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Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

Lukoyanov, Nikolay ; Watanabe, Hiroyuki LU ; Carvalho, Liliana S. ; Kononenko, Olga ; Sarkisyan, Daniil ; Zhang, Mengliang LU ; Andersen, Marlene Storm ; Lukoyanova, Elena A. ; Galatenko, Vladimir and Tonevitsky, Alex , et al. (2021) In eLife 10.
Abstract

Brain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetry in gene expression patterns in the lumbar spinal cord. The injury-induced postural effects were abolished by hypophysectomy and were mimicked by transfusion of serum from animals with brain injury. Administration of the pituitary neurohormones b-endorphin or Arg-vasopressin-induced side-specific hindlimb responses in naive animals, while... (More)

Brain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetry in gene expression patterns in the lumbar spinal cord. The injury-induced postural effects were abolished by hypophysectomy and were mimicked by transfusion of serum from animals with brain injury. Administration of the pituitary neurohormones b-endorphin or Arg-vasopressin-induced side-specific hindlimb responses in naive animals, while antagonists of the opioid and vasopressin receptors blocked hindlimb postural asymmetry in rats with brain injury. Thus, in addition to the well-established involvement of motor pathways descending from the brain to spinal circuits, the side-specific humoral signaling may also add to postural and reflex asymmetries seen after brain injury.

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publishing date
type
Contribution to journal
publication status
published
subject
in
eLife
volume
10
article number
e65247
publisher
eLife Sciences Publications
external identifiers
  • pmid:34372969
  • scopus:85113795627
ISSN
2050-084X
DOI
10.7554/ELIFE.65247
language
English
LU publication?
yes
id
357701f8-aada-4b19-9b42-38da99cc2ee7
date added to LUP
2021-09-27 13:13:00
date last changed
2024-06-15 16:56:09
@article{357701f8-aada-4b19-9b42-38da99cc2ee7,
  abstract     = {{<p>Brain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetry in gene expression patterns in the lumbar spinal cord. The injury-induced postural effects were abolished by hypophysectomy and were mimicked by transfusion of serum from animals with brain injury. Administration of the pituitary neurohormones b-endorphin or Arg-vasopressin-induced side-specific hindlimb responses in naive animals, while antagonists of the opioid and vasopressin receptors blocked hindlimb postural asymmetry in rats with brain injury. Thus, in addition to the well-established involvement of motor pathways descending from the brain to spinal circuits, the side-specific humoral signaling may also add to postural and reflex asymmetries seen after brain injury.</p>}},
  author       = {{Lukoyanov, Nikolay and Watanabe, Hiroyuki and Carvalho, Liliana S. and Kononenko, Olga and Sarkisyan, Daniil and Zhang, Mengliang and Andersen, Marlene Storm and Lukoyanova, Elena A. and Galatenko, Vladimir and Tonevitsky, Alex and Bazov, Igor and Iakovleva, Tatiana and Schouenborg, Jens and Bakalkin, Georgy}},
  issn         = {{2050-084X}},
  language     = {{eng}},
  publisher    = {{eLife Sciences Publications}},
  series       = {{eLife}},
  title        = {{Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury}},
  url          = {{http://dx.doi.org/10.7554/ELIFE.65247}},
  doi          = {{10.7554/ELIFE.65247}},
  volume       = {{10}},
  year         = {{2021}},
}