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Islet Cell Cytoplasmic Antibodies (ICA) in Diabetes and Disorders of Glucose Tolerance

Marner, B. ; Bille, G. ; Christy, M. ; Damsgaard, E. M. ; Garne, S. ; Heinze, E. ; Larsen, S. ; Lernmark, Å LU orcid ; Mandrup‐Poulsen, T. and Nerup, J. LU , et al. (1991) In Diabetic Medicine 8(9). p.812-816
Abstract

Islet cell cytoplasmic antibodies were determined in 85 individuals 60 to 74 years old with fasting hyperglycaemia, in 65 patients with cystic fibrosis, in 113 patients with pancreatitis, in 21 patients with Turner's phenotype, and in 135 first‐degree relatives of patients with Type 1 (insulin‐dependent) diabetes. Islet cell antibodies were absent in all 60 to 74‐year‐old subjects with fasting hyperglycaemia detected by screening, and who did not require insulin treatment within 3 years. Islet cell antibodies were also absent in all patients with pancreatitis, cystic fibrosis, or Turner's phenotype. Islet cell antibodies were detected in 2 out of 135 (1.5 %) first‐degree relatives of new Type 1 diabetic patients, and in 1 out of 371... (More)

Islet cell cytoplasmic antibodies were determined in 85 individuals 60 to 74 years old with fasting hyperglycaemia, in 65 patients with cystic fibrosis, in 113 patients with pancreatitis, in 21 patients with Turner's phenotype, and in 135 first‐degree relatives of patients with Type 1 (insulin‐dependent) diabetes. Islet cell antibodies were absent in all 60 to 74‐year‐old subjects with fasting hyperglycaemia detected by screening, and who did not require insulin treatment within 3 years. Islet cell antibodies were also absent in all patients with pancreatitis, cystic fibrosis, or Turner's phenotype. Islet cell antibodies were detected in 2 out of 135 (1.5 %) first‐degree relatives of new Type 1 diabetic patients, and in 1 out of 371 (0.3%) non‐diabetic control subjects. During 12 years of follow‐up 1 of the 2 first‐degree relatives with islet cell antibodies and the only positive control developed Type 1 diabetes. It is suggested that islet cell antibodies are primarily associated with Type 1 diabetes and not with other disorders of glucose tolerance. 1991 Diabetes UK

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cystic fibrosis, Diabetes mellitus, Family history, Islet cell antibodies, Pancreatitis, Relatives, Turner's syndrome
in
Diabetic Medicine
volume
8
issue
9
pages
812 - 816
publisher
Wiley-Blackwell
external identifiers
  • scopus:0026004451
  • pmid:1837507
ISSN
0742-3071
DOI
10.1111/j.1464-5491.1991.tb02118.x
language
English
LU publication?
no
id
361ecf61-cabc-43a1-8356-6220118ed7c7
date added to LUP
2019-09-11 09:37:26
date last changed
2024-03-13 08:15:08
@article{361ecf61-cabc-43a1-8356-6220118ed7c7,
  abstract     = {{<p>Islet cell cytoplasmic antibodies were determined in 85 individuals 60 to 74 years old with fasting hyperglycaemia, in 65 patients with cystic fibrosis, in 113 patients with pancreatitis, in 21 patients with Turner's phenotype, and in 135 first‐degree relatives of patients with Type 1 (insulin‐dependent) diabetes. Islet cell antibodies were absent in all 60 to 74‐year‐old subjects with fasting hyperglycaemia detected by screening, and who did not require insulin treatment within 3 years. Islet cell antibodies were also absent in all patients with pancreatitis, cystic fibrosis, or Turner's phenotype. Islet cell antibodies were detected in 2 out of 135 (1.5 %) first‐degree relatives of new Type 1 diabetic patients, and in 1 out of 371 (0.3%) non‐diabetic control subjects. During 12 years of follow‐up 1 of the 2 first‐degree relatives with islet cell antibodies and the only positive control developed Type 1 diabetes. It is suggested that islet cell antibodies are primarily associated with Type 1 diabetes and not with other disorders of glucose tolerance. 1991 Diabetes UK</p>}},
  author       = {{Marner, B. and Bille, G. and Christy, M. and Damsgaard, E. M. and Garne, S. and Heinze, E. and Larsen, S. and Lernmark, Å and Mandrup‐Poulsen, T. and Nerup, J. and Schroll, M.}},
  issn         = {{0742-3071}},
  keywords     = {{Cystic fibrosis; Diabetes mellitus; Family history; Islet cell antibodies; Pancreatitis; Relatives; Turner's syndrome}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{9}},
  pages        = {{812--816}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Diabetic Medicine}},
  title        = {{Islet Cell Cytoplasmic Antibodies (ICA) in Diabetes and Disorders of Glucose Tolerance}},
  url          = {{http://dx.doi.org/10.1111/j.1464-5491.1991.tb02118.x}},
  doi          = {{10.1111/j.1464-5491.1991.tb02118.x}},
  volume       = {{8}},
  year         = {{1991}},
}