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Contact allergies to potential allergens in patients with oral lichen lesions.

Ahlgren, Camilla ; Axéll, Tony ; Möller, Halvor LU ; Isaksson, Marléne LU ; Liedholm, Rolf and Bruze, Magnus LU (2014) In Clinical Oral Investigations 18(1). p.227-237
Abstract
OBJECTIVE: The aim of the present controlled study was to investigate a possible relationship between contact allergies to potential allergens and oral lichen lesions. METHODS: Eighty-three patients with oral lichen lesions (OLL) and control groups of age- and gender-matched dermatitis patients (DP, n = 83) and patch-tested dermatitis patients randomly selected from files (PSFF, n = 319) were included in the study. OLL and DP groups were patch-tested epicutaneously and examined intraorally. RESULTS: The frequencies of contact allergy to mercury and carvone were statistically higher in the OLL group than in the DP group. Surfaces of amalgam and composite restorations were statistically more frequent in the OLL group compared to the DP... (More)
OBJECTIVE: The aim of the present controlled study was to investigate a possible relationship between contact allergies to potential allergens and oral lichen lesions. METHODS: Eighty-three patients with oral lichen lesions (OLL) and control groups of age- and gender-matched dermatitis patients (DP, n = 83) and patch-tested dermatitis patients randomly selected from files (PSFF, n = 319) were included in the study. OLL and DP groups were patch-tested epicutaneously and examined intraorally. RESULTS: The frequencies of contact allergy to mercury and carvone were statistically higher in the OLL group than in the DP group. Surfaces of amalgam and composite restorations were statistically more frequent in the OLL group compared to the DP group. Contact allergy to nickel and colophony, the latter with a statistically significant difference, was more common in the DP group. The numerical difference found for nickel allergy was, however, not significant comparing the OLL and PSFF groups. CONCLUSION: Contact allergy to mercury was overrepresented in patients with OLL and has been reported in previous studies, but the present finding of an overrepresentation of contact allergy to carvone in patients with oral lichen lesions has not been reported previously. CLINICAL RELEVANCE: Carvone, in addition to mercury and gold, as previously suggested, can be one of the causative or maintenant factors for oral lichen lesions. Carvone-hypersensitive patients with oral lichen lesions should therefore avoid carvone-containing products for oral use. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Oral Investigations
volume
18
issue
1
pages
227 - 237
publisher
Springer
external identifiers
  • wos:000329094500025
  • pmid:23455574
  • scopus:84891559868
ISSN
1436-3771
DOI
10.1007/s00784-013-0950-2
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Occupational and Environmental Dermatology Unit (013241310)
id
3a2d5ad7-0bca-4736-84f8-ba781f5e706a (old id 3628681)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23455574?dopt=Abstract
date added to LUP
2016-04-01 10:31:35
date last changed
2022-04-27 22:58:41
@article{3a2d5ad7-0bca-4736-84f8-ba781f5e706a,
  abstract     = {{OBJECTIVE: The aim of the present controlled study was to investigate a possible relationship between contact allergies to potential allergens and oral lichen lesions. METHODS: Eighty-three patients with oral lichen lesions (OLL) and control groups of age- and gender-matched dermatitis patients (DP, n = 83) and patch-tested dermatitis patients randomly selected from files (PSFF, n = 319) were included in the study. OLL and DP groups were patch-tested epicutaneously and examined intraorally. RESULTS: The frequencies of contact allergy to mercury and carvone were statistically higher in the OLL group than in the DP group. Surfaces of amalgam and composite restorations were statistically more frequent in the OLL group compared to the DP group. Contact allergy to nickel and colophony, the latter with a statistically significant difference, was more common in the DP group. The numerical difference found for nickel allergy was, however, not significant comparing the OLL and PSFF groups. CONCLUSION: Contact allergy to mercury was overrepresented in patients with OLL and has been reported in previous studies, but the present finding of an overrepresentation of contact allergy to carvone in patients with oral lichen lesions has not been reported previously. CLINICAL RELEVANCE: Carvone, in addition to mercury and gold, as previously suggested, can be one of the causative or maintenant factors for oral lichen lesions. Carvone-hypersensitive patients with oral lichen lesions should therefore avoid carvone-containing products for oral use.}},
  author       = {{Ahlgren, Camilla and Axéll, Tony and Möller, Halvor and Isaksson, Marléne and Liedholm, Rolf and Bruze, Magnus}},
  issn         = {{1436-3771}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{227--237}},
  publisher    = {{Springer}},
  series       = {{Clinical Oral Investigations}},
  title        = {{Contact allergies to potential allergens in patients with oral lichen lesions.}},
  url          = {{http://dx.doi.org/10.1007/s00784-013-0950-2}},
  doi          = {{10.1007/s00784-013-0950-2}},
  volume       = {{18}},
  year         = {{2014}},
}