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Hemodynamic effects of colloid concentration in experimental hemorrhage: a comparison of Ringer's acetate, 3% dextran-60, and 6% dextran-70.

Schött, Ulf LU ; Lindbom, L O and Sjöstrand, U (1988) In Critical Care Medicine 16(4). p.346-352
Abstract
Hemodynamic effects of iso-oncotic 3% dextran-60, 6% dextran-70, and Ringer's acetate were compared in 28 male pigs (25 to 30 kg) subjected to experimental trauma and hemorrhage. The animals were kept anesthetized with 75% N2O/25% O2, 0.8% halothane. Hemodynamic and respiratory conditions were allowed to stabilize for one hour preoperatively (baseline data). After surgical trauma (arthroplasty), three 0.5 L of arterial blood samples were withdrawn and replaced with autologous red cells mixed with one liter of 3% dextran-60 in one group 1 (n = 9), one liter of 6% dextran-70 in group 2 (n = 10), and 3 L of Ringer's acetate in group 3 (n = 9). Pulmonary capillary wedge pressure (WP) was kept at baseline level for a further 10 h with infusion... (More)
Hemodynamic effects of iso-oncotic 3% dextran-60, 6% dextran-70, and Ringer's acetate were compared in 28 male pigs (25 to 30 kg) subjected to experimental trauma and hemorrhage. The animals were kept anesthetized with 75% N2O/25% O2, 0.8% halothane. Hemodynamic and respiratory conditions were allowed to stabilize for one hour preoperatively (baseline data). After surgical trauma (arthroplasty), three 0.5 L of arterial blood samples were withdrawn and replaced with autologous red cells mixed with one liter of 3% dextran-60 in one group 1 (n = 9), one liter of 6% dextran-70 in group 2 (n = 10), and 3 L of Ringer's acetate in group 3 (n = 9). Pulmonary capillary wedge pressure (WP) was kept at baseline level for a further 10 h with infusion of the respective fluid; for this purpose, groups 1 through 3 needed additional infusions of 0.8 +/- 0.3, 0.5 +/- 0.4, and 5.3 +/- 3 (SD) L, respectively. Group 1 showed the highest jejunal capillary blood flow at 10 h and the lowest intragroup variations in hemodynamic and respiratory data. Group 2 had the highest pulmonary arterial pressures and group 3 had the lowest colloid oncotic and arterial BP and left ventricular volume indices. In group 3, the Hct and serum albumin indicated insufficient plasma volume replacement. This group had a significantly larger (p less than .05) amount of tissue water in skin, skeletal muscle, and jejunum than the other groups; no significant difference in lung or heart muscle water was found between the groups.(ABSTRACT TRUNCATED AT 250 WORDS) (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colloids: pharmacology, Dextrans: pharmacology, Hemodynamics: drug effects, Isotonic Solutions: pharmacology
in
Critical Care Medicine
volume
16
issue
4
pages
346 - 352
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:2450720
  • scopus:0023882635
ISSN
1530-0293
language
English
LU publication?
no
id
36c4555b-98fc-4fde-ab1c-bcecd41b0e5e (old id 3634409)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/2450720?dopt=Abstract
date added to LUP
2013-07-02 13:01:14
date last changed
2017-07-30 04:57:12
@article{36c4555b-98fc-4fde-ab1c-bcecd41b0e5e,
  abstract     = {Hemodynamic effects of iso-oncotic 3% dextran-60, 6% dextran-70, and Ringer's acetate were compared in 28 male pigs (25 to 30 kg) subjected to experimental trauma and hemorrhage. The animals were kept anesthetized with 75% N2O/25% O2, 0.8% halothane. Hemodynamic and respiratory conditions were allowed to stabilize for one hour preoperatively (baseline data). After surgical trauma (arthroplasty), three 0.5 L of arterial blood samples were withdrawn and replaced with autologous red cells mixed with one liter of 3% dextran-60 in one group 1 (n = 9), one liter of 6% dextran-70 in group 2 (n = 10), and 3 L of Ringer's acetate in group 3 (n = 9). Pulmonary capillary wedge pressure (WP) was kept at baseline level for a further 10 h with infusion of the respective fluid; for this purpose, groups 1 through 3 needed additional infusions of 0.8 +/- 0.3, 0.5 +/- 0.4, and 5.3 +/- 3 (SD) L, respectively. Group 1 showed the highest jejunal capillary blood flow at 10 h and the lowest intragroup variations in hemodynamic and respiratory data. Group 2 had the highest pulmonary arterial pressures and group 3 had the lowest colloid oncotic and arterial BP and left ventricular volume indices. In group 3, the Hct and serum albumin indicated insufficient plasma volume replacement. This group had a significantly larger (p less than .05) amount of tissue water in skin, skeletal muscle, and jejunum than the other groups; no significant difference in lung or heart muscle water was found between the groups.(ABSTRACT TRUNCATED AT 250 WORDS)},
  author       = {Schött, Ulf and Lindbom, L O and Sjöstrand, U},
  issn         = {1530-0293},
  keyword      = {Colloids: pharmacology,Dextrans: pharmacology,Hemodynamics: drug effects,Isotonic Solutions: pharmacology},
  language     = {eng},
  number       = {4},
  pages        = {346--352},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Critical Care Medicine},
  title        = {Hemodynamic effects of colloid concentration in experimental hemorrhage: a comparison of Ringer's acetate, 3% dextran-60, and 6% dextran-70.},
  volume       = {16},
  year         = {1988},
}