Decreased expression of nemo-like kinase in melanoma is correlated with increased vascularity and metastasis
(2019) In Melanoma Research 29(4). p.376-381- Abstract
Melanoma is a highly metastatic cancer, and its incidence has increased over the past several decades. Angiogenesis is associated with melanoma metastasis and a poor prognosis. Many genetic and epigenetic factors affecting tumour vascularization and metastasis have been investigated, despite the heterogeneity of cancer cells and the complicated mechanisms involved in melanoma. Nemo-like kinase (NLK) is a serine/threonine kinase regulating the transcription factor by negatively regulating Wnt and downstream vascular endothelial growth factor receptor 2 (VEGFR2) signalling. This study aimed to investigate whether NLK expression in melanoma correlates with VEGFR2-related angiogenesis and melanoma metastasis. Immunohistochemistry analysis... (More)
Melanoma is a highly metastatic cancer, and its incidence has increased over the past several decades. Angiogenesis is associated with melanoma metastasis and a poor prognosis. Many genetic and epigenetic factors affecting tumour vascularization and metastasis have been investigated, despite the heterogeneity of cancer cells and the complicated mechanisms involved in melanoma. Nemo-like kinase (NLK) is a serine/threonine kinase regulating the transcription factor by negatively regulating Wnt and downstream vascular endothelial growth factor receptor 2 (VEGFR2) signalling. This study aimed to investigate whether NLK expression in melanoma correlates with VEGFR2-related angiogenesis and melanoma metastasis. Immunohistochemistry analysis using 175 biopsied tissues of melanoma patients showed that NLK is expressed in 73.7% of melanoma tissues, whereas 26.3% of the samples showed absent expression of NLK. In metastatic melanoma, the expression of NLK was significantly lower than that in primary melanoma (P = 0.002). Furthermore, tissues with a lower expression of NLK showed a higher microvessel density as detected by VEGFR2 expression compared with tissues showing higher NLK expression. These data suggest that reduced expression of NLK in melanoma correlates with VEGFR2-related microvessel formation and melanoma metastasis. This study showed that NLK may serve as a novel prognosis marker and revealed new mechanisms in melanoma metastasis.
(Less)
- author
- Yang, Yvying ; Zhe, Hong ; Massoumi, Ramin LU and Ke, Hengning
- organization
- publishing date
- 2019-08
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Melanoma Research
- volume
- 29
- issue
- 4
- pages
- 6 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:30778016
- scopus:85069155549
- ISSN
- 0960-8931
- DOI
- 10.1097/CMR.0000000000000576
- language
- English
- LU publication?
- yes
- id
- 3557cb79-d569-4e71-8ba7-b3718c1a375f
- date added to LUP
- 2019-07-26 09:47:29
- date last changed
- 2024-05-14 19:49:44
@article{3557cb79-d569-4e71-8ba7-b3718c1a375f,
abstract = {{<p>Melanoma is a highly metastatic cancer, and its incidence has increased over the past several decades. Angiogenesis is associated with melanoma metastasis and a poor prognosis. Many genetic and epigenetic factors affecting tumour vascularization and metastasis have been investigated, despite the heterogeneity of cancer cells and the complicated mechanisms involved in melanoma. Nemo-like kinase (NLK) is a serine/threonine kinase regulating the transcription factor by negatively regulating Wnt and downstream vascular endothelial growth factor receptor 2 (VEGFR2) signalling. This study aimed to investigate whether NLK expression in melanoma correlates with VEGFR2-related angiogenesis and melanoma metastasis. Immunohistochemistry analysis using 175 biopsied tissues of melanoma patients showed that NLK is expressed in 73.7% of melanoma tissues, whereas 26.3% of the samples showed absent expression of NLK. In metastatic melanoma, the expression of NLK was significantly lower than that in primary melanoma (P = 0.002). Furthermore, tissues with a lower expression of NLK showed a higher microvessel density as detected by VEGFR2 expression compared with tissues showing higher NLK expression. These data suggest that reduced expression of NLK in melanoma correlates with VEGFR2-related microvessel formation and melanoma metastasis. This study showed that NLK may serve as a novel prognosis marker and revealed new mechanisms in melanoma metastasis.</p>}},
author = {{Yang, Yvying and Zhe, Hong and Massoumi, Ramin and Ke, Hengning}},
issn = {{0960-8931}},
language = {{eng}},
number = {{4}},
pages = {{376--381}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Melanoma Research}},
title = {{Decreased expression of nemo-like kinase in melanoma is correlated with increased vascularity and metastasis}},
url = {{http://dx.doi.org/10.1097/CMR.0000000000000576}},
doi = {{10.1097/CMR.0000000000000576}},
volume = {{29}},
year = {{2019}},
}