syn pathology increases the susceptibility to mitochondrial stress and proteasomal dysfunction leading to enhanced MSA-like neurodegeneration. Here we analyzed whether oligodendroglial α-syn overexpression in a transgenic mouse model of MSA synergistically interacts with focal neuronal... (More)
- Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disease characterized by α-synuclein (α-syn) positive oligodendroglial cytoplasmic inclusions. The latter are associated with a neuronal multisystem neurodegeneration targeting central autonomic, olivopontocerebellar and striatonigral pathways, however the underlying mechanisms of neuronal cell death are poorly understood. Previous experiments have shown that oligodendroglial α-syn pathology increases the susceptibility to mitochondrial stress and proteasomal dysfunction leading to enhanced MSA-like neurodegeneration. Here we analyzed whether oligodendroglial α-syn overexpression in a transgenic mouse model of MSA synergistically interacts with focal neuronal excitotoxic damage generated by a striatal injection of quinolinic acid (QA) to affect the degree of striatal neuronal loss. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8505878
- author
- Kuzdas-Wood, Daniela ; Fellner, Lisa ; Premstaller, Melanie ; Borm, Carlijn ; Bloem, Bastiaan ; Kirik, Deniz LU ; Wenning, Gregor K and Stefanova, Nadia
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Neuroscience
- volume
- 16
- issue
- 1
- article number
- 86
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26627686
- wos:000365855200001
- scopus:84949187635
- ISSN
- 1471-2202
- DOI
- 10.1186/s12868-015-0227-6
- language
- English
- LU publication?
- yes
- id
- 35486abc-ce20-4076-8fc3-3e36f0190ab4 (old id 8505878)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26627686?dopt=Abstract
- date added to LUP
- 2016-04-01 12:54:38
- date last changed
- 2022-04-21 18:38:44
@article{35486abc-ce20-4076-8fc3-3e36f0190ab4,
abstract = {{Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disease characterized by α-synuclein (α-syn) positive oligodendroglial cytoplasmic inclusions. The latter are associated with a neuronal multisystem neurodegeneration targeting central autonomic, olivopontocerebellar and striatonigral pathways, however the underlying mechanisms of neuronal cell death are poorly understood. Previous experiments have shown that oligodendroglial α-syn pathology increases the susceptibility to mitochondrial stress and proteasomal dysfunction leading to enhanced MSA-like neurodegeneration. Here we analyzed whether oligodendroglial α-syn overexpression in a transgenic mouse model of MSA synergistically interacts with focal neuronal excitotoxic damage generated by a striatal injection of quinolinic acid (QA) to affect the degree of striatal neuronal loss.}},
author = {{Kuzdas-Wood, Daniela and Fellner, Lisa and Premstaller, Melanie and Borm, Carlijn and Bloem, Bastiaan and Kirik, Deniz and Wenning, Gregor K and Stefanova, Nadia}},
issn = {{1471-2202}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Neuroscience}},
title = {{Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.}},
url = {{http://dx.doi.org/10.1186/s12868-015-0227-6}},
doi = {{10.1186/s12868-015-0227-6}},
volume = {{16}},
year = {{2015}},
}