Advanced

An international multicentre study on the allergenic activity of air-oxidized R-limonene.

Bråred Christensson, Johanna ; Andersen, Klaus E ; Bruze, Magnus LU ; Johansen, Jeanne D ; Garcia-Bravo, Begoña ; Giménez-Arnau, Ana ; Goh, Chee-Leok ; Nixon, Rosemary and White, Ian R (2013) In Contact Dermatitis 68(4). p.214-223
Abstract
Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United... (More)
Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3-12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0-24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
68
issue
4
pages
214 - 223
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000316630900003
  • pmid:23510342
  • scopus:84875331075
  • pmid:23510342
ISSN
0105-1873
DOI
10.1111/cod.12036
language
English
LU publication?
yes
id
914651b9-e3d4-4ffc-a6a7-e57d16311222 (old id 3627963)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23510342?dopt=Abstract
date added to LUP
2016-04-01 10:31:51
date last changed
2020-12-29 02:53:37
@article{914651b9-e3d4-4ffc-a6a7-e57d16311222,
  abstract     = {Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3-12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0-24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed.},
  author       = {Bråred Christensson, Johanna and Andersen, Klaus E and Bruze, Magnus and Johansen, Jeanne D and Garcia-Bravo, Begoña and Giménez-Arnau, Ana and Goh, Chee-Leok and Nixon, Rosemary and White, Ian R},
  issn         = {0105-1873},
  language     = {eng},
  number       = {4},
  pages        = {214--223},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {An international multicentre study on the allergenic activity of air-oxidized R-limonene.},
  url          = {http://dx.doi.org/10.1111/cod.12036},
  doi          = {10.1111/cod.12036},
  volume       = {68},
  year         = {2013},
}