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Three per cent dextran-60 as a plasma substitute in blood component therapy. I. An alternative in surgical blood loss replacement.

Schött, Ulf LU ; Sjöstrand, U; Thorén, T and Berséus, O (1985) In Acta Anaesthesiologica Scandinavica 29(8). p.767-774
Abstract
Microaggregate-poor erythrocyte concentrate with 3% dextran-60 as a plasma substitute was compared with microaggregate-poor whole blood for replacement of intra-operative and immediately postoperative blood loss. Sixty patients undergoing total hip arthroplasty randomly received either of these two forms of therapy. In accordance with the clinical routine of our orthopedic department, an infusion of 500 ml of 6% dextran-70 (Macrodex) was given as thrombo-prophylaxis in both groups. Use of 3% dextran-60 as a plasma substitute in blood component therapy for surgical hemorrhage of up to 50% of the calculated blood volume caused no increase in bleeding tendency or frequency of postoperative hematoma compared with whole blood replacement.... (More)
Microaggregate-poor erythrocyte concentrate with 3% dextran-60 as a plasma substitute was compared with microaggregate-poor whole blood for replacement of intra-operative and immediately postoperative blood loss. Sixty patients undergoing total hip arthroplasty randomly received either of these two forms of therapy. In accordance with the clinical routine of our orthopedic department, an infusion of 500 ml of 6% dextran-70 (Macrodex) was given as thrombo-prophylaxis in both groups. Use of 3% dextran-60 as a plasma substitute in blood component therapy for surgical hemorrhage of up to 50% of the calculated blood volume caused no increase in bleeding tendency or frequency of postoperative hematoma compared with whole blood replacement. Plasma protein levels were low immediately postoperatively in patients given the dextran, but from the 4th postoperative day onward there was no difference between the groups. Applied in clinical practice, this would be efficient in saving plasma for other urgent purposes. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
Plasma Substitutes: therapeutic use, Hemorrhage: therapy, Blood Proteins: analysis, Dextrans: therapeutic use, Surgical Procedures, Operative: adverse effects
in
Acta Anaesthesiologica Scandinavica
volume
29
issue
8
pages
767 - 774
publisher
Wiley-Blackwell
external identifiers
  • pmid:2417434
  • scopus:0022399904
ISSN
0001-5172
language
English
LU publication?
yes
id
8af2a0f2-b8e2-487d-9bf0-1271f93983c2 (old id 3634435)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/2417434?dopt=Abstract
date added to LUP
2013-07-02 13:03:22
date last changed
2017-08-06 04:46:25
@article{8af2a0f2-b8e2-487d-9bf0-1271f93983c2,
  abstract     = {Microaggregate-poor erythrocyte concentrate with 3% dextran-60 as a plasma substitute was compared with microaggregate-poor whole blood for replacement of intra-operative and immediately postoperative blood loss. Sixty patients undergoing total hip arthroplasty randomly received either of these two forms of therapy. In accordance with the clinical routine of our orthopedic department, an infusion of 500 ml of 6% dextran-70 (Macrodex) was given as thrombo-prophylaxis in both groups. Use of 3% dextran-60 as a plasma substitute in blood component therapy for surgical hemorrhage of up to 50% of the calculated blood volume caused no increase in bleeding tendency or frequency of postoperative hematoma compared with whole blood replacement. Plasma protein levels were low immediately postoperatively in patients given the dextran, but from the 4th postoperative day onward there was no difference between the groups. Applied in clinical practice, this would be efficient in saving plasma for other urgent purposes.},
  author       = {Schött, Ulf and Sjöstrand, U and Thorén, T and Berséus, O},
  issn         = {0001-5172},
  keyword      = {Plasma Substitutes: therapeutic use,Hemorrhage: therapy,Blood Proteins: analysis,Dextrans: therapeutic use,Surgical Procedures,Operative: adverse effects},
  language     = {eng},
  number       = {8},
  pages        = {767--774},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Three per cent dextran-60 as a plasma substitute in blood component therapy. I. An alternative in surgical blood loss replacement.},
  volume       = {29},
  year         = {1985},
}