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Preoperative platelet-rich plasmapheresis and hemodilution with an autotransfusion device in total hip replacement surgery.

Ekbäck, G; Ryttberg, L; Axelsson, K; Christianssen, F; Kjellberg, J; Carlsson, P; Carlsson, O and Schött, Ulf LU (2000) In Journal of Clinical Apheresis 15(4). p.256-261
Abstract
The effectiveness of both preoperative autologous donation (PAD) and intraoperative autotransfusion (IAT) with an autotransfusion device has recently been questioned. Preoperative apheresis, with separation of concentrated platelet rich-plasma (c-PRP) and erythrocyte concentrate (ERC), represents an aggressive use of the autotransfusion device. Can such a procedure replace PAD in total hip replacement surgery (THR)? Eighty patients undergoing THR were investigated in a prospective and randomized study. Forty patients underwent PAD, and 2 units of ERC + plasma were retrieved within 4 weeks preoperatively. Another 40 patients underwent an immediately preoperative apheresis with a concomitant hemodilution with 4% albumin, retrieving c-PRP... (More)
The effectiveness of both preoperative autologous donation (PAD) and intraoperative autotransfusion (IAT) with an autotransfusion device has recently been questioned. Preoperative apheresis, with separation of concentrated platelet rich-plasma (c-PRP) and erythrocyte concentrate (ERC), represents an aggressive use of the autotransfusion device. Can such a procedure replace PAD in total hip replacement surgery (THR)? Eighty patients undergoing THR were investigated in a prospective and randomized study. Forty patients underwent PAD, and 2 units of ERC + plasma were retrieved within 4 weeks preoperatively. Another 40 patients underwent an immediately preoperative apheresis with a concomitant hemodilution with 4% albumin, retrieving c-PRP (30% of the platelet pool) and 2 units of ERC. Both groups used IAT up to 2 hours postoperatively, with 3% dextran-60 as a plasma substitute according to our standard of care. There were no differences in blood loss, B-hemoglobin or allogeneic transfusions between the groups: 85% of the patients did not receive allogeneic blood. Both apheresis and reinfusion of c-PRP had minor impact on the coagulation parameters. Platelet count increased slightly but significantly (P<0.05) from 154 to 179 x 10(9)/L after the c-PRP at wound closure. Preoperative apheresis with an autotransfusion device, separating platelet-rich plasma and erythrocyte concentrate, is a useful alternative for patients who are unable to utilize the PAD technique for either religious or practical reasons. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood Transfusion, Autologous: instrumentation
in
Journal of Clinical Apheresis
volume
15
issue
4
pages
256 - 261
publisher
Wiley-Liss Inc.
external identifiers
  • pmid:11124694
  • scopus:0034525338
ISSN
0733-2459
language
English
LU publication?
yes
id
d5b13181-97b2-43f9-a5b7-a6098905cd02 (old id 3634352)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/11124694?dopt=Abstract
date added to LUP
2013-07-02 13:05:17
date last changed
2017-01-01 07:31:16
@article{d5b13181-97b2-43f9-a5b7-a6098905cd02,
  abstract     = {The effectiveness of both preoperative autologous donation (PAD) and intraoperative autotransfusion (IAT) with an autotransfusion device has recently been questioned. Preoperative apheresis, with separation of concentrated platelet rich-plasma (c-PRP) and erythrocyte concentrate (ERC), represents an aggressive use of the autotransfusion device. Can such a procedure replace PAD in total hip replacement surgery (THR)? Eighty patients undergoing THR were investigated in a prospective and randomized study. Forty patients underwent PAD, and 2 units of ERC + plasma were retrieved within 4 weeks preoperatively. Another 40 patients underwent an immediately preoperative apheresis with a concomitant hemodilution with 4% albumin, retrieving c-PRP (30% of the platelet pool) and 2 units of ERC. Both groups used IAT up to 2 hours postoperatively, with 3% dextran-60 as a plasma substitute according to our standard of care. There were no differences in blood loss, B-hemoglobin or allogeneic transfusions between the groups: 85% of the patients did not receive allogeneic blood. Both apheresis and reinfusion of c-PRP had minor impact on the coagulation parameters. Platelet count increased slightly but significantly (P&lt;0.05) from 154 to 179 x 10(9)/L after the c-PRP at wound closure. Preoperative apheresis with an autotransfusion device, separating platelet-rich plasma and erythrocyte concentrate, is a useful alternative for patients who are unable to utilize the PAD technique for either religious or practical reasons.},
  author       = {Ekbäck, G and Ryttberg, L and Axelsson, K and Christianssen, F and Kjellberg, J and Carlsson, P and Carlsson, O and Schött, Ulf},
  issn         = {0733-2459},
  keyword      = {Blood Transfusion,Autologous: instrumentation},
  language     = {eng},
  number       = {4},
  pages        = {256--261},
  publisher    = {Wiley-Liss Inc.},
  series       = {Journal of Clinical Apheresis},
  title        = {Preoperative platelet-rich plasmapheresis and hemodilution with an autotransfusion device in total hip replacement surgery.},
  volume       = {15},
  year         = {2000},
}