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The effects of CGRP in vascular tissue - Classical vasodilation, shadowed effects and systemic dilemmas

Sohn, Iben ; Sheykhzade, Majid ; Edvinsson, Lars LU and Sams, Anette (2020) In European Journal of Pharmacology 881.
Abstract

Vascular tissue consists of endothelial cells, vasoactive smooth muscle cells and perivascular nerves. The perivascular sensory neuropeptide CGRP has demonstrated potent vasodilatory effects in any arterial vasculature examined so far, and a local protective CGRP-circuit of sensory nerve terminal CGRP release and smooth muscle cell CGRP action is evident. The significant vasodilatory effect has shadowed multiple other effects of CGRP in the vascular tissue and we therefore thoroughly review vascular actions of CGRP on endothelial cells, vascular smooth muscle cells and perivascular nerve terminals. The actions beyond vasodilation includes neuronal re-uptake and neuromodulation, angiogenic, proliferative and antiproliferative, pro- and... (More)

Vascular tissue consists of endothelial cells, vasoactive smooth muscle cells and perivascular nerves. The perivascular sensory neuropeptide CGRP has demonstrated potent vasodilatory effects in any arterial vasculature examined so far, and a local protective CGRP-circuit of sensory nerve terminal CGRP release and smooth muscle cell CGRP action is evident. The significant vasodilatory effect has shadowed multiple other effects of CGRP in the vascular tissue and we therefore thoroughly review vascular actions of CGRP on endothelial cells, vascular smooth muscle cells and perivascular nerve terminals. The actions beyond vasodilation includes neuronal re-uptake and neuromodulation, angiogenic, proliferative and antiproliferative, pro- and anti-inflammatory actions which vary depending on the target cell and anatomical location. In addition to the classical perivascular nerve-smooth muscle CGRP circuit, we review existing evidence for a shadowed endothelial autocrine pathway for CGRP. Finally, we discuss the impact of local and systemic actions of CGRP in vascular regulation and protection from hypertensive and ischemic heart conditions with special focus on therapeutic CGRP agonists and antagonists.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CGRP, Endothelial cells, Heart, Ischemic heart, Vascular effects, Vascular smooth muscle cells
in
European Journal of Pharmacology
volume
881
article number
173205
publisher
Elsevier
external identifiers
  • scopus:85085763833
  • pmid:32442540
ISSN
0014-2999
DOI
10.1016/j.ejphar.2020.173205
language
English
LU publication?
yes
id
3580f701-360e-4f68-8f00-6bdc024c0b31
date added to LUP
2021-01-14 11:10:22
date last changed
2024-04-03 21:49:14
@article{3580f701-360e-4f68-8f00-6bdc024c0b31,
  abstract     = {{<p>Vascular tissue consists of endothelial cells, vasoactive smooth muscle cells and perivascular nerves. The perivascular sensory neuropeptide CGRP has demonstrated potent vasodilatory effects in any arterial vasculature examined so far, and a local protective CGRP-circuit of sensory nerve terminal CGRP release and smooth muscle cell CGRP action is evident. The significant vasodilatory effect has shadowed multiple other effects of CGRP in the vascular tissue and we therefore thoroughly review vascular actions of CGRP on endothelial cells, vascular smooth muscle cells and perivascular nerve terminals. The actions beyond vasodilation includes neuronal re-uptake and neuromodulation, angiogenic, proliferative and antiproliferative, pro- and anti-inflammatory actions which vary depending on the target cell and anatomical location. In addition to the classical perivascular nerve-smooth muscle CGRP circuit, we review existing evidence for a shadowed endothelial autocrine pathway for CGRP. Finally, we discuss the impact of local and systemic actions of CGRP in vascular regulation and protection from hypertensive and ischemic heart conditions with special focus on therapeutic CGRP agonists and antagonists.</p>}},
  author       = {{Sohn, Iben and Sheykhzade, Majid and Edvinsson, Lars and Sams, Anette}},
  issn         = {{0014-2999}},
  keywords     = {{CGRP; Endothelial cells; Heart; Ischemic heart; Vascular effects; Vascular smooth muscle cells}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Pharmacology}},
  title        = {{The effects of CGRP in vascular tissue - Classical vasodilation, shadowed effects and systemic dilemmas}},
  url          = {{http://dx.doi.org/10.1016/j.ejphar.2020.173205}},
  doi          = {{10.1016/j.ejphar.2020.173205}},
  volume       = {{881}},
  year         = {{2020}},
}