Advanced

Contact allergy to common ingredients in hair dyes

Sosted, Heidi; Rustemeyer, Thomas; Goncalo, Margarida; Bruze, Magnus LU ; Goossens, An; Gimenez-Arnau, Ana M.; Le Coz, Christophe J.; White, Ian R.; Diepgen, Thomas L. and Andersen, Klaus E., et al. (2013) In Contact Dermatitis 69(1). p.32-39
Abstract
Background p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed. Objectives To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist. Methods Two thousand nine hundred and thirty-nine consecutive patients in 12 dermatology clinics were patch tested with five hair dyes available from patch test suppliers. Furthermore, 22 frequently used hair dye ingredients not available from patch test suppliers were tested in subgroups of approximate to 500 patients each. Results A positive reaction to PPD was found in 4.5% of patients, and 2.8% reacted to... (More)
Background p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed. Objectives To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist. Methods Two thousand nine hundred and thirty-nine consecutive patients in 12 dermatology clinics were patch tested with five hair dyes available from patch test suppliers. Furthermore, 22 frequently used hair dye ingredients not available from patch test suppliers were tested in subgroups of approximate to 500 patients each. Results A positive reaction to PPD was found in 4.5% of patients, and 2.8% reacted to toluene-2,5-diamine (PTD), 1.8% to p-aminophenol, 1% to m-aminophenol, and 0.1% to resorcinol; all together, 5.3% (n=156). Dying hair was the most frequently reported cause of the allergy (55.4%); so-called temporary henna' tattoos were the cause in 8.5% of the cases. p-Methylaminophenol gave a reaction in 20 patients (2.2%), 3 of them with clinical relevance, and no co-reaction with the above five well-known hair dyes. Conclusions Hair dyes are the prime cause of PPD allergy. PPD identifies the majority of positive reactions to PTD, p-aminophenol and m-aminophenol, but not all, which justifies additional testing with hair dye ingredients from the used product. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
2-amino-3-hydroxypyridine, 3-nitro-p-hydroxyethylaminophenol, hair dye, allergy, m-aminophenol, p-aminophenol, p-methylaminophenol, PPD, p-phenylenediamine, p-toluenediamine, toluene-2, 5-diamine
in
Contact Dermatitis
volume
69
issue
1
pages
32 - 39
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000320774100003
  • scopus:84879379379
ISSN
0105-1873
DOI
10.1111/cod.12077
language
English
LU publication?
yes
id
35a43cc9-9e7e-4d0e-b070-5236b7446d41 (old id 3980056)
date added to LUP
2013-09-02 12:23:09
date last changed
2019-07-30 01:46:11
@article{35a43cc9-9e7e-4d0e-b070-5236b7446d41,
  abstract     = {Background p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed. Objectives To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist. Methods Two thousand nine hundred and thirty-nine consecutive patients in 12 dermatology clinics were patch tested with five hair dyes available from patch test suppliers. Furthermore, 22 frequently used hair dye ingredients not available from patch test suppliers were tested in subgroups of approximate to 500 patients each. Results A positive reaction to PPD was found in 4.5% of patients, and 2.8% reacted to toluene-2,5-diamine (PTD), 1.8% to p-aminophenol, 1% to m-aminophenol, and 0.1% to resorcinol; all together, 5.3% (n=156). Dying hair was the most frequently reported cause of the allergy (55.4%); so-called temporary henna' tattoos were the cause in 8.5% of the cases. p-Methylaminophenol gave a reaction in 20 patients (2.2%), 3 of them with clinical relevance, and no co-reaction with the above five well-known hair dyes. Conclusions Hair dyes are the prime cause of PPD allergy. PPD identifies the majority of positive reactions to PTD, p-aminophenol and m-aminophenol, but not all, which justifies additional testing with hair dye ingredients from the used product.},
  author       = {Sosted, Heidi and Rustemeyer, Thomas and Goncalo, Margarida and Bruze, Magnus and Goossens, An and Gimenez-Arnau, Ana M. and Le Coz, Christophe J. and White, Ian R. and Diepgen, Thomas L. and Andersen, Klaus E. and Agner, Tove and Maibach, Howard and Menne, Torkil and Johansen, Jeanne D.},
  issn         = {0105-1873},
  keyword      = {2-amino-3-hydroxypyridine,3-nitro-p-hydroxyethylaminophenol,hair dye,allergy,m-aminophenol,p-aminophenol,p-methylaminophenol,PPD,p-phenylenediamine,p-toluenediamine,toluene-2,5-diamine},
  language     = {eng},
  number       = {1},
  pages        = {32--39},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Contact allergy to common ingredients in hair dyes},
  url          = {http://dx.doi.org/10.1111/cod.12077},
  volume       = {69},
  year         = {2013},
}