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Blood substitution and complement activation.

Schött, Ulf LU ; Berséus, O and Järemo, P (1987) In Acta Anaesthesiologica Scandinavica 31(7). p.559-566
Abstract
Complement activation was studied in 45 patients undergoing total hip arthroplasty under epidural anesthesia. The patients were randomly allocated to three groups. In Group I blood loss was replaced with microaggregate-poor erythrocyte concentrate (SAGM-ERC) plus 3% dextran-60 as plasma substitute, and postoperative analgesia was maintained with intramuscular ketobemidone. In Group II blood loss was replaced as in Group I, but epidural anesthesia was prolonged 12 h postoperatively and kept at a level of T4 with 0.5% bupivacaine. In Group III blood loss was replaced with non-frozen stored plasma plus SAGM-ERC, and postoperative analgesia was maintained with ketobemidone as in Group I. All groups received pre- and postoperative... (More)
Complement activation was studied in 45 patients undergoing total hip arthroplasty under epidural anesthesia. The patients were randomly allocated to three groups. In Group I blood loss was replaced with microaggregate-poor erythrocyte concentrate (SAGM-ERC) plus 3% dextran-60 as plasma substitute, and postoperative analgesia was maintained with intramuscular ketobemidone. In Group II blood loss was replaced as in Group I, but epidural anesthesia was prolonged 12 h postoperatively and kept at a level of T4 with 0.5% bupivacaine. In Group III blood loss was replaced with non-frozen stored plasma plus SAGM-ERC, and postoperative analgesia was maintained with ketobemidone as in Group I. All groups received pre- and postoperative thrombo-prophylaxis with dextran. The plasma concentration of C3a-des-arginine (C3a-desArg) was measured by radioimmunoassay preoperatively, immediately after operation and 3, 6 and 18 h postoperatively. No significant differences in plasma C3 and C4 were found between the groups. C3a-desArg was significantly (P less than 0.01) increased up to 6 h postoperatively in Group III compared with both the preoperative value and Groups I and II. It is demonstrated that infusion of plasma can enhance or initiate endogenous complement activation. Blood component therapy with SAGM-ERC and 3% dextran-60, on the other hand, did not significantly increase the plasma level of C3a-desArg irrespective of the type of postoperative analgesia. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
Blood Pressure: drug effects, Blood Substitutes: blood, Blood Substitutes: pharmacology, Complement Activation: drug effects, Hemodynamics: drug effects
in
Acta Anaesthesiologica Scandinavica
volume
31
issue
7
pages
559 - 566
publisher
Wiley-Blackwell
external identifiers
  • pmid:3687352
  • scopus:0023547145
ISSN
0001-5172
language
English
LU publication?
yes
id
f23cdbe5-c459-4135-8a0e-eac919072a8d (old id 3634441)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/3687352?dopt=Abstract
date added to LUP
2013-06-26 15:32:48
date last changed
2017-07-30 04:50:04
@article{f23cdbe5-c459-4135-8a0e-eac919072a8d,
  abstract     = {Complement activation was studied in 45 patients undergoing total hip arthroplasty under epidural anesthesia. The patients were randomly allocated to three groups. In Group I blood loss was replaced with microaggregate-poor erythrocyte concentrate (SAGM-ERC) plus 3% dextran-60 as plasma substitute, and postoperative analgesia was maintained with intramuscular ketobemidone. In Group II blood loss was replaced as in Group I, but epidural anesthesia was prolonged 12 h postoperatively and kept at a level of T4 with 0.5% bupivacaine. In Group III blood loss was replaced with non-frozen stored plasma plus SAGM-ERC, and postoperative analgesia was maintained with ketobemidone as in Group I. All groups received pre- and postoperative thrombo-prophylaxis with dextran. The plasma concentration of C3a-des-arginine (C3a-desArg) was measured by radioimmunoassay preoperatively, immediately after operation and 3, 6 and 18 h postoperatively. No significant differences in plasma C3 and C4 were found between the groups. C3a-desArg was significantly (P less than 0.01) increased up to 6 h postoperatively in Group III compared with both the preoperative value and Groups I and II. It is demonstrated that infusion of plasma can enhance or initiate endogenous complement activation. Blood component therapy with SAGM-ERC and 3% dextran-60, on the other hand, did not significantly increase the plasma level of C3a-desArg irrespective of the type of postoperative analgesia.},
  author       = {Schött, Ulf and Berséus, O and Järemo, P},
  issn         = {0001-5172},
  keyword      = {Blood Pressure: drug effects,Blood Substitutes: blood,Blood Substitutes: pharmacology,Complement Activation: drug effects,Hemodynamics: drug effects},
  language     = {eng},
  number       = {7},
  pages        = {559--566},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Blood substitution and complement activation.},
  volume       = {31},
  year         = {1987},
}