Release of PACAP-38 in episodic cluster headache patients - An exploratory study
(2016) In Journal of Headache and Pain 17(1).- Abstract
Background: Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and the trigeminal ganglion (TG) and its role in migraine has been described, our aim was to determine the plasma PACAP-38 levels in different phases of episodic CH (ECH). Peripheral cubital fossa blood samples were taken during the ictal and inter-bout periods of male ECH patients and from age-matched healthy controls (n = 9). Plasma PACAP-38-like immunoreactivity (LI) was measured with specific and sensitive... (More)
Background: Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and the trigeminal ganglion (TG) and its role in migraine has been described, our aim was to determine the plasma PACAP-38 levels in different phases of episodic CH (ECH). Peripheral cubital fossa blood samples were taken during the ictal and inter-bout periods of male ECH patients and from age-matched healthy controls (n = 9). Plasma PACAP-38-like immunoreactivity (LI) was measured with specific and sensitive radioimmunoassay. Findings: Significantly lower plasma PACAP-38-LI was detected in the inter-bout period of ECH patients than in healthy controls. However, PACAP-38 was significantly elevated in the plasma during CH attacks as compared to the inter-bout phase in the same subjects (n =5). Conclusions: This exploratory study suggests that PACAP-38 may be released during the attacks of ECH. Further patients and long-term follow-up are necessary to reveal its function.
(Less)
- author
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Episodic cluster headache, Ictal phase, Inter-bout period, Plasma PACAP-38-LI
- in
- Journal of Headache and Pain
- volume
- 17
- issue
- 1
- article number
- 69
- publisher
- Springer
- external identifiers
-
- scopus:85007553368
- pmid:27475101
- wos:000381220100002
- ISSN
- 1129-2369
- DOI
- 10.1186/s10194-016-0660-7
- language
- English
- LU publication?
- yes
- id
- 3615ee1d-a486-4e67-ba02-9851abc0c224
- date added to LUP
- 2017-01-19 15:02:00
- date last changed
- 2025-01-25 21:39:31
@article{3615ee1d-a486-4e67-ba02-9851abc0c224, abstract = {{<p>Background: Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and the trigeminal ganglion (TG) and its role in migraine has been described, our aim was to determine the plasma PACAP-38 levels in different phases of episodic CH (ECH). Peripheral cubital fossa blood samples were taken during the ictal and inter-bout periods of male ECH patients and from age-matched healthy controls (n = 9). Plasma PACAP-38-like immunoreactivity (LI) was measured with specific and sensitive radioimmunoassay. Findings: Significantly lower plasma PACAP-38-LI was detected in the inter-bout period of ECH patients than in healthy controls. However, PACAP-38 was significantly elevated in the plasma during CH attacks as compared to the inter-bout phase in the same subjects (n =5). Conclusions: This exploratory study suggests that PACAP-38 may be released during the attacks of ECH. Further patients and long-term follow-up are necessary to reveal its function.</p>}}, author = {{Tuka, Bernadett and Szabó, Nikoletta and Tóth, Eszter and Kincses, Zsigmond Tamás and Párdutz, Árpád and Szok, Délia and Körtési, Tamás and Bagoly, Teréz and Helyes, Zsuzsanna and Edvinsson, Lars and Vécsei, László and Tajti, János}}, issn = {{1129-2369}}, keywords = {{Episodic cluster headache; Ictal phase; Inter-bout period; Plasma PACAP-38-LI}}, language = {{eng}}, number = {{1}}, publisher = {{Springer}}, series = {{Journal of Headache and Pain}}, title = {{Release of PACAP-38 in episodic cluster headache patients - An exploratory study}}, url = {{http://dx.doi.org/10.1186/s10194-016-0660-7}}, doi = {{10.1186/s10194-016-0660-7}}, volume = {{17}}, year = {{2016}}, }