Detection of Bax Microsatellite Mutations and BaxΔ2 Isoform in Human Buccal Cells
(2015) In Journal of cell science & therapy 6(Suppl 8).- Abstract
Loss of the pro-apoptotic Bcl-2 family protein Bax occurs in ~50% of hereditary nonpolyposis colorectal cancer (HNPCC) due to microsatellite instability (MSI). Recently, we found that some of the "Bax-negative" MSI tumor cells contain a functional Bax isoform, BaxΔ2, which sensitizes cells to selective chemotherapeutics. Here we show the detection of Bax microsatellite mutations and expression of BaxΔ2 proteins in human buccal cells. Our study provides a sensitive and non-invasive approach and a potential clinical application in diagnosis and treatment of MSI colon cancer patients.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/356b13cd-9395-45c8-b0d0-bc469e5409f9
- author
- Zhang, Honghong ; Tassone, Cecilie ; Lin, Nora ; Mañas, Adriana LU ; Zhao, Yu and Xiang, Jialing
- publishing date
- 2015-09
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of cell science & therapy
- volume
- 6
- issue
- Suppl 8
- article number
- 002
- publisher
- Longdom Group SA
- external identifiers
-
- pmid:29302381
- ISSN
- 2157-7013
- DOI
- 10.4172/2157-7013.S8-002
- language
- English
- LU publication?
- no
- id
- 356b13cd-9395-45c8-b0d0-bc469e5409f9
- alternative location
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749267/
- date added to LUP
- 2020-04-22 15:54:56
- date last changed
- 2020-04-23 11:30:03
@article{356b13cd-9395-45c8-b0d0-bc469e5409f9,
abstract = {{<p>Loss of the pro-apoptotic Bcl-2 family protein Bax occurs in ~50% of hereditary nonpolyposis colorectal cancer (HNPCC) due to microsatellite instability (MSI). Recently, we found that some of the "Bax-negative" MSI tumor cells contain a functional Bax isoform, BaxΔ2, which sensitizes cells to selective chemotherapeutics. Here we show the detection of Bax microsatellite mutations and expression of BaxΔ2 proteins in human buccal cells. Our study provides a sensitive and non-invasive approach and a potential clinical application in diagnosis and treatment of MSI colon cancer patients.</p>}},
author = {{Zhang, Honghong and Tassone, Cecilie and Lin, Nora and Mañas, Adriana and Zhao, Yu and Xiang, Jialing}},
issn = {{2157-7013}},
language = {{eng}},
number = {{Suppl 8}},
publisher = {{Longdom Group SA}},
series = {{Journal of cell science & therapy}},
title = {{Detection of Bax Microsatellite Mutations and BaxΔ2 Isoform in Human Buccal Cells}},
url = {{http://dx.doi.org/10.4172/2157-7013.S8-002}},
doi = {{10.4172/2157-7013.S8-002}},
volume = {{6}},
year = {{2015}},
}