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The MSC-EV-microRNAome : A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS

dos Santos, Claudia C. ; Lopes-Pacheco, Miquéias ; English, Karen ; Rolandsson Enes, Sara LU orcid ; Krasnodembskaya, Anna and Rocco, Patricia R.M. (2024) In Cells 13(2).
Abstract

Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory distress syndrome (ARDS). Although their potential remains undisputed in pre-clinical models, this has yet to be translated to the clinic. In this review, we focused on the role of microRNAs contained in MSC-derived EVs, the EV microRNAome, and their potential contribution to therapeutic mechanisms of action. The evidence that miRNA transfer in MSC-derived EVs has a role in the overall therapeutic effects is compelling. However, several questions remain regarding how to reconcile the stochiometric issue of the low copy numbers of the miRNAs present in the EV... (More)

Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory distress syndrome (ARDS). Although their potential remains undisputed in pre-clinical models, this has yet to be translated to the clinic. In this review, we focused on the role of microRNAs contained in MSC-derived EVs, the EV microRNAome, and their potential contribution to therapeutic mechanisms of action. The evidence that miRNA transfer in MSC-derived EVs has a role in the overall therapeutic effects is compelling. However, several questions remain regarding how to reconcile the stochiometric issue of the low copy numbers of the miRNAs present in the EV particles, how different miRNAs delivered simultaneously interact with their targets within recipient cells, and the best miRNA or combination of miRNAs to use as therapy, potency markers, and biomarkers of efficacy in the clinic. Here, we offer a molecular genetics and systems biology perspective on the function of EV microRNAs, their contribution to mechanisms of action, and their therapeutic potential.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute lung injury, acute respiratory distress syndrome, exosomes, extracellular vesicles, mesenchymal stromal cells, microRNA, nano therapy, sepsis, systems biology
in
Cells
volume
13
issue
2
article number
122
publisher
MDPI AG
external identifiers
  • pmid:38247814
  • scopus:85183082285
ISSN
2073-4409
DOI
10.3390/cells13020122
language
English
LU publication?
yes
id
3623b6ee-bfcc-4a94-9b79-7198f612294d
date added to LUP
2024-02-19 14:52:06
date last changed
2024-04-19 16:54:12
@article{3623b6ee-bfcc-4a94-9b79-7198f612294d,
  abstract     = {{<p>Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory distress syndrome (ARDS). Although their potential remains undisputed in pre-clinical models, this has yet to be translated to the clinic. In this review, we focused on the role of microRNAs contained in MSC-derived EVs, the EV microRNAome, and their potential contribution to therapeutic mechanisms of action. The evidence that miRNA transfer in MSC-derived EVs has a role in the overall therapeutic effects is compelling. However, several questions remain regarding how to reconcile the stochiometric issue of the low copy numbers of the miRNAs present in the EV particles, how different miRNAs delivered simultaneously interact with their targets within recipient cells, and the best miRNA or combination of miRNAs to use as therapy, potency markers, and biomarkers of efficacy in the clinic. Here, we offer a molecular genetics and systems biology perspective on the function of EV microRNAs, their contribution to mechanisms of action, and their therapeutic potential.</p>}},
  author       = {{dos Santos, Claudia C. and Lopes-Pacheco, Miquéias and English, Karen and Rolandsson Enes, Sara and Krasnodembskaya, Anna and Rocco, Patricia R.M.}},
  issn         = {{2073-4409}},
  keywords     = {{acute lung injury; acute respiratory distress syndrome; exosomes; extracellular vesicles; mesenchymal stromal cells; microRNA; nano therapy; sepsis; systems biology}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{MDPI AG}},
  series       = {{Cells}},
  title        = {{The MSC-EV-microRNAome : A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS}},
  url          = {{http://dx.doi.org/10.3390/cells13020122}},
  doi          = {{10.3390/cells13020122}},
  volume       = {{13}},
  year         = {{2024}},
}