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Decreased expression of nemo-like kinase in melanoma is correlated with increased vascularity and metastasis

Yang, Yvying; Zhe, Hong; Massoumi, Ramin LU and Ke, Hengning (2019) In Melanoma Research 29(4). p.376-381
Abstract

Melanoma is a highly metastatic cancer, and its incidence has increased over the past several decades. Angiogenesis is associated with melanoma metastasis and a poor prognosis. Many genetic and epigenetic factors affecting tumour vascularization and metastasis have been investigated, despite the heterogeneity of cancer cells and the complicated mechanisms involved in melanoma. Nemo-like kinase (NLK) is a serine/threonine kinase regulating the transcription factor by negatively regulating Wnt and downstream vascular endothelial growth factor receptor 2 (VEGFR2) signalling. This study aimed to investigate whether NLK expression in melanoma correlates with VEGFR2-related angiogenesis and melanoma metastasis. Immunohistochemistry analysis... (More)

Melanoma is a highly metastatic cancer, and its incidence has increased over the past several decades. Angiogenesis is associated with melanoma metastasis and a poor prognosis. Many genetic and epigenetic factors affecting tumour vascularization and metastasis have been investigated, despite the heterogeneity of cancer cells and the complicated mechanisms involved in melanoma. Nemo-like kinase (NLK) is a serine/threonine kinase regulating the transcription factor by negatively regulating Wnt and downstream vascular endothelial growth factor receptor 2 (VEGFR2) signalling. This study aimed to investigate whether NLK expression in melanoma correlates with VEGFR2-related angiogenesis and melanoma metastasis. Immunohistochemistry analysis using 175 biopsied tissues of melanoma patients showed that NLK is expressed in 73.7% of melanoma tissues, whereas 26.3% of the samples showed absent expression of NLK. In metastatic melanoma, the expression of NLK was significantly lower than that in primary melanoma (P = 0.002). Furthermore, tissues with a lower expression of NLK showed a higher microvessel density as detected by VEGFR2 expression compared with tissues showing higher NLK expression. These data suggest that reduced expression of NLK in melanoma correlates with VEGFR2-related microvessel formation and melanoma metastasis. This study showed that NLK may serve as a novel prognosis marker and revealed new mechanisms in melanoma metastasis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Melanoma Research
volume
29
issue
4
pages
6 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85069155549
ISSN
0960-8931
DOI
10.1097/CMR.0000000000000576
language
English
LU publication?
yes
id
3557cb79-d569-4e71-8ba7-b3718c1a375f
date added to LUP
2019-07-26 09:47:29
date last changed
2019-09-11 04:21:52
@article{3557cb79-d569-4e71-8ba7-b3718c1a375f,
  abstract     = {<p>Melanoma is a highly metastatic cancer, and its incidence has increased over the past several decades. Angiogenesis is associated with melanoma metastasis and a poor prognosis. Many genetic and epigenetic factors affecting tumour vascularization and metastasis have been investigated, despite the heterogeneity of cancer cells and the complicated mechanisms involved in melanoma. Nemo-like kinase (NLK) is a serine/threonine kinase regulating the transcription factor by negatively regulating Wnt and downstream vascular endothelial growth factor receptor 2 (VEGFR2) signalling. This study aimed to investigate whether NLK expression in melanoma correlates with VEGFR2-related angiogenesis and melanoma metastasis. Immunohistochemistry analysis using 175 biopsied tissues of melanoma patients showed that NLK is expressed in 73.7% of melanoma tissues, whereas 26.3% of the samples showed absent expression of NLK. In metastatic melanoma, the expression of NLK was significantly lower than that in primary melanoma (P = 0.002). Furthermore, tissues with a lower expression of NLK showed a higher microvessel density as detected by VEGFR2 expression compared with tissues showing higher NLK expression. These data suggest that reduced expression of NLK in melanoma correlates with VEGFR2-related microvessel formation and melanoma metastasis. This study showed that NLK may serve as a novel prognosis marker and revealed new mechanisms in melanoma metastasis.</p>},
  author       = {Yang, Yvying and Zhe, Hong and Massoumi, Ramin and Ke, Hengning},
  issn         = {0960-8931},
  language     = {eng},
  number       = {4},
  pages        = {376--381},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Melanoma Research},
  title        = {Decreased expression of nemo-like kinase in melanoma is correlated with increased vascularity and metastasis},
  url          = {http://dx.doi.org/10.1097/CMR.0000000000000576},
  volume       = {29},
  year         = {2019},
}