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Release of PACAP-38 in episodic cluster headache patients - An exploratory study

Tuka, Bernadett; Szabó, Nikoletta; Tóth, Eszter; Kincses, Zsigmond Tamás; Párdutz, Árpád; Szok, Délia; Körtési, Tamás; Bagoly, Teréz; Helyes, Zsuzsanna and Edvinsson, Lars LU , et al. (2016) In Journal of Headache and Pain 17(1).
Abstract

Background: Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and the trigeminal ganglion (TG) and its role in migraine has been described, our aim was to determine the plasma PACAP-38 levels in different phases of episodic CH (ECH). Peripheral cubital fossa blood samples were taken during the ictal and inter-bout periods of male ECH patients and from age-matched healthy controls (n = 9). Plasma PACAP-38-like immunoreactivity (LI) was measured with specific and sensitive... (More)

Background: Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and the trigeminal ganglion (TG) and its role in migraine has been described, our aim was to determine the plasma PACAP-38 levels in different phases of episodic CH (ECH). Peripheral cubital fossa blood samples were taken during the ictal and inter-bout periods of male ECH patients and from age-matched healthy controls (n = 9). Plasma PACAP-38-like immunoreactivity (LI) was measured with specific and sensitive radioimmunoassay. Findings: Significantly lower plasma PACAP-38-LI was detected in the inter-bout period of ECH patients than in healthy controls. However, PACAP-38 was significantly elevated in the plasma during CH attacks as compared to the inter-bout phase in the same subjects (n =5). Conclusions: This exploratory study suggests that PACAP-38 may be released during the attacks of ECH. Further patients and long-term follow-up are necessary to reveal its function.

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keywords
Episodic cluster headache, Ictal phase, Inter-bout period, Plasma PACAP-38-LI
in
Journal of Headache and Pain
volume
17
issue
1
publisher
Springer
external identifiers
  • scopus:85007553368
  • wos:000381220100002
ISSN
1129-2369
DOI
10.1186/s10194-016-0660-7
language
English
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yes
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3615ee1d-a486-4e67-ba02-9851abc0c224
date added to LUP
2017-01-19 15:02:00
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2017-10-01 05:29:05
@article{3615ee1d-a486-4e67-ba02-9851abc0c224,
  abstract     = {<p>Background: Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and the trigeminal ganglion (TG) and its role in migraine has been described, our aim was to determine the plasma PACAP-38 levels in different phases of episodic CH (ECH). Peripheral cubital fossa blood samples were taken during the ictal and inter-bout periods of male ECH patients and from age-matched healthy controls (n = 9). Plasma PACAP-38-like immunoreactivity (LI) was measured with specific and sensitive radioimmunoassay. Findings: Significantly lower plasma PACAP-38-LI was detected in the inter-bout period of ECH patients than in healthy controls. However, PACAP-38 was significantly elevated in the plasma during CH attacks as compared to the inter-bout phase in the same subjects (n =5). Conclusions: This exploratory study suggests that PACAP-38 may be released during the attacks of ECH. Further patients and long-term follow-up are necessary to reveal its function.</p>},
  articleno    = {69},
  author       = {Tuka, Bernadett and Szabó, Nikoletta and Tóth, Eszter and Kincses, Zsigmond Tamás and Párdutz, Árpád and Szok, Délia and Körtési, Tamás and Bagoly, Teréz and Helyes, Zsuzsanna and Edvinsson, Lars and Vécsei, László and Tajti, János},
  issn         = {1129-2369},
  keyword      = {Episodic cluster headache,Ictal phase,Inter-bout period,Plasma PACAP-38-LI},
  language     = {eng},
  number       = {1},
  publisher    = {Springer},
  series       = {Journal of Headache and Pain},
  title        = {Release of PACAP-38 in episodic cluster headache patients - An exploratory study},
  url          = {http://dx.doi.org/10.1186/s10194-016-0660-7},
  volume       = {17},
  year         = {2016},
}