Helicobacter pylori Seropositivity, ABO Blood Type, and Pancreatic Cancer Risk From 5 Prospective Cohorts
Lee, Alice A ; Wang, Qiao-Li LU
; Kim, Jihye
; Babic, Ana
; Zhang, Xuehong
; Perez, Kimberly
; Ng, Kimmie
; Nowak, Jonathan
; Rifai, Nader
and Sesso, Howard D
, et al.
(2023)
In Clinical and translational gastroenterology
14(5).
- Abstract
BACKGROUND: Helicobacter pylori infection may be a risk factor for pancreatic cancer, particularly infection by strains without the cytotoxin-associated gene A (CagA) virulence factor. Non-O blood type is a known risk factor for pancreatic cancer, and H. pylori gastric colonization occurs largely from bacterial adhesins binding to blood group antigens on gastric mucosa.
METHODS: We included 485 pancreatic cancer cases and 1,122 matched controls from 5 U.S. prospective cohorts. Prediagnostic plasma samples were assessed for H. pylori and CagA antibody titers. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for pancreatic cancer. ABO blood type was assessed using genetic... (More)
BACKGROUND: Helicobacter pylori infection may be a risk factor for pancreatic cancer, particularly infection by strains without the cytotoxin-associated gene A (CagA) virulence factor. Non-O blood type is a known risk factor for pancreatic cancer, and H. pylori gastric colonization occurs largely from bacterial adhesins binding to blood group antigens on gastric mucosa.
METHODS: We included 485 pancreatic cancer cases and 1,122 matched controls from 5 U.S. prospective cohorts. Prediagnostic plasma samples were assessed for H. pylori and CagA antibody titers. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for pancreatic cancer. ABO blood type was assessed using genetic polymorphisms at the ABO gene locus or self-report.
RESULTS: Compared with H. pylori -seronegative participants, those who were seropositive did not demonstrate an increased risk of pancreatic cancer (OR 0.83, 95% CI 0.65-1.06). This lack of association was similar among CagA-seropositive (OR 0.75, 95% CI 0.53-1.04) and -seronegative (OR 0.89, 95% CI 0.65-1.20) participants. The association was also similar when stratified by time between blood collection and cancer diagnosis ( P -interaction = 0.80). Consistent with previous studies, non-O blood type was associated with increased pancreatic cancer risk, but this increase in risk was similar regardless of H. pylori seropositivity ( P -interaction = 0.51).
DISCUSSION: In this nested case-control study, history of H. pylori infection as determined by H. pylori antibody serology was not associated with pancreatic cancer risk, regardless of CagA virulence factor status. The elevated risk associated with non-O blood type was consistent in those with or without H. pylori seropositivity.
(Less)
- author
- Lee, Alice A
; Wang, Qiao-Li
LU
; Kim, Jihye
; Babic, Ana
; Zhang, Xuehong
; Perez, Kimberly
; Ng, Kimmie
; Nowak, Jonathan
; Rifai, Nader
and Sesso, Howard D
, et al. (More)
- Lee, Alice A
; Wang, Qiao-Li
LU
; Kim, Jihye
; Babic, Ana
; Zhang, Xuehong
; Perez, Kimberly
; Ng, Kimmie
; Nowak, Jonathan
; Rifai, Nader
; Sesso, Howard D
; Buring, Julie E
; Anderson, Garnet L
; Wactawski-Wende, Jean
; Wallace, Robert
; Manson, JoAnn E
; Giovannucci, Edward L
; Stampfer, Meir J
; Kraft, Peter
; Fuchs, Charles S
; Yuan, Chen
and Wolpin, Brian M
(Less)
- publishing date
- 2023-05-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Humans, Bacterial Proteins, Antigens, Bacterial, Helicobacter pylori, Prospective Studies, Helicobacter Infections/complications, Case-Control Studies, Pancreatic Neoplasms/etiology
- in
- Clinical and translational gastroenterology
- volume
- 14
- issue
- 5
- article number
- e00573
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85149493023
- pmid:36854058
- ISSN
- 2155-384X
- DOI
- 10.14309/ctg.0000000000000573
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
- id
- 36122b65-6ed0-406f-9d8f-4b889594b146
- date added to LUP
- 2025-05-12 17:09:58
- date last changed
- 2025-06-10 06:57:56
@article{36122b65-6ed0-406f-9d8f-4b889594b146,
abstract = {{<p>BACKGROUND: Helicobacter pylori infection may be a risk factor for pancreatic cancer, particularly infection by strains without the cytotoxin-associated gene A (CagA) virulence factor. Non-O blood type is a known risk factor for pancreatic cancer, and H. pylori gastric colonization occurs largely from bacterial adhesins binding to blood group antigens on gastric mucosa.</p><p>METHODS: We included 485 pancreatic cancer cases and 1,122 matched controls from 5 U.S. prospective cohorts. Prediagnostic plasma samples were assessed for H. pylori and CagA antibody titers. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for pancreatic cancer. ABO blood type was assessed using genetic polymorphisms at the ABO gene locus or self-report.</p><p>RESULTS: Compared with H. pylori -seronegative participants, those who were seropositive did not demonstrate an increased risk of pancreatic cancer (OR 0.83, 95% CI 0.65-1.06). This lack of association was similar among CagA-seropositive (OR 0.75, 95% CI 0.53-1.04) and -seronegative (OR 0.89, 95% CI 0.65-1.20) participants. The association was also similar when stratified by time between blood collection and cancer diagnosis ( P -interaction = 0.80). Consistent with previous studies, non-O blood type was associated with increased pancreatic cancer risk, but this increase in risk was similar regardless of H. pylori seropositivity ( P -interaction = 0.51).</p><p>DISCUSSION: In this nested case-control study, history of H. pylori infection as determined by H. pylori antibody serology was not associated with pancreatic cancer risk, regardless of CagA virulence factor status. The elevated risk associated with non-O blood type was consistent in those with or without H. pylori seropositivity.</p>}},
author = {{Lee, Alice A and Wang, Qiao-Li and Kim, Jihye and Babic, Ana and Zhang, Xuehong and Perez, Kimberly and Ng, Kimmie and Nowak, Jonathan and Rifai, Nader and Sesso, Howard D and Buring, Julie E and Anderson, Garnet L and Wactawski-Wende, Jean and Wallace, Robert and Manson, JoAnn E and Giovannucci, Edward L and Stampfer, Meir J and Kraft, Peter and Fuchs, Charles S and Yuan, Chen and Wolpin, Brian M}},
issn = {{2155-384X}},
keywords = {{Humans; Bacterial Proteins; Antigens, Bacterial; Helicobacter pylori; Prospective Studies; Helicobacter Infections/complications; Case-Control Studies; Pancreatic Neoplasms/etiology}},
language = {{eng}},
month = {{05}},
number = {{5}},
publisher = {{Nature Publishing Group}},
series = {{Clinical and translational gastroenterology}},
title = {{Helicobacter pylori Seropositivity, ABO Blood Type, and Pancreatic Cancer Risk From 5 Prospective Cohorts}},
url = {{http://dx.doi.org/10.14309/ctg.0000000000000573}},
doi = {{10.14309/ctg.0000000000000573}},
volume = {{14}},
year = {{2023}},
}