Blood substitution and complement activation.
(1987) In Acta Anaesthesiologica Scandinavica 31(7). p.559-566- Abstract
- Complement activation was studied in 45 patients undergoing total hip arthroplasty under epidural anesthesia. The patients were randomly allocated to three groups. In Group I blood loss was replaced with microaggregate-poor erythrocyte concentrate (SAGM-ERC) plus 3% dextran-60 as plasma substitute, and postoperative analgesia was maintained with intramuscular ketobemidone. In Group II blood loss was replaced as in Group I, but epidural anesthesia was prolonged 12 h postoperatively and kept at a level of T4 with 0.5% bupivacaine. In Group III blood loss was replaced with non-frozen stored plasma plus SAGM-ERC, and postoperative analgesia was maintained with ketobemidone as in Group I. All groups received pre- and postoperative... (More)
- Complement activation was studied in 45 patients undergoing total hip arthroplasty under epidural anesthesia. The patients were randomly allocated to three groups. In Group I blood loss was replaced with microaggregate-poor erythrocyte concentrate (SAGM-ERC) plus 3% dextran-60 as plasma substitute, and postoperative analgesia was maintained with intramuscular ketobemidone. In Group II blood loss was replaced as in Group I, but epidural anesthesia was prolonged 12 h postoperatively and kept at a level of T4 with 0.5% bupivacaine. In Group III blood loss was replaced with non-frozen stored plasma plus SAGM-ERC, and postoperative analgesia was maintained with ketobemidone as in Group I. All groups received pre- and postoperative thrombo-prophylaxis with dextran. The plasma concentration of C3a-des-arginine (C3a-desArg) was measured by radioimmunoassay preoperatively, immediately after operation and 3, 6 and 18 h postoperatively. No significant differences in plasma C3 and C4 were found between the groups. C3a-desArg was significantly (P less than 0.01) increased up to 6 h postoperatively in Group III compared with both the preoperative value and Groups I and II. It is demonstrated that infusion of plasma can enhance or initiate endogenous complement activation. Blood component therapy with SAGM-ERC and 3% dextran-60, on the other hand, did not significantly increase the plasma level of C3a-desArg irrespective of the type of postoperative analgesia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3634441
- author
- Schött, Ulf LU ; Berséus, O and Järemo, P
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Blood Pressure: drug effects, Blood Substitutes: blood, Blood Substitutes: pharmacology, Complement Activation: drug effects, Hemodynamics: drug effects
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 31
- issue
- 7
- pages
- 559 - 566
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:3687352
- scopus:0023547145
- ISSN
- 0001-5172
- project
- Koagulation vid kirurgi och kritisk sjukdom
- language
- English
- LU publication?
- no
- id
- f23cdbe5-c459-4135-8a0e-eac919072a8d (old id 3634441)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/3687352?dopt=Abstract
- date added to LUP
- 2016-04-04 08:18:31
- date last changed
- 2021-01-03 05:42:05
@article{f23cdbe5-c459-4135-8a0e-eac919072a8d,
abstract = {{Complement activation was studied in 45 patients undergoing total hip arthroplasty under epidural anesthesia. The patients were randomly allocated to three groups. In Group I blood loss was replaced with microaggregate-poor erythrocyte concentrate (SAGM-ERC) plus 3% dextran-60 as plasma substitute, and postoperative analgesia was maintained with intramuscular ketobemidone. In Group II blood loss was replaced as in Group I, but epidural anesthesia was prolonged 12 h postoperatively and kept at a level of T4 with 0.5% bupivacaine. In Group III blood loss was replaced with non-frozen stored plasma plus SAGM-ERC, and postoperative analgesia was maintained with ketobemidone as in Group I. All groups received pre- and postoperative thrombo-prophylaxis with dextran. The plasma concentration of C3a-des-arginine (C3a-desArg) was measured by radioimmunoassay preoperatively, immediately after operation and 3, 6 and 18 h postoperatively. No significant differences in plasma C3 and C4 were found between the groups. C3a-desArg was significantly (P less than 0.01) increased up to 6 h postoperatively in Group III compared with both the preoperative value and Groups I and II. It is demonstrated that infusion of plasma can enhance or initiate endogenous complement activation. Blood component therapy with SAGM-ERC and 3% dextran-60, on the other hand, did not significantly increase the plasma level of C3a-desArg irrespective of the type of postoperative analgesia.}},
author = {{Schött, Ulf and Berséus, O and Järemo, P}},
issn = {{0001-5172}},
keywords = {{Blood Pressure: drug effects; Blood Substitutes: blood; Blood Substitutes: pharmacology; Complement Activation: drug effects; Hemodynamics: drug effects}},
language = {{eng}},
number = {{7}},
pages = {{559--566}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Anaesthesiologica Scandinavica}},
title = {{Blood substitution and complement activation.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/3687352?dopt=Abstract}},
volume = {{31}},
year = {{1987}},
}