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Systematic classification of primary immunodeficiencies based on clinical, pathological, and laboratory parameters.

Samarghitean, Crina; Ortutay, Csaba and Vihinen, Mauno LU (2009) In Journal of immunology (Baltimore, Md. : 1950) 183(11). p.7569-7575
Abstract
The classification of diseases has several important applications ranging from diagnosis and choice of treatment to demographics. To date, classifications have been successfully created manually, often within international consortia. Some groups of diseases, such as primary immunodeficiencies (PIDs), are especially hard to nosologically cluster due, on one hand, to the presence of a wide variety of disorders and, in contrast, because of overlapping characteristics. More than 200 PIDs affecting components of the innate and adaptive immune systems have been described. Clinical, pathological, and laboratory characteristics were collected and used to group PIDs. A consensus of at least five independent methods provided a novel classification... (More)
The classification of diseases has several important applications ranging from diagnosis and choice of treatment to demographics. To date, classifications have been successfully created manually, often within international consortia. Some groups of diseases, such as primary immunodeficiencies (PIDs), are especially hard to nosologically cluster due, on one hand, to the presence of a wide variety of disorders and, in contrast, because of overlapping characteristics. More than 200 PIDs affecting components of the innate and adaptive immune systems have been described. Clinical, pathological, and laboratory characteristics were collected and used to group PIDs. A consensus of at least five independent methods provided a novel classification of 11 groups, which revealed previously unknown features and relationships of PIDs. Comparison of the classification to independent features, including the severity and therapy of the diseases, functional classification of proteins, and network vulnerability, indicated a strong statistical support. The method can be applied to any group of diseases. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Classification: methods, Immunologic Deficiency Syndromes: classification
in
Journal of immunology (Baltimore, Md. : 1950)
volume
183
issue
11
pages
7569 - 7575
publisher
American Association of Immunologists
external identifiers
  • pmid:19917694
  • scopus:73349128119
ISSN
1550-6606
DOI
10.4049/jimmunol.0901837
language
English
LU publication?
no
id
a8b84217-c516-47ba-a49c-01360f6f5d20 (old id 3634773)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19917694?dopt=Abstract
date added to LUP
2013-06-12 20:39:46
date last changed
2017-01-22 04:20:57
@article{a8b84217-c516-47ba-a49c-01360f6f5d20,
  abstract     = {The classification of diseases has several important applications ranging from diagnosis and choice of treatment to demographics. To date, classifications have been successfully created manually, often within international consortia. Some groups of diseases, such as primary immunodeficiencies (PIDs), are especially hard to nosologically cluster due, on one hand, to the presence of a wide variety of disorders and, in contrast, because of overlapping characteristics. More than 200 PIDs affecting components of the innate and adaptive immune systems have been described. Clinical, pathological, and laboratory characteristics were collected and used to group PIDs. A consensus of at least five independent methods provided a novel classification of 11 groups, which revealed previously unknown features and relationships of PIDs. Comparison of the classification to independent features, including the severity and therapy of the diseases, functional classification of proteins, and network vulnerability, indicated a strong statistical support. The method can be applied to any group of diseases.},
  author       = {Samarghitean, Crina and Ortutay, Csaba and Vihinen, Mauno},
  issn         = {1550-6606},
  keyword      = {Classification: methods,Immunologic Deficiency Syndromes: classification},
  language     = {eng},
  number       = {11},
  pages        = {7569--7575},
  publisher    = {American Association of Immunologists},
  series       = {Journal of immunology (Baltimore, Md. : 1950)},
  title        = {Systematic classification of primary immunodeficiencies based on clinical, pathological, and laboratory parameters.},
  url          = {http://dx.doi.org/10.4049/jimmunol.0901837},
  volume       = {183},
  year         = {2009},
}